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Study · Animal study (in vivo) · rat · 1991

3 results

Oxytocin but not vasopressin facilitates social recognition following injection into the medial preoptic area of the rat brain.

Popik P, van Ree JM

European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology1 Dec 1991Cited by 82 (Europe PMC)

PMID1668316 (opens in a new tab)DOI10.1016/0924-977x(91)90010-r (opens in a new tab)PepBankPUB-01668316
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In adult male rats, oxytocin injected into the medial preoptic area at 0.3-1000 pg facilitated social recognition of juveniles.

    In plain wordsIn rats, oxytocin injected into a brain area called the medial preoptic area helped them recognise other young rats.

    Peptide
    Oxytocin
    Outcome
    IncreaseSocial recognition, medial preoptic area injection
    Study

    ratn: not reported in source

    Outcome group
    Cognition and memory · Nervous system and cognition
    Studied dose
    0.3-1000 pg · injection into the medial preoptic areaAs given in this study (rat).

    Source sentences

    Summary
    It was found that oxytocin given in a wide range of doses (0.3-1000 pg) facilitated social recognition.
    2 context sentences
    Summary · context
    Social recognition of juvenile rats by adult male residents has been shown to be modulated by peripheral administration of neurohypophyseal hormones vasopressin and oxytocin.
    Summary · context
    In the present study, the effects of these peptides on social recognition were investigated after local injection into the medial preoptic area of the hypothalamus.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In rats, oxytocin injected into the septum at 0.03-3 pg was not effective on social recognition.

    In plain wordsIn rats, oxytocin injected into the septum did not help social recognition.

    Peptide
    Oxytocin
    Outcome
    No significant changeSocial recognition, septum injection
    Study

    ratn: not reported in source

    Outcome group
    Cognition and memory · Nervous system and cognition
    Studied dose
    0.03-3 pg · injection into the septumAs given in this study (rat).

    Source sentences

    Summary
    Oxytocin injected into the septum in doses of 0.03-3 pg was not effective.
    1 context sentence
    Summary · context
    In the present study, the effects of these peptides on social recognition were investigated after local injection into the medial preoptic area of the hypothalamus.

Studies that did not test the peptide alone1

In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Oxytocin.

  1. 03AnimalNot a test of Oxytocin aloneAnimal study (in vivo)Mechanism

    In rats, the facilitation of social recognition by oxytocin in the medial preoptic area was not blocked by pretreatment with an oxytocin receptor antagonist.

    In plain wordsIn rats, the oxytocin boost to social recognition was not stopped by a drug that blocks the oxytocin receptor.

    Peptide
    Oxytocin
    Outcome
    No significant changeOxytocin receptor antagonist pretreatment on social recognition effect
    Study

    ratn: not reported in source

    Outcome group
    Cognition and memory · Nervous system and cognition

    Source sentences

    Summary
    This effect was not blocked by pretreatment with oxytocin receptor antagonist desGly(NH2)9-d(CH2)5[Tyr(Me)2Thr4]OVT.
    1 context sentence
    Summary · context
    In the present study, the effects of these peptides on social recognition were investigated after local injection into the medial preoptic area of the hypothalamus.

    In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 20:03 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:51 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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