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Study · Not a test of the peptide alone · 1991

4 results

Evidence for a role of protein kinase-C in His-D-Trp-Ala-Trp-D-Phe-Lys-NH2-induced growth hormone release from rat primary pituitary cells.

Cheng K, Chan WW, Butler B, Barreto A Jr, Smith RG

Endocrinology1 Dec 1991Cited by 78 (Europe PMC)

PMID1659529 (opens in a new tab)DOI10.1210/endo-129-6-3337 (opens in a new tab)PepBankPUB-01659529
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone4

In this study, GHRP-6 was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking GHRP-6.

  1. 01LabNot a test of GHRP-6 aloneIn vitro (cells)Mechanism

    In rat pituitary cells, phloretin markedly inhibited GHRP‑6-stimulated GH release.

    In plain wordsIn cells from rats, phloretin reduced GH release stimulated by GHRP‑6.

    Peptide
    GHRP-6
    Outcome
    DecreasePhloretin inhibition of GH response
    Study

    ratn: not reported in source

    primary pituitary cells
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones

    Source sentences

    Summary
    Phloretin, a protein kinase-C inhibitor, in a concentration range of 10-250 microM had very little or no effect on basal and GRF-stimulated GH release, but markedly inhibited the stimulatory effects induced by either PMA or GHRP-6.

    In this study, GHRP-6 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHRP-6.

  2. 02LabNot a test of GHRP-6 aloneIn vitro (cells)Mechanism

    In rat pituitary cells, protein kinase-C depletion attenuated the GH response to GHRP‑6.

    In plain wordsIn cells from rats, protein kinase-C depletion reduced the GH response to GHRP‑6.

    Peptide
    GHRP-6
    Outcome
    DecreaseGH response after kinase depletion
    Study

    ratn: not reported in source

    primary pituitary cells
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones

    Source sentences

    Summary
    The protein kinase-C-depleted cells had an attenuated GHRP-6 response, but they responded normally to GRF.
    1 context sentence
    Summary · context
    Incubation of rat pituitary cells with 10(-6) M PMA for 24 h completely down-regulated protein kinase-C, since such PMA-pretreated cells did not release GH in response to a second dose of PMA.

    In this study, GHRP-6 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHRP-6.

  3. 03LabNot a test of GHRP-6 aloneIn vitro (cells)Mechanism

    In rat pituitary cells, protein kinase-C down-regulation inhibited synergistic GH release with GHRP‑6 and GRF.

    In plain wordsIn cells from rats, protein kinase-C reduction inhibited GH release stimulated by GHRP‑6 with GRF.

    Peptide
    GHRP-6
    Outcome
    DecreaseCombined GH response after kinase depletion
    Study

    ratn: not reported in source

    primary pituitary cells
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones

    Source sentences

    Summary
    Moreover, the synergistic effects of GHRP-6 and GRF on GH release and cAMP accumulation were also greatly inhibited by protein kinase-C down-regulation.

    In this study, GHRP-6 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHRP-6.

  4. 04LabNot a test of GHRP-6 aloneIn vitro (cells)Mechanism

    In rat pituitary cells, protein kinase-C down-regulation inhibited synergistic cAMP accumulation with GHRP‑6 and GRF.

    In plain wordsIn cells from rats, protein kinase-C reduction inhibited cAMP accumulation stimulated by GHRP‑6 with GRF.

    Peptide
    GHRP-6
    Outcome
    DecreaseCombined cAMP response after kinase depletion
    Study

    ratn: not reported in source

    primary pituitary cells
    Outcome group
    Receptor activity and mechanism · Endocrine and hormones

    Source sentences

    Summary
    Moreover, the synergistic effects of GHRP-6 and GRF on GH release and cAMP accumulation were also greatly inhibited by protein kinase-C down-regulation.

    In this study, GHRP-6 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHRP-6.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:59 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:13 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

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