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Study · Animal study (in vivo) · mouse · 1991

4 results

Thymic atrophy in type 2 reovirus infected mice: immunosuppression and effects of thymic hormone. Thymic atrophy caused by reo-2.

Onodera T, Taniguchi T, Tsuda T, Yoshihara K, Shimizu S, Sato M, Awaya A, Hayashi T

Thymus1 Sept 1991Cited by 16 (Europe PMC)

PMID1656552 (opens in a new tab)PepBankPUB-01656552
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In reovirus-infected mice, FTS enhanced antibody production against SRBC more efficiently than MDP.

    In plain wordsIn reovirus-infected mice, FTS improved antibody production against SRBC more efficiently than MDP.

    Peptide
    Thymulin (serum thymic factor)
    Outcome
    IncreaseAntibody production against SRBC
    Study

    mousen: not reported in source

    Suckling mice infected with reovirus type 2
    Comparator
    MDP
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Thymic hormones such as FTS and TP5 enhanced antibody production to SRBC and LPS more efficiently than MDP.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In reovirus-infected mice, FTS enhanced antibody production against LPS more efficiently than MDP.

    In plain wordsIn reovirus-infected mice, FTS improved antibody production against LPS more efficiently than MDP.

    Peptide
    Thymulin (serum thymic factor)
    Outcome
    IncreaseAntibody production against LPS
    Study

    mousen: not reported in source

    Suckling mice infected with reovirus type 2
    Comparator
    MDP
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Thymic hormones such as FTS and TP5 enhanced antibody production to SRBC and LPS more efficiently than MDP.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In reovirus-infected mice treated with FTS, the percentage of CD4-positive single-positive cells increased slightly.

    In plain wordsIn reovirus-infected mice, FTS slightly increased the percentage of CD4-positive single-positive cells.

    Peptide
    Thymulin (serum thymic factor)
    Outcome
    IncreaseCD4-positive single-positive thymocyte percentage
    Study

    mousen: not reported in source

    Suckling mice infected with reovirus type 2
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Flow cytometric analysis showed that percentage of CD4+ single positive cells was slightly increased in virus-infected mice treated with FTS, while there was no difference in the phenotypic distributions of thymocyte subpopulations among virus-infected mice, FTS-untreated and FTS-treated normal mice.

Studies that did not test the peptide alone1

In this study, Thymulin (serum thymic factor) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Thymulin (serum thymic factor).

  1. 04AnimalNot a test of Thymulin (serum thymic factor) aloneAnimal study (in vivo)Efficacy outcome

    Thymocyte subpopulation distributions did not differ among infected mice and normal mice with or without FTS treatment.

    In plain wordsIn mice, thymocyte subpopulation distributions were similar among infected animals and normal animals with or without FTS.

    Peptide
    Thymulin (serum thymic factor)
    Outcome
    No significant changeThymocyte subpopulation distributions
    Study

    mousen: not reported in source

    Suckling mice infected with reovirus type 2
    Outcome group
    Immune response · Immune and inflammation

    Source sentences

    Summary
    Flow cytometric analysis showed that percentage of CD4+ single positive cells was slightly increased in virus-infected mice treated with FTS, while there was no difference in the phenotypic distributions of thymocyte subpopulations among virus-infected mice, FTS-untreated and FTS-treated normal mice.

    In this study, Thymulin (serum thymic factor) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymulin (serum thymic factor).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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