Effects of ovine conceptus secretory proteins and progesterone on oxytocin-stimulated endometrial production of prostaglandin and turnover of inositol phosphate in ovariectomized ewes.

Ott TL, Mirando MA, Davis MA, Bazer FW

Journal of reproduction and fertility1 May 1992Cited by 22 (Europe PMC)

PMID1625235DOI10.1530/jrf.0.0950019PepBankPUB-01625235

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

1 result from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Mechanism
In ovariectomized ewes, those that responded to intravenous oxytocin with increased PGFM also showed increased oxytocin-stimulated inositol phosphate turnover on day 15.
In plain wordsIn ewes, animals that made more prostaglandin metabolite after oxytocin also showed a stronger oxytocin-driven signal in the womb lining.
Peptide
Oxytocin
Outcome
Not applicableOxytocin-induced PGFM response and inositol phosphate turnover
Study
sheepn: not reported in source
Ovariectomized ewes
Outcome group
Receptor activity and mechanism · Reproductive and sexual health
Studied dose
20 iu · intravenousAs given in this study (sheep).
Source sentences
Summary
Ewes that responded to oxytocin with increased PGFM exhibited increased oxytocin-stimulated turnover of inositol phosphate on day 15.
2 context sentences(design, population, supporting numbers)
Summary · context
Oxytocin-induced prostaglandin F2 alpha was measured as 13,14-dihydro-15-keto-prostaglandin F2 alpha (PGFM) on days 11, 12, 13 and 14 in plasma from three integrated, 10 min (10 ml) blood samples (0-10, 10-20, 20-30 min) obtained after intravenous injection of 20 iu oxytocin, and in a pre-oxytocin (…
Summary · context
Twelve ewes were ovariectomized on day 4 of the cycle (oestrus = day 0) and assigned in a 2 x 2 factorial arrangement, to receive either 1.5 mg ovine serum proteins (SP) or oCSP containing 25 micrograms ovine trophoblast protein 1 (oTP-1) (by radioimmunoassay) in 1.5 mg total protein into each uteri…
Report a problemFND-0162523503

Studies that did not test the peptide alone2

In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Oxytocin.

02AnimalNot a test of Oxytocin aloneAnimal study (in vivo)Mechanism
In ovariectomized ewes, ovine conceptus secretory proteins abolished oxytocin-induced endometrial prostaglandin secretion only when progesterone was maintained to day 15.
In plain wordsIn ewes, proteins from the early embryo blocked the womb lining's prostaglandin response to oxytocin, but only when progesterone stayed high.
Peptide
Oxytocin
Outcome
DecreaseOxytocin-induced endometrial prostaglandin secretion with oCSP
Study
sheepn = 12
Ovariectomized ewes
Comparator
Ovine serum proteins
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Source sentences
Summary
Treatment with oCSP abolished oxytocin-induced endometrial secretion of prostaglandin only if progesterone was maintained to day 15 (P less than 0.01)
1 context sentence(design, population, supporting numbers)
Summary · context
Twelve ewes were ovariectomized on day 4 of the cycle (oestrus = day 0) and assigned in a 2 x 2 factorial arrangement, to receive either 1.5 mg ovine serum proteins (SP) or oCSP containing 25 micrograms ovine trophoblast protein 1 (oTP-1) (by radioimmunoassay) in 1.5 mg total protein into each uteri…
In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.
Report a problemFND-0162523501
03AnimalNot a test of Oxytocin aloneAnimal study (in vivo)Mechanism
In ovariectomized ewes, oCSP inhibited oxytocin-induced endometrial turnover of inositol phosphate, whereas serum proteins did not.
In plain wordsIn ewes, embryo proteins reduced the womb lining's response to oxytocin, while ordinary serum proteins did not.
Peptide
Oxytocin
Outcome
DecreaseOxytocin-induced endometrial inositol phosphate turnover with oCSP
Study
sheepn = 12
Ovariectomized ewes
Comparator
Ovine serum proteins
Outcome group
Receptor activity and mechanism · Reproductive and sexual health
Source sentences
Summary
in ewes receiving such treatment, oCSP inhibited (P less than 0.01), but SP did not inhibit, oxytocin-induced endometrial turnover of inositol phosphate (P less than 0.06)
1 context sentence(design, population, supporting numbers)
Summary · context
Twelve ewes were ovariectomized on day 4 of the cycle (oestrus = day 0) and assigned in a 2 x 2 factorial arrangement, to receive either 1.5 mg ovine serum proteins (SP) or oCSP containing 25 micrograms ovine trophoblast protein 1 (oTP-1) (by radioimmunoassay) in 1.5 mg total protein into each uteri…
In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.
Report a problemFND-0162523502

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
11 Oct 2026, 20:03 UTC
Study results updated
Version 1
9 Oct 2026, 02:52 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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MeSH terms

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