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Study · Non-randomized trial · n = 17 · 1992

2 results

Six-year results of a randomized, prospective trial of human growth hormone and oxandrolone in Turner syndrome.

Rosenfeld RG, Frane J, Attie KM, Brasel JA, Burstein S, Cara JF, Chernausek S, Gotlin RW, Kuntze J, Lippe BM

The Journal of pediatrics1 Jul 1992Cited by 86 (Europe PMC)

PMID1625092 (opens in a new tab)DOI10.1016/s0022-3476(05)82540-5 (opens in a new tab)PepBankPUB-01625092
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: CC BY-NC-ND. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. 2 results from people.

  1. 01HumanNon-randomized trialEfficacy outcome

    In girls with Turner syndrome receiving hGH alone, 14 of 17 girls exceeded expected adult height.

    In plain wordsIn girls with Turner syndrome receiving hGH alone, 14 of 17 exceeded expected adult height.

    Peptide
    HGH (somatotropin)
    Outcome
    Not applicableExceeding expected adult height with hGH alone
    Study

    n = 17

    Comparator
    Expected adult height
    Outcome group
    Linear growth · Endocrine and hormones
    Studied dose
    Dose not stated · 3 to 6 yearsAs given in this study (human).

    Measurements

    Exceeding expected height
    82%
    hGH alone
    Exceeding expected height
    14 girls
    hGH alone

    Source sentences

    Summary
    Treatment is continuing in over half of the subjects; at present, 14 (82%) of 17 girls receiving hGH alone and 41 (91%) of 45 girls receiving combination therapy exceeded their expected adult heights.
    2 context sentences
    Summary · context
    Seventy girls with Turner syndrome, verified by karyotype, were randomly assigned to observation or treatment with human growth hormone (hGH), oxandrolone, or a combination of hGH plus oxandrolone for a period of 12 to 24 months, to assess the effect of treatment on growth velocity and adult height.
    Summary · context
    Subsequently, all subjects received either hGH alone or hGH plus oxandrolone.
  2. 02HumanNon-randomized trialEfficacy outcome

    In girls with Turner syndrome, hGH alone sustained increased growth rate for at least 6 years compared with anticipated untreated growth.

    In plain wordsIn girls with Turner syndrome, hGH alone increased growth rate compared with anticipated untreated growth for at least 6 years.

    Peptide
    HGH (somatotropin)
    Outcome
    IncreaseGrowth rate with hGH alone
    Study

    n: not reported in source

    Comparator
    Anticipated untreated growth rate
    Outcome group
    Linear growth · Endocrine and hormones
    Studied dose
    Dose not stated · 3 to 6 yearsAs given in this study (human).

    Source sentences

    Summary
    When compared with the anticipated growth rate in untreated patients, the growth rate after treatment with hGH, both alone and in combination with oxandrolone, showed a sustained increase for at least 6 years.
    2 context sentences
    Summary · context
    Seventy girls with Turner syndrome, verified by karyotype, were randomly assigned to observation or treatment with human growth hormone (hGH), oxandrolone, or a combination of hGH plus oxandrolone for a period of 12 to 24 months, to assess the effect of treatment on growth velocity and adult height.
    Summary · context
    Subsequently, all subjects received either hGH alone or hGH plus oxandrolone.

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    28 Oct 2026, 02:03 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:37 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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