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Study · Animal study (in vivo) · rat · 1992

1 result

Effects of thyrotropin-releasing hormone, oxytocin, and prolactin on thiopenthal-induced narcosis in rats.

Drago F, Mauceri F, Fidilio M, Cavaliere S, Pulvirenti L, Foti F

Brain research bulletin1 May 1992Cited by 2 (Europe PMC)

PMID1617461 (opens in a new tab)DOI10.1016/0361-9230(92)90260-5 (opens in a new tab)PepBankPUB-01617461
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study1

1 result from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In male rats, intravenous oxytocin at 200, 300 and 400 micrograms/kg was effective against thiopental-induced narcosis, as it reduced sleeping time.

    In plain wordsIn rats, oxytocin given into a vein shortened sleep time caused by an anaesthetic drug.

    Peptide
    Oxytocin
    Outcome
    DecreaseThiopental-induced sleeping time
    Study

    ratn: not reported in source

    Outcome group
    Sleep · Sleep
    Studied dose
    200, 300 and 400 micrograms/kg · intravenousAs given in this study (rat).

    Source sentences

    Summary
    Oxytocin was effective at all doses tested (200, 300, and 400 micrograms/kg).
    2 context sentences
    Summary · context
    These results indicate that various neuropeptides are capable of reducing the duration of thiopenthal-induced sleep in rats.
    Summary · context
    Neuropeptides that may induce behavioral activation--thyrotropin-releasing hormone (TRH), oxytocin (OXY), and prolactin (PRL)--were tested on thiopenthal-induced narcosis after IV administration in male rats.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 20:03 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:52 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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