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Study · Animal study (in vivo) · rat · 1992

3 results

Vasoactive intestinal peptide inhibits the steroid-induced LH surge in the ovariectomized rat.

Weick RF, Stobie KM

The Journal of endocrinology1 Jun 1992Cited by 23 (Europe PMC)

PMID1613444 (opens in a new tab)DOI10.1677/joe.0.1330433 (opens in a new tab)PepBankPUB-01613444
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In ovariectomized rats, vasoactive intestinal peptide infused into the third ventricle suppressed the steroid-induced LH rise at 16.00 and 18.00 h, whereas saline-infused rats showed a normal LH surge.

    In plain wordsIn rats, VIP infused into the brain kept LH from rising significantly at first, compared with saline.

    Peptide
    Vasoactive intestinal peptide (VIP, aviptadil)
    Outcome
    DecreasePlasma LH at 16.00 and 18.00 h
    Study

    ratn: not reported in source

    Ovariectomized rats with steroid-induced LH surge
    Comparator
    Saline infusion
    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    Dose not stated · third cerebral ventricle infusion · 3 hoursAs given in this study (rat).

    Source sentences

    Summary
    Plasma LH in animals infused with VIP was not significantly higher than control levels at 16.00 or 18.00 h.
    2 context sentences
    Summary · context
    Saline-infused animals showed a normal LH surge, with mean plasma LH concentrations reaching a peak at 18.00 h, declining by 20.00 h and reaching control (12.00 h) levels by 22.00 h.
    Summary · context
    Vasoactive intestinal peptide (VIP) or saline was infused into the third cerebral ventricle from 13.30 to 16.30 h on the afternoon of the anticipated LH surge.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In ovariectomized rats, plasma LH in vasoactive intestinal peptide-infused animals had risen to the level of saline-infused rats by 20.00 h and returned to control levels by 22.00 h.

    In plain wordsIn rats, LH after VIP infusion caught up with the saline level by 20.00 h and later returned to baseline.

    Peptide
    Vasoactive intestinal peptide (VIP, aviptadil)
    Outcome
    No significant changePlasma LH at 20.00 and 22.00 h
    Study

    ratn: not reported in source

    Ovariectomized rats with steroid-induced LH surge
    Comparator
    Saline infusion
    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    Dose not stated · third cerebral ventricle infusion · 3 hoursAs given in this study (rat).

    Source sentences

    Summary
    By 20.00 h, mean LH levels in VIP-infused rats had risen to the levels seen at that time in saline-infused rats, and by 22.00 h LH had returned to control levels in VIP-infused animals.
    1 context sentence
    Summary · context
    Vasoactive intestinal peptide (VIP) or saline was infused into the third cerebral ventricle from 13.30 to 16.30 h on the afternoon of the anticipated LH surge.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In ovariectomized rats, vasoactive intestinal peptide infusion did not appear to affect the timing of the LH surge.

    In plain wordsIn rats, VIP infusion did not seem to change when the LH surge happened.

    Peptide
    Vasoactive intestinal peptide (VIP, aviptadil)
    Outcome
    No significant changeTiming of the LH surge
    Study

    ratn: not reported in source

    Ovariectomized rats with steroid-induced LH surge
    Comparator
    Saline infusion
    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    Dose not stated · third cerebral ventricle infusion · 3 hoursAs given in this study (rat).

    Source sentences

    Summary
    nor does VIP appear to affect the timing of the LH surge.
    1 context sentence
    Summary · context
    Vasoactive intestinal peptide (VIP) or saline was infused into the third cerebral ventricle from 13.30 to 16.30 h on the afternoon of the anticipated LH surge.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    12 Oct 2026, 12:58 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 12:41 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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