Fetal development of delta-sleep-inducing-peptide-like immunoreactivity in hypothalamus of guinea pig with special regard to the prenatal colocalization with gonadotropin-releasing-hormone-like immunoreactivity.

Pu LP, Dubois PM

Neuroendocrinology1 Jan 1992Cited by 1 (Europe PMC)

PMID1608510DOI10.1159/000126098PepBankPUB-01608510

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

No result from this study comes from a test of the peptide.

Natural levels measured4

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

01AnimalEndogenous levelAnimal study (in vivo)Other
In fetal guinea pig hypothalamus, DSIP immunoreactivity was first detected at the 38th day of gestation, 10 days after GnRH immunoreactivity first appeared at day 28.
In plain wordsIn guinea pig fetuses, natural DSIP-like material first appeared in the hypothalamus at day 38 of gestation, later than GnRH.
Peptide
Delta sleep-inducing peptide (DSIP)
Outcome
Not applicableOnset of DSIP immunoreactivity in fetal hypothalamus
Study
guinea pign: not reported in source
fetal hypothalamus sections
Outcome group
Endogenous peptide levels · Nervous system and cognition
Source sentences
Summary
Using indirect immunofluorescent and sequential double-immunolabeling (elution-restaining) techniques, the results indicated that DSIP immunoreactivity was initially detected at the 38th day of gestation. In contrast to the first appearance of GnRH immunoreactivity at day 28, therefore, a 10-day delay was found.
1 context sentence(design, population, supporting numbers)
Summary · context
To support the possibility that DSIP also participates in fetal neuroendocrine events and to demonstrate the ontogenic evidence of coexisting neuropeptides, we have performed a detailed immunocytochemical study of DSIP- and GnRH-immunoreactivity in fetal hypothalamus of guinea pig.
This result measures the body's own Delta sleep-inducing peptide (DSIP). Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-0160851001
02AnimalEndogenous levelAnimal study (in vivo)Mechanism
In fetal guinea pig hypothalamus, DSIP immunoreactivity was always labeled with GnRH from its first occurrence, whereas some GnRH-immunoreactive structures lacked DSIP immunoreactivity.
In plain wordsIn guinea pig fetuses, natural DSIP-like material always appeared together with GnRH, but some GnRH structures had no DSIP.
Peptide
Delta sleep-inducing peptide (DSIP)
Outcome
Not applicableColocalization of DSIP and GnRH immunoreactivity
Study
guinea pign: not reported in source
fetal hypothalamus sections
Outcome group
Endogenous peptide levels · Nervous system and cognition
Source sentences
Summary
From its first occurrence, DSIP immunoreactivity was always labeled with GnRH, whereas some of GnRH-immunoreactive structures did not display a DSIP immunoreactivity.
1 context sentence(design, population, supporting numbers)
Summary · context
To support the possibility that DSIP also participates in fetal neuroendocrine events and to demonstrate the ontogenic evidence of coexisting neuropeptides, we have performed a detailed immunocytochemical study of DSIP- and GnRH-immunoreactivity in fetal hypothalamus of guinea pig.
This result measures the body's own Delta sleep-inducing peptide (DSIP). Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-0160851002
03AnimalEndogenous levelAnimal study (in vivo)Mechanism
In guinea pig hypothalamus before and after birth, DSIP and GnRH immunoreactivity overlapped completely in various regions.
In plain wordsIn guinea pigs, natural DSIP-like material and GnRH overlapped completely in many hypothalamic regions around birth.
Peptide
Delta sleep-inducing peptide (DSIP)
Outcome
Not applicableDSIP and GnRH overlap late in fetal development
Study
guinea pign: not reported in source
fetal hypothalamus sections
Outcome group
Endogenous peptide levels · Nervous system and cognition
Source sentences
Summary
But with the growth of fetus, especially before and after birth, a complete overlap between DSIP and GnRH immunoreactivity was observed throughout various regions of hypothalamus.
1 context sentence(design, population, supporting numbers)
Summary · context
To support the possibility that DSIP also participates in fetal neuroendocrine events and to demonstrate the ontogenic evidence of coexisting neuropeptides, we have performed a detailed immunocytochemical study of DSIP- and GnRH-immunoreactivity in fetal hypothalamus of guinea pig.
This result measures the body's own Delta sleep-inducing peptide (DSIP). Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-0160851003
04AnimalEndogenous levelAnimal study (in vivo)Other
In fetal guinea pig hypothalamus, labeled neurons were first uni- or bipolar, then smooth and irregular subtypes appeared, and multipolar and irregularly labeled neurons increased later.
In plain wordsIn guinea pig fetuses, neurons with natural DSIP-like material became more varied in shape as the fetus grew.
Peptide
Delta sleep-inducing peptide (DSIP)
Outcome
Not applicableMorphological development of DSIP/GnRH-labeled neurons
Study
guinea pign: not reported in source
fetal hypothalamus sections
Outcome group
Endogenous peptide levels · Nervous system and cognition
Source sentences
Summary
Initially, labeled neurons were visualized as uni- or bipolar types. Thereafter, their smooth and irregular subtypes could be distinguished. During later fetal age, relatively mature features were evident such as the increase of multipolar and irregularly labeled neurons.
1 context sentence(design, population, supporting numbers)
Summary · context
To support the possibility that DSIP also participates in fetal neuroendocrine events and to demonstrate the ontogenic evidence of coexisting neuropeptides, we have performed a detailed immunocytochemical study of DSIP- and GnRH-immunoreactivity in fetal hypothalamus of guinea pig.
This result measures the body's own Delta sleep-inducing peptide (DSIP). Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-0160851004

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
10 Oct 2026, 09:43 UTC
Study results updated
Version 1
9 Oct 2026, 03:04 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

Journal Article

MeSH terms

PepBank is a research reference. Talk to a doctor before you use any peptide.