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Study · Animal study (in vivo) · mouse · 1992

3 results

Human growth hormone promotes engraftment of murine or human T cells in severe combined immunodeficient mice.

Murphy WJ, Durum SK, Longo DL

Proceedings of the National Academy of Sciences of the United States of America1 May 1992Cited by 57 (Europe PMC)

PMID1584780 (opens in a new tab)PMCIDPMC49106 (opens in a new tab)DOI10.1073/pnas.89.10.4481 (opens in a new tab)PepBankPUB-01584780
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In SCID mice receiving syngeneic thymocytes, rhGH significantly improved lymph-node T-cell engraftment.

    In plain wordsIn mice with immune deficiency receiving thymocytes, rhGH improved T-cell engraftment in lymph nodes.

    Peptide
    HGH (somatotropin)
    Outcome
    IncreaseSyngeneic T-cell engraftment
    Study

    mousen: not reported in source

    SCID mice
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    SCID mice receiving syngeneic thymocytes and treated with recombinant human GH (rhGH) had significantly better T-cell engraftment in their lymph nodes.
    1 context sentence
    Summary · context
    Growth hormone (GH) has previously been implicated in T-cell development, and here we test its efficacy in promoting T-lymphocyte engraftment in mice with severe combined immune deficiency (SCID).
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In SCID mice receiving human peripheral blood lymphocytes, rhGH strongly promoted human T-cell engraftment.

    In plain wordsIn mice with immune deficiency receiving human lymphocytes, rhGH promoted human T-cell engraftment.

    Peptide
    HGH (somatotropin)
    Outcome
    IncreaseHuman T-cell engraftment
    Study

    mousen: not reported in source

    SCID mice
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Human T-cell engraftment was also strongly promoted by rhGH in SCID recipients receiving human peripheral blood lymphocytes.
    1 context sentence
    Summary · context
    Growth hormone (GH) has previously been implicated in T-cell development, and here we test its efficacy in promoting T-lymphocyte engraftment in mice with severe combined immune deficiency (SCID).
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In SCID mice, human T cells were detected in the thymus after rhGH treatment.

    In plain wordsIn mice with immune deficiency, human T cells were detected in the thymus after rhGH treatment.

    Peptide
    HGH (somatotropin)
    Outcome
    Not applicableHuman T cells in thymus
    Study

    mousen: not reported in source

    SCID mice
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Additionally, although mature human cells have not been thought to enter the murine thymus, human T cells were detected in the SCID thymus after rhGH treatment.
    1 context sentence
    Summary · context
    Growth hormone (GH) has previously been implicated in T-cell development, and here we test its efficacy in promoting T-lymphocyte engraftment in mice with severe combined immune deficiency (SCID).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    28 Oct 2026, 02:03 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:36 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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