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Study · Ex vivo tissue · mouse · 1992

3 results

In vitro restoration by thymulin of NK activity of cells from old mice.

Muzzioli M, Mocchegiani E, Bressani N, Bevilacqua P, Fabris N

International journal of immunopharmacology1 Jan 1992Cited by 26 (Europe PMC)

PMID1582734 (opens in a new tab)DOI10.1016/0192-0561(92)90105-t (opens in a new tab)PepBankPUB-01582734
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabEx vivo tissueActivity measurement

    In spleen cells from old mice, zinc-bound thymulin restored basal NK cytotoxicity in vitro.

    In plain wordsIn lab tests, zinc-bound thymulin restored basal natural killer cell activity in spleen cells from old mice.

    Peptide
    Thymulin (serum thymic factor)
    Outcome
    IncreaseBasal NK cytotoxicity
    Study

    mousen: not reported in source

    Spleen cells from old mice
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    is able, when administered in vitro, to restore the crippled NK cytotoxicity of spleen cells from old mice.
    1 context sentence
    Summary · context
    The action is exerted on the basal NK activity and not on IFN-boosted NK cytotoxicity, at variance with the restoration obtained in similar experimental conditions with thyroid hormones, thus suggesting that different mechanisms or maturative steps of NK cells are involved.
  2. 02LabEx vivo tissueActivity measurement

    In spleen cells from old mice, zinc-unbound FTS did not restore NK cytotoxicity.

    In plain wordsIn lab tests, zinc-unbound FTS did not restore natural killer cell activity in spleen cells from old mice.

    Peptide
    Thymulin (serum thymic factor)
    Outcome
    No significant changeNK cytotoxicity with zinc-unbound FTS
    Study

    mousen: not reported in source

    Spleen cells from old mice
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Neither the zinc-unbound form of the hormone (FTS) nor zinc ions alone are effective.
  3. 03LabEx vivo tissueActivity measurement

    In spleen cells from old mice, thymulin did not affect IFN-boosted NK cytotoxicity.

    In plain wordsIn lab tests, thymulin did not affect interferon-boosted natural killer cell activity in spleen cells from old mice.

    Peptide
    Thymulin (serum thymic factor)
    Outcome
    No significant changeIFN-boosted NK cytotoxicity
    Study

    mousen: not reported in source

    Spleen cells from old mice
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The action is exerted on the basal NK activity and not on IFN-boosted NK cytotoxicity, at variance with the restoration obtained in similar experimental conditions with thyroid hormones, thus suggesting that different mechanisms or maturative steps of NK cells are involved.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 2

    21 Oct 2026, 13:55 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

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