Effects of short-term growth hormone therapy in rats undergoing 75% small intestinal resection.

Shulman DI, Hu CS, Duckett G, Lavallee-Grey M

Journal of pediatric gastroenterology and nutrition1 Jan 1992Cited by 75 (Europe PMC)

PMID1573509DOI10.1097/00005176-199201000-00002PepBankPUB-01573509

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study8

8 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In rats with intestinal resection, body weight did not differ between high-dose hGH and resection controls.
In plain wordsIn rats with intestinal resection, body weight did not differ between high-dose hGH and resection controls.
Peptide
HGH (somatotropin)
Outcome
No significant changeBody weight high dose
Study
ratn: not reported in source
75% small intestinal resection
Comparator
Resection control
Outcome group
Body weight · Metabolic and weight
Studied dose
1.0 mg/kg/dose every other day · subcutaneous · 28 daysAs given in this study (rat).
Source sentences
Summary
After 28 days, SG-control and SG-LDGH rats weighed significantly less than the sham control group; the mean weight of the SG-HDGH group was not different from other groups.
2 context sentences(design, population, supporting numbers)
Summary · context
Thirty 250-g male rats underwent 75% small intestinal resection and received s.c. injections of water [short gut (SG)-control], human growth hormone (hGH) at 0.1 mg/kg/dose [SG-low-dose (LD) GH], or hGH at 1.0 mg/kg/dose [SG-high-dose (HD) GH] every other day for 28 days.
Summary · context
Ten additional rats underwent sham operation and received water injections (sham control).
Report a problemFND-0157350901
02AnimalAnimal study (in vivo)Efficacy outcome
In rats with intestinal resection, high-dose hGH increased distal ileal weight per centimeter compared with resection controls.
In plain wordsIn rats with intestinal resection, high-dose hGH increased ileal weight per centimeter compared with resection controls.
Peptide
HGH (somatotropin)
Outcome
IncreaseDistal ileal weight per centimeter
Study
ratn: not reported in source
75% small intestinal resection
Comparator
Resection control
Outcome group
Gastrointestinal protection · Gastrointestinal
Studied dose
1.0 mg/kg/dose every other day · subcutaneous · 28 daysAs given in this study (rat).
Source sentences
Summary
Weight per centimeter of the distal ileum was greater in all SG groups compared to the sham control group, and was greater in the SG-HDGH than in the SG-control group.
2 context sentences(design, population, supporting numbers)
Summary · context
Thirty 250-g male rats underwent 75% small intestinal resection and received s.c. injections of water [short gut (SG)-control], human growth hormone (hGH) at 0.1 mg/kg/dose [SG-low-dose (LD) GH], or hGH at 1.0 mg/kg/dose [SG-high-dose (HD) GH] every other day for 28 days.
Summary · context
Ten additional rats underwent sham operation and received water injections (sham control).
Report a problemFND-0157350902
03AnimalAnimal study (in vivo)Efficacy outcome
In rats with intestinal resection, ileal mucosal DNA content did not differ between hGH-treated and other groups.
In plain wordsIn rats with intestinal resection, ileal mucosal DNA did not differ between hGH-treated and other groups.
Peptide
HGH (somatotropin)
Outcome
No significant changeIleal mucosal DNA
Study
ratn: not reported in source
75% small intestinal resection
Comparator
Other groups
Outcome group
Gastrointestinal protection · Gastrointestinal
Studied dose
0.1 and 1.0 mg/kg/dose every other day · subcutaneous · 28 daysAs given in this study (rat).
Source sentences
Summary
No differences in ileal mucosal DNA content or ileal insulin-like growth factor-1 (IGF-1) content were identified between groups.
2 context sentences(design, population, supporting numbers)
Summary · context
Thirty 250-g male rats underwent 75% small intestinal resection and received s.c. injections of water [short gut (SG)-control], human growth hormone (hGH) at 0.1 mg/kg/dose [SG-low-dose (LD) GH], or hGH at 1.0 mg/kg/dose [SG-high-dose (HD) GH] every other day for 28 days.
Summary · context
Ten additional rats underwent sham operation and received water injections (sham control).
Report a problemFND-0157350903
04AnimalAnimal study (in vivo)Efficacy outcome
In rats with intestinal resection, ileal IGF-1 content did not differ between groups.
In plain wordsIn rats with intestinal resection, ileal IGF-1 did not differ between hGH-treated and other groups.
Peptide
HGH (somatotropin)
Outcome
No significant changeIleal IGF-1
Study
ratn: not reported in source
75% small intestinal resection
Comparator
Other groups
Outcome group
Gastrointestinal protection · Gastrointestinal
Studied dose
0.1 and 1.0 mg/kg/dose every other day · subcutaneous · 28 daysAs given in this study (rat).
Source sentences
Summary
No differences in ileal mucosal DNA content or ileal insulin-like growth factor-1 (IGF-1) content were identified between groups.
2 context sentences(design, population, supporting numbers)
Summary · context
Thirty 250-g male rats underwent 75% small intestinal resection and received s.c. injections of water [short gut (SG)-control], human growth hormone (hGH) at 0.1 mg/kg/dose [SG-low-dose (LD) GH], or hGH at 1.0 mg/kg/dose [SG-high-dose (HD) GH] every other day for 28 days.
Summary · context
Ten additional rats underwent sham operation and received water injections (sham control).
Report a problemFND-0157350904
05AnimalAnimal study (in vivo)Efficacy outcome
In rats with intestinal resection, mucosal sucrase activity did not increase with hGH treatment.
In plain wordsIn rats with intestinal resection, mucosal sucrase activity did not increase with hGH treatment.
Peptide
HGH (somatotropin)
Outcome
No significant changeMucosal sucrase activity
Study
ratn: not reported in source
75% small intestinal resection
Outcome group
Gastrointestinal protection · Gastrointestinal
Studied dose
0.1 and 1.0 mg/kg/dose every other day · subcutaneous · 28 daysAs given in this study (rat).
Source sentences
Summary
Mucosal sucrase activity was not increased in hGH-treated rats.
2 context sentences(design, population, supporting numbers)
Summary · context
Thirty 250-g male rats underwent 75% small intestinal resection and received s.c. injections of water [short gut (SG)-control], human growth hormone (hGH) at 0.1 mg/kg/dose [SG-low-dose (LD) GH], or hGH at 1.0 mg/kg/dose [SG-high-dose (HD) GH] every other day for 28 days.
Summary · context
Ten additional rats underwent sham operation and received water injections (sham control).
Report a problemFND-0157350905
06AnimalAnimal study (in vivo)Efficacy outcome
In rats with intestinal resection, high-dose hGH recipients had higher serum calcium than resection controls.
In plain wordsIn rats with intestinal resection, high-dose hGH recipients had higher serum calcium than resection controls.
Peptide
HGH (somatotropin)
Outcome
IncreaseSerum calcium
Study
ratn: not reported in source
75% small intestinal resection
Comparator
Resection control
Outcome group
Electrolyte balance · Endocrine and hormones
Studied dose
1.0 mg/kg/dose every other day · subcutaneous · 28 daysAs given in this study (rat).
Source sentences
Summary
Serum calcium and phosphorus concentrations were higher in SG-HDGH rats than in SG-control animals.
2 context sentences(design, population, supporting numbers)
Summary · context
Thirty 250-g male rats underwent 75% small intestinal resection and received s.c. injections of water [short gut (SG)-control], human growth hormone (hGH) at 0.1 mg/kg/dose [SG-low-dose (LD) GH], or hGH at 1.0 mg/kg/dose [SG-high-dose (HD) GH] every other day for 28 days.
Summary · context
Ten additional rats underwent sham operation and received water injections (sham control).
Report a problemFND-0157350906
07AnimalAnimal study (in vivo)Efficacy outcome
In rats with intestinal resection, high-dose hGH recipients had higher serum phosphorus than resection controls.
In plain wordsIn rats with intestinal resection, high-dose hGH recipients had higher serum phosphorus than resection controls.
Peptide
HGH (somatotropin)
Outcome
IncreaseSerum phosphorus
Study
ratn: not reported in source
75% small intestinal resection
Comparator
Resection control
Outcome group
Electrolyte balance · Endocrine and hormones
Studied dose
1.0 mg/kg/dose every other day · subcutaneous · 28 daysAs given in this study (rat).
Source sentences
Summary
Serum calcium and phosphorus concentrations were higher in SG-HDGH rats than in SG-control animals.
2 context sentences(design, population, supporting numbers)
Summary · context
Thirty 250-g male rats underwent 75% small intestinal resection and received s.c. injections of water [short gut (SG)-control], human growth hormone (hGH) at 0.1 mg/kg/dose [SG-low-dose (LD) GH], or hGH at 1.0 mg/kg/dose [SG-high-dose (HD) GH] every other day for 28 days.
Summary · context
Ten additional rats underwent sham operation and received water injections (sham control).
Report a problemFND-0157350907
08AnimalAnimal study (in vivo)Efficacy outcome
In rats with intestinal resection, body weight did not differ between high-dose and low-dose hGH groups.
In plain wordsIn rats with intestinal resection, body weight did not differ between high-dose and low-dose hGH groups.
Peptide
HGH (somatotropin)
Outcome
No significant changeBody weight high dose versus low dose
Study
ratn: not reported in source
75% small intestinal resection
Comparator
0.1 mg/kg/dose hGH every other day
Outcome group
Body weight · Metabolic and weight
Studied dose
1.0 mg/kg/dose every other day · subcutaneous · 28 daysAs given in this study (rat).
Source sentences
Summary
After 28 days, SG-control and SG-LDGH rats weighed significantly less than the sham control group; the mean weight of the SG-HDGH group was not different from other groups.
1 context sentence(design, population, supporting numbers)
Summary · context
Thirty 250-g male rats underwent 75% small intestinal resection and received s.c. injections of water [short gut (SG)-control], human growth hormone (hGH) at 0.1 mg/kg/dose [SG-low-dose (LD) GH], or hGH at 1.0 mg/kg/dose [SG-high-dose (HD) GH] every other day for 28 days.
Report a problemFND-0157350908

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
28 Oct 2026, 02:03 UTC
Study results updated
Version 1
27 Oct 2026, 16:36 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

MeSH terms

PepBank is a research reference. Talk to a doctor before you use any peptide.