Vasoactive intestinal peptide stimulates N-acetyltransferase and hydroxyindole-O-methyltransferase activities and melatonin production in cultured rat but not in Syrian hamster pineal glands.

Moujir F, Richardson BA, Yaga K, Reiter RJ

Journal of pineal research1 Jan 1992Cited by 5 (Europe PMC)

PMID1564631DOI10.1111/j.1600-079x.1992.tb00023.xPepBankPUB-01564631

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study10

10 results from studies that gave the peptide. No result from this study comes from people.

01LabEx vivo tissueEfficacy outcome
In cultured rat pineal glands, vasoactive intestinal peptide at 1 microM increased N-acetyltransferase activity within 3 hours.
In plain wordsIn rat pineal glands in culture, VIP raised the activity of an enzyme that makes melatonin.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
IncreaseNAT activity in rat pineal glands
Study
ratn: not reported in source
Pineal gland organ culture
Outcome group
Receptor activity and mechanism · Endocrine and hormones
Studied dose
1 microM · 3 hrAs given in this study (rat).
Source sentences
Summary
When rat pineal glands were incubated with either VIP (1 microM) or isoproterenol (1 microM), a beta-adrenergic agonist, a significant increase in NAT and HIOMT activities and melatonin levels were observed within 3 hr.
1 context sentence(design, population, supporting numbers)
Summary · context
The endpoints in these studies were the activities of pineal N-acetyltransferase (NAT) and hydroxyindole-O-methyltransferase (HIOMT), as well as pineal and medium melatonin levels.
Report a problemFND-0156463101
02LabEx vivo tissueEfficacy outcome
In cultured rat pineal glands, vasoactive intestinal peptide at 1 microM increased hydroxyindole-O-methyltransferase activity within 3 hours.
In plain wordsIn rat pineal glands in culture, VIP raised the activity of a second enzyme that makes melatonin.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
IncreaseHIOMT activity in rat pineal glands
Study
ratn: not reported in source
Pineal gland organ culture
Outcome group
Receptor activity and mechanism · Endocrine and hormones
Studied dose
1 microM · 3 hrAs given in this study (rat).
Source sentences
Summary
When rat pineal glands were incubated with either VIP (1 microM) or isoproterenol (1 microM), a beta-adrenergic agonist, a significant increase in NAT and HIOMT activities and melatonin levels were observed within 3 hr.
1 context sentence(design, population, supporting numbers)
Summary · context
The endpoints in these studies were the activities of pineal N-acetyltransferase (NAT) and hydroxyindole-O-methyltransferase (HIOMT), as well as pineal and medium melatonin levels.
Report a problemFND-0156463102
03LabEx vivo tissueEfficacy outcome
In cultured rat pineal glands, vasoactive intestinal peptide at 1 microM increased melatonin levels within 3 hours.
In plain wordsIn rat pineal glands in culture, VIP raised melatonin levels.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
IncreaseMelatonin levels in rat pineal glands
Study
ratn: not reported in source
Pineal gland organ culture
Outcome group
Receptor activity and mechanism · Endocrine and hormones
Studied dose
1 microM · 3 hrAs given in this study (rat).
Source sentences
Summary
When rat pineal glands were incubated with either VIP (1 microM) or isoproterenol (1 microM), a beta-adrenergic agonist, a significant increase in NAT and HIOMT activities and melatonin levels were observed within 3 hr.
1 context sentence(design, population, supporting numbers)
Summary · context
The endpoints in these studies were the activities of pineal N-acetyltransferase (NAT) and hydroxyindole-O-methyltransferase (HIOMT), as well as pineal and medium melatonin levels.
Report a problemFND-0156463103
04LabEx vivo tissueEfficacy outcome
In cultured Syrian hamster pineal glands during the day, vasoactive intestinal peptide at 1 microM did not stimulate N-acetyltransferase activity.
In plain wordsIn hamster pineal glands in culture, VIP did not raise an enzyme that makes melatonin during the day.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
No significant changeNAT activity in hamster pineal glands (daytime)
Study
Syrian hamstern: not reported in source
Pineal gland organ culture
Outcome group
Receptor activity and mechanism · Endocrine and hormones
Studied dose
1 microM · 2-8 hrAs given in this study (Syrian hamster).
Source sentences
Summary
Conversely, during the day, VIP (1 microM) was ineffective in stimulating these parameters in hamster pineal gland after incubation times of either 2, 4, 6, or 8 hr.
1 context sentence(design, population, supporting numbers)
Summary · context
The endpoints in these studies were the activities of pineal N-acetyltransferase (NAT) and hydroxyindole-O-methyltransferase (HIOMT), as well as pineal and medium melatonin levels.
Report a problemFND-0156463104
05LabEx vivo tissueEfficacy outcome
In cultured Syrian hamster pineal glands during the day, vasoactive intestinal peptide at 1 microM did not stimulate hydroxyindole-O-methyltransferase activity.
In plain wordsIn hamster pineal glands in culture, VIP did not raise a second melatonin enzyme during the day.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
No significant changeHIOMT activity in hamster pineal glands (daytime)
Study
Syrian hamstern: not reported in source
Pineal gland organ culture
Outcome group
Receptor activity and mechanism · Endocrine and hormones
Studied dose
1 microM · 2-8 hrAs given in this study (Syrian hamster).
Source sentences
Summary
Conversely, during the day, VIP (1 microM) was ineffective in stimulating these parameters in hamster pineal gland after incubation times of either 2, 4, 6, or 8 hr.
1 context sentence(design, population, supporting numbers)
Summary · context
The endpoints in these studies were the activities of pineal N-acetyltransferase (NAT) and hydroxyindole-O-methyltransferase (HIOMT), as well as pineal and medium melatonin levels.
Report a problemFND-0156463105
06LabEx vivo tissueEfficacy outcome
In cultured Syrian hamster pineal glands during the day, vasoactive intestinal peptide at 1 microM did not stimulate melatonin levels.
In plain wordsIn hamster pineal glands in culture, VIP did not raise melatonin during the day.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
No significant changeMelatonin levels in hamster pineal glands (daytime)
Study
Syrian hamstern: not reported in source
Pineal gland organ culture
Outcome group
Receptor activity and mechanism · Endocrine and hormones
Studied dose
1 microM · 2-8 hrAs given in this study (Syrian hamster).
Source sentences
Summary
Conversely, during the day, VIP (1 microM) was ineffective in stimulating these parameters in hamster pineal gland after incubation times of either 2, 4, 6, or 8 hr.
1 context sentence(design, population, supporting numbers)
Summary · context
The endpoints in these studies were the activities of pineal N-acetyltransferase (NAT) and hydroxyindole-O-methyltransferase (HIOMT), as well as pineal and medium melatonin levels.
Report a problemFND-0156463106
07LabEx vivo tissueEfficacy outcome
In cultured Syrian hamster pineal glands collected in the late dark period, vasoactive intestinal peptide did not stimulate N-acetyltransferase activity.
In plain wordsIn hamster pineal glands in culture at night, VIP did not raise a melatonin enzyme.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
No significant changeNAT activity in hamster pineal glands (night)
Study
Syrian hamstern: not reported in source
Pineal gland organ culture
Outcome group
Receptor activity and mechanism · Endocrine and hormones
Studied dose
Dose not stated
Source sentences
Summary
VIP was ineffective in stimulating either NAT or HIOMT activities
1 context sentence(design, population, supporting numbers)
Summary · context
The endpoints in these studies were the activities of pineal N-acetyltransferase (NAT) and hydroxyindole-O-methyltransferase (HIOMT), as well as pineal and medium melatonin levels.
Report a problemFND-0156463107
08LabEx vivo tissueEfficacy outcome
In cultured Syrian hamster pineal glands collected in the late dark period, vasoactive intestinal peptide did not stimulate hydroxyindole-O-methyltransferase activity.
In plain wordsIn hamster pineal glands in culture at night, VIP did not raise a second melatonin enzyme.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
No significant changeHIOMT activity in hamster pineal glands (night)
Study
Syrian hamstern: not reported in source
Pineal gland organ culture
Outcome group
Receptor activity and mechanism · Endocrine and hormones
Studied dose
Dose not stated
Source sentences
Summary
VIP was ineffective in stimulating either NAT or HIOMT activities
1 context sentence(design, population, supporting numbers)
Summary · context
The endpoints in these studies were the activities of pineal N-acetyltransferase (NAT) and hydroxyindole-O-methyltransferase (HIOMT), as well as pineal and medium melatonin levels.
Report a problemFND-0156463108
09LabEx vivo tissueEfficacy outcome
In cultured Syrian hamster pineal glands at night, vasoactive intestinal peptide had no stimulatory effect on pineal melatonin levels.
In plain wordsIn hamster pineal glands in culture at night, VIP did not raise melatonin.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
No significant changeMelatonin levels in hamster pineal glands (night)
Study
Syrian hamstern: not reported in source
Pineal gland organ culture
Outcome group
Receptor activity and mechanism · Endocrine and hormones
Studied dose
Dose not stated
Source sentences
Summary
likewise, VIP had no stimulatory effect on pineal melatonin levels at night.
1 context sentence(design, population, supporting numbers)
Summary · context
The endpoints in these studies were the activities of pineal N-acetyltransferase (NAT) and hydroxyindole-O-methyltransferase (HIOMT), as well as pineal and medium melatonin levels.
Report a problemFND-0156463109
10LabEx vivo tissueEfficacy outcome
In cultured Syrian hamster pineal glands at night, vasoactive intestinal peptide from 10 nM to 100 microM changed no parameter of melatonin synthesis.
In plain wordsIn hamster pineal glands in culture, no VIP dose from low to high changed melatonin production.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
No significant changeMelatonin synthesis parameters at 10 nM to 100 microM VIP in hamster pineal glands
Study
Syrian hamstern: not reported in source
Pineal gland organ culture
Outcome group
Receptor activity and mechanism · Endocrine and hormones
Studied dose
0, 10 nM, 100 nM, 10 microM, 100 microMAs given in this study (Syrian hamster).
Source sentences
Summary
Finally, when hamster pineal glands at night were incubated with either 0, 10 nM, 100 nM, 10 microM, or 100 microM VIP, no changes in any parameter of melatonin synthesis were measured.
1 context sentence(design, population, supporting numbers)
Summary · context
The endpoints in these studies were the activities of pineal N-acetyltransferase (NAT) and hydroxyindole-O-methyltransferase (HIOMT), as well as pineal and medium melatonin levels.
Report a problemFND-0156463110

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
12 Oct 2026, 12:58 UTC
Study results updated
Version 1
9 Oct 2026, 12:41 UTC
First added · source update from Europe PMC

PepBank is a research reference. Talk to a doctor before you use any peptide.

Vasoactive intestinal peptide stimulates N-acetyltransferase and hydroxyindole-O-methyltransferase activities and melatonin production in cultured rat but not in Syrian hamster pineal glands.

Summary

Results from this study10

Version history

Subjects

Publication types

MeSH terms