Radioprotective effects of serum thymic factor in mice.

Kobayashi H, Abe H, Ueyama T, Awaya A, Shikita M

Radiation research1 Mar 1992Cited by 4 (Europe PMC)

PMID1542723DOI10.2307/3578036PepBankPUB-01542723

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study14

14 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In mice after total-body irradiation, daily FTS reduced mortality at radioprotective doses.
In plain wordsIn mice after irradiation, daily FTS reduced deaths.
Peptide
Thymulin (serum thymic factor)
Outcome
DecreaseMortality after irradiation
Study
mousen: not reported in source
Total-body X-irradiated mice
Outcome group
Mortality · Whole body
Studied dose
3-100 micrograms daily · subcutaneousAs given in this study (mouse).
Source sentences
Summary
Serum thymic factor (FTS) reduced mortality of mice after total-body irradiation with 7.56 Gy X rays.
1 context sentence(design, population, supporting numbers)
Summary · context
The radioprotective effect was achieved by daily repeated subcutaneous injections of 3-100 micrograms FTS, while doses higher than 300 micrograms/day/mouse were neither radioprotective nor toxic.
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02AnimalAnimal study (in vivo)Efficacy outcome
In irradiated mice, FTS doses higher than 300 micrograms/day/mouse were not radioprotective.
In plain wordsIn irradiated mice, FTS doses higher than 300 micrograms/day/mouse did not provide radioprotection.
Peptide
Thymulin (serum thymic factor)
Outcome
No significant changeRadioprotection at high doses
Study
mousen: not reported in source
Total-body X-irradiated mice
Outcome group
Mortality · Whole body
Studied dose
>300 micrograms/day/mouse · subcutaneousAs given in this study (mouse).
Source sentences
Summary
The radioprotective effect was achieved by daily repeated subcutaneous injections of 3-100 micrograms FTS, while doses higher than 300 micrograms/day/mouse were neither radioprotective nor toxic.
Report a problemFND-0154272302
03AnimalAnimal study (in vivo)Safety outcome
In mice, FTS doses higher than 300 micrograms/day/mouse were not toxic.
In plain wordsIn mice, FTS doses higher than 300 micrograms/day/mouse were not toxic.
Peptide
Thymulin (serum thymic factor)
Outcome
No significant changeHigh-dose toxicity
Study
mousen: not reported in source
Total-body X-irradiated mice
Outcome group
Adverse events · Whole body
Studied dose
>300 micrograms/day/mouse · subcutaneousAs given in this study (mouse).
Source sentences
Summary
The radioprotective effect was achieved by daily repeated subcutaneous injections of 3-100 micrograms FTS, while doses higher than 300 micrograms/day/mouse were neither radioprotective nor toxic.
Report a problemFND-0154272303
04AnimalAnimal study (in vivo)Efficacy outcome
In sublethally irradiated mice, FTS moderated spleen degeneration at 3-100 micrograms.
In plain wordsIn sublethally irradiated mice, FTS reduced spleen degeneration at 3-100 micrograms.
Peptide
Thymulin (serum thymic factor)
Outcome
DecreaseSpleen degeneration at lower doses
Study
mousen: not reported in source
Total-body X-irradiated mice
Outcome group
Immune response · Immune and inflammation
Studied dose
3-100 micrograms · subcutaneousAs given in this study (mouse).
Source sentences
Summary
Similarly, degeneration of the spleen was moderated by 3-100 micrograms FTS but not by 500 micrograms FTS in sublethally (3.78 Gy) irradiated mice.
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05AnimalAnimal study (in vivo)Efficacy outcome
In sublethally irradiated mice, 500 micrograms FTS did not moderate spleen degeneration.
In plain wordsIn sublethally irradiated mice, 500 micrograms FTS did not reduce spleen degeneration.
Peptide
Thymulin (serum thymic factor)
Outcome
No significant changeSpleen degeneration at high dose
Study
mousen: not reported in source
Total-body X-irradiated mice
Outcome group
Immune response · Immune and inflammation
Studied dose
500 micrograms · subcutaneousAs given in this study (mouse).
Source sentences
Summary
Similarly, degeneration of the spleen was moderated by 3-100 micrograms FTS but not by 500 micrograms FTS in sublethally (3.78 Gy) irradiated mice.
Report a problemFND-0154272305
06AnimalAnimal study (in vivo)Efficacy outcome
In irradiated mice, daily FTS enhanced splenic hematopoiesis.
In plain wordsIn irradiated mice, daily FTS increased blood-cell production in the spleen.
Peptide
Thymulin (serum thymic factor)
Outcome
IncreaseSplenic hematopoiesis
Study
mousen: not reported in source
Total-body X-irradiated mice
Outcome group
Immune response · Immune and inflammation
Studied dose
10 micrograms daily · subcutaneousAs given in this study (mouse).
Source sentences
Summary
Histological examination showed that hematopoiesis was enhanced in the spleen by daily injections of 10 micrograms FTS.
Report a problemFND-0154272306
07AnimalAnimal study (in vivo)Efficacy outcome
Spleen cells from FTS-treated mice incorporated more thymidine in culture with or without concanavalin A.
In plain wordsIn mice, FTS treatment increased subsequent thymidine incorporation by spleen cells in cultures with or without concanavalin A.
Peptide
Thymulin (serum thymic factor)
Outcome
IncreaseSplenic cell thymidine incorporation
Study
mousen: not reported in source
Total-body X-irradiated mice
Outcome group
Immune response · Immune and inflammation
Studied dose
Dose not stated · subcutaneousAs given in this study (mouse).
Source sentences
Summary
Spleen cells from the FTS-treated mice incorporated more [3H]thymidine in culture with or without concanavalin A.
Report a problemFND-0154272307
08AnimalAnimal study (in vivo)Efficacy outcome
In irradiated mice, FTS increased colony-stimulating factor production in the spleen.
In plain wordsIn irradiated mice, FTS increased colony-stimulating factor production in the spleen.
Peptide
Thymulin (serum thymic factor)
Outcome
IncreaseSplenic colony-stimulating factor production
Study
mousen: not reported in source
Total-body X-irradiated mice
Outcome group
Immune response · Immune and inflammation
Studied dose
Dose not stated · subcutaneousAs given in this study (mouse).
Source sentences
Summary
The treatment with FTS increased the production of colony-stimulating factor in the spleen as well as in peritoneal macrophage-like cells, and caused a significant increase in the number of granulocyte-macrophage colony-forming cells both in the spleen and in the femoral bone marrow.
Report a problemFND-0154272308
09AnimalAnimal study (in vivo)Efficacy outcome
In irradiated mice, FTS increased colony-stimulating factor production in peritoneal macrophage-like cells.
In plain wordsIn irradiated mice, FTS increased colony-stimulating factor production in peritoneal macrophage-like cells.
Peptide
Thymulin (serum thymic factor)
Outcome
IncreasePeritoneal colony-stimulating factor production
Study
mousen: not reported in source
Total-body X-irradiated mice
Outcome group
Immune response · Immune and inflammation
Studied dose
Dose not stated · subcutaneousAs given in this study (mouse).
Source sentences
Summary
The treatment with FTS increased the production of colony-stimulating factor in the spleen as well as in peritoneal macrophage-like cells, and caused a significant increase in the number of granulocyte-macrophage colony-forming cells both in the spleen and in the femoral bone marrow.
Report a problemFND-0154272309
10AnimalAnimal study (in vivo)Efficacy outcome
In irradiated mice, FTS significantly increased splenic granulocyte-macrophage colony-forming cell numbers.
In plain wordsIn irradiated mice, FTS increased granulocyte-macrophage colony-forming cells in the spleen.
Peptide
Thymulin (serum thymic factor)
Outcome
IncreaseSplenic granulocyte-macrophage colony-forming cells
Study
mousen: not reported in source
Total-body X-irradiated mice
Outcome group
Immune response · Immune and inflammation
Studied dose
Dose not stated · subcutaneousAs given in this study (mouse).
Source sentences
Summary
The treatment with FTS increased the production of colony-stimulating factor in the spleen as well as in peritoneal macrophage-like cells, and caused a significant increase in the number of granulocyte-macrophage colony-forming cells both in the spleen and in the femoral bone marrow.
Report a problemFND-0154272310
11AnimalAnimal study (in vivo)Efficacy outcome
In irradiated mice, FTS significantly increased granulocyte-macrophage colony-forming cells in femoral bone marrow.
In plain wordsIn irradiated mice, FTS increased granulocyte-macrophage colony-forming cells in bone marrow.
Peptide
Thymulin (serum thymic factor)
Outcome
IncreaseBone marrow granulocyte-macrophage colony-forming cells
Study
mousen: not reported in source
Total-body X-irradiated mice
Outcome group
Immune response · Immune and inflammation
Studied dose
Dose not stated · subcutaneousAs given in this study (mouse).
Source sentences
Summary
The treatment with FTS increased the production of colony-stimulating factor in the spleen as well as in peritoneal macrophage-like cells, and caused a significant increase in the number of granulocyte-macrophage colony-forming cells both in the spleen and in the femoral bone marrow.
Report a problemFND-0154272311
12AnimalAnimal study (in vivo)Efficacy outcome
In sublethally irradiated mice, FTS prevented the decrease in circulating neutrophils.
In plain wordsIn sublethally irradiated mice, FTS prevented a decrease in circulating neutrophils.
Peptide
Thymulin (serum thymic factor)
Outcome
IncreaseCirculating neutrophil decrease
Study
mousen: not reported in source
Total-body X-irradiated mice
Outcome group
Immune response · Immune and inflammation
Studied dose
Dose not stated · subcutaneousAs given in this study (mouse).
Source sentences
Summary
Furthermore, FTS prevented a decrease in circulating neutrophils in the sublethally irradiated mice.
Report a problemFND-0154272312
13AnimalAnimal study (in vivo)Efficacy outcome
In sublethally irradiated mice, occasional prominent myelopoiesis overshoot recovery did not occur with FTS treatment.
In plain wordsIn sublethally irradiated mice, FTS-treated animals did not show the occasional overshoot in blood-cell production.
Peptide
Thymulin (serum thymic factor)
Outcome
DecreaseMyelopoiesis overshoot recovery
Study
mousen: not reported in source
Total-body X-irradiated mice
Outcome group
Immune response · Immune and inflammation
Studied dose
Dose not stated · subcutaneousAs given in this study (mouse).
Source sentences
Summary
Prominent overshoot recovery of myelopoiesis, which occurred occasionally in sublethally irradiated mice, did not occur in the FTS-treated mice.
Report a problemFND-0154272313
14AnimalAnimal study (in vivo)Efficacy outcome
In irradiated mice, FTS significantly reduced the decrease in blood erythrocytes.
In plain wordsIn irradiated mice, FTS reduced the loss of red blood cells.
Peptide
Thymulin (serum thymic factor)
Outcome
IncreaseBlood erythrocyte decrease
Study
mousen: not reported in source
Total-body X-irradiated mice
Outcome group
Immune response · Immune and inflammation
Studied dose
Dose not stated · subcutaneousAs given in this study (mouse).
Source sentences
Summary
The decrease in blood erythrocytes was also significantly reduced.
Report a problemFND-0154272314

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
21 Oct 2026, 15:58 UTC
Study results updated
Version 1
21 Oct 2026, 12:50 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

Journal Article

MeSH terms

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