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Study · Measured the body's own peptide · 1992

2 results

Pituitary adenylate cyclase activating peptide: a novel vasoactive intestinal peptide-like neuropeptide in the gut.

Sundler F, Ekblad E, Absood A, Håkanson R, Köves K, Arimura A

Neuroscience1 Jan 1992Cited by 188 (Europe PMC)

PMID1542417 (opens in a new tab)DOI10.1016/0306-4522(92)90064-9 (opens in a new tab)PepBankPUB-01542417
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

No result from this study comes from a test of the peptide.

Natural levels measured2

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

  1. 01LabEndogenous levelEx vivo tissueOther

    Double immunostaining showed that the body's own vasoactive intestinal peptide and PACAP co-existed in nerve cell bodies and fibers of the human and chicken gut, and in fibers of the mouse and rat gastric mucosa.

    In plain wordsIn tissue samples from several species, the body's own VIP and PACAP were found together in some gut nerves.

    Peptide
    Vasoactive intestinal peptide (VIP, aviptadil)
    Outcome
    Not applicableCo-existence of VIP and PACAP in gut nerves
    Study

    human, chicken, mouse, ratn: not reported in source

    Gut tissue immunocytochemistry
    Outcome group
    Endogenous peptide levels · Gastrointestinal

    Source sentences

    Summary
    Double immunostaining for VIP and PACAP revealed co-existence of the two peptides in nerve cell bodies and nerve fibers of the human and chicken gut and in fibers in the gastric mucosa of mouse and rat.
    1 context sentence
    Summary · context
    In the present study, the occurrence and distribution of PACAP-like peptides were examined in the gut of several species by immunocytochemistry and immunochemistry using an antibody raised against PACAP-27.

    This result measures the body's own Vasoactive intestinal peptide (VIP, aviptadil). Nobody was given the peptide. It is not evidence about taking it.

  2. 02LabEndogenous levelEx vivo tissueOther

    In all other species and gut locations examined, PACAP-immunoreactive nerves were distinct from those storing the body's own vasoactive intestinal peptide.

    In plain wordsIn tissue samples, PACAP and the body's own VIP were found in different gut nerves in all other species and locations.

    Peptide
    Vasoactive intestinal peptide (VIP, aviptadil)
    Outcome
    Not applicableSeparate localisation of VIP and PACAP in other species and locations
    Study

    multiple speciesn: not reported in source

    Gut tissue immunocytochemistry
    Outcome group
    Endogenous peptide levels · Gastrointestinal

    Source sentences

    Summary
    In all other species examined and in all other locations in the gut PACAP-immunoreactive nerve cell bodies and nerve fibers were distinct from those storing VIP; many of them contained gastrin-releasing peptide instead.
    1 context sentence
    Summary · context
    In the present study, the occurrence and distribution of PACAP-like peptides were examined in the gut of several species by immunocytochemistry and immunochemistry using an antibody raised against PACAP-27.

    This result measures the body's own Vasoactive intestinal peptide (VIP, aviptadil). Nobody was given the peptide. It is not evidence about taking it.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    12 Oct 2026, 12:58 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 12:41 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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