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Study · Animal study (in vivo) · mouse · 1992

2 results

Effect of synthetic thymic humoral factor (THF-gamma 2) on T cell activities in immunodeficient ageing mice.

Goso C, Frasca D, Doria G

Clinical and experimental immunology1 Mar 1992Cited by 20 (Europe PMC)

PMID1531947 (opens in a new tab)DOI10.1111/j.1365-2249.1992.tb03000.x (opens in a new tab)PepBankPUB-01531947
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In immunodeficient ageing mice, the effect of thymosin alpha‑1 on T helper cell activity increased with increasing injected dose.

    In plain wordsIn ageing mice, thymosin alpha‑1 had a larger effect on helper T cell activity at higher doses.

    Peptide
    Thymosin alpha-1
    Outcome
    IncreaseT helper cell activity of spleen cells
    Study

    mousen: not reported in source

    immunodeficient ageing (C57BL/10 x DBA/2)F1 mice
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Dose not stated · injection · single injectionAs given in this study (mouse).

    Source sentences

    Summary
    the effects of thymopentin and thymosin-alpha 1 on T helper cell activity increased with increasing the injected dose
    1 context sentence
    Summary · context
    Immunodeficient ageing (C57BL/10 x DBA/2)F1 mice were treated by a single injection of synthetic thymic hormones and 4 days later their thymus and spleen cells were assayed in vitro for T cell activities.
  2. 02AnimalAnimal study (in vivo)Activity measurement

    In immunodeficient ageing mice, THF-gamma 2 was 400-fold and thymopentin eight-fold more efficient than thymosin alpha‑1 on T helper cell activity.

    In plain wordsIn ageing mice, thymosin alpha‑1 was much less potent than THF-gamma 2 and thymopentin at boosting helper T cell activity.

    Peptide
    Thymosin alpha-1
    Outcome
    Not applicableRelative efficiency on T helper cell activity
    Study

    mousen: not reported in source

    immunodeficient ageing (C57BL/10 x DBA/2)F1 mice
    Comparator
    THF-gamma 2; thymopentin
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Dose not stated · injection · single injectionAs given in this study (mouse).

    Source sentences

    Summary
    but the efficiencies of THF-gamma 2 and thymopentin were, respectively, 400-fold and eight-fold greater than that of thymosin-alpha 1.
    1 context sentence
    Summary · context
    Immunodeficient ageing (C57BL/10 x DBA/2)F1 mice were treated by a single injection of synthetic thymic hormones and 4 days later their thymus and spleen cells were assayed in vitro for T cell activities.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    10 Oct 2026, 08:55 UTC

    Study results updated

  2. Version 2

    9 Oct 2026, 03:03 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    9 Oct 2026, 03:02 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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