Therapy with human chorionic gonadotrophin alone induces spermatogenesis in men with isolated hypogonadotrophic hypogonadism--long-term follow-up.

Vicari E, Mongioì A, Calogero AE, Moncada ML, Sidoti G, Polosa P, D'Agata R

International journal of andrology1 Aug 1992Cited by 95 (Europe PMC)

PMID1516981DOI10.1111/j.1365-2605.1992.tb01131.xPepBankPUB-01516981

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study19

13 results from studies that gave the peptide. 13 results from people.

01HumanNon-randomized trialEfficacy outcome
In men with isolated hypogonadotrophic hypogonadism, hCG increased mean testicular volume from 3.8 ml to a maximal 14.9 ml.
In plain wordsIn men with hypogonadotrophic hypogonadism, hCG increased testicular volume compared with baseline.
Peptide
hCG (human chorionic gonadotropin)
Outcome
IncreaseTesticular volume
Study
n = 17
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
Dose not stated · 14-120 monthsAs given in this study (human).
Measurements
Mean testicular volume, baseline
3.8 ml
17 men with isolated hypogonadotrophic hypogonadism, before hCG
Mean maximal testicular volume
14.9 ml
after 22.2 +/- 2.3 months of hCG treatment
SEM of baseline mean testicular volume
0.2 ml
before hCG treatment, mean 3.8 ml
SEM of maximal mean testicular volume
1.1 ml
after hCG treatment, mean 14.9 ml
Source sentences
Summary
Mean testicular volume increased from 3.8 +/- 0.2 (Mean +/- SEM) ml to a maximal of 14.9 +/- 1.1 ml after 22.2 +/- 2.3 months of hCG treatment.
1 context sentence(design, population, supporting numbers)
Summary · context
The effects of long-term (14-120 months) hCG-treatment of 17 male patients affected by isolated hypogonadotrophic hypogonadism (IHH) on testicular volume, plasma testosterone levels, and sperm concentration were assessed.
Report a problemFND-0151698101
02HumanNon-randomized trialOther
In men receiving hCG for isolated hypogonadotrophic hypogonadism, maximal testicular volume correlated positively with pretreatment volume.
In plain wordsIn men receiving hCG, larger pretreatment testes were linked to larger maximal testicular volume.
Peptide
hCG (human chorionic gonadotropin)
Outcome
IncreaseMaximum volume and pretreatment volume
Study
n = 17
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
Dose not stated · 14-120 monthsAs given in this study (human).
Source sentences
Summary
Maximal testicular volume correlated positively with the volume recorded before the patients had undergone any previous treatment.
1 context sentence(design, population, supporting numbers)
Summary · context
The effects of long-term (14-120 months) hCG-treatment of 17 male patients affected by isolated hypogonadotrophic hypogonadism (IHH) on testicular volume, plasma testosterone levels, and sperm concentration were assessed.
Report a problemFND-0151698102
03HumanNon-randomized trialEfficacy outcome
In men receiving hCG for isolated hypogonadotrophic hypogonadism, testicular volumes were consistently greater in the large than small testis subset.
In plain wordsIn men receiving hCG, testicular volumes remained greater in the large than small testis subset.
Peptide
hCG (human chorionic gonadotropin)
Outcome
IncreaseTesticular volume by initial size
Study
n = 17
Comparator
Small testis subset
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
Dose not stated · 14-120 monthsAs given in this study (human).
Source sentences
Summary
Testicular volumes in the LTS group were always greater than those of the STS.
3 context sentences(design, population, supporting numbers)
Summary · context
Testicular growth was also analysed by sorting the patients into two sub-groups according to whether their initial testicular volume was less than 4 ml (small testis subset, STS) or greater than or equal to 4 ml (large testis subset, LTS), supposedly indicating complete or partial gonadotrophin defi…
Summary · context
Thirteen patients (70%) became sperm-positive during treatment with hCG alone; five out of eight (60%) were STS patients and eight out of nine (90%) were LTS.
Summary · context
The effects of long-term (14-120 months) hCG-treatment of 17 male patients affected by isolated hypogonadotrophic hypogonadism (IHH) on testicular volume, plasma testosterone levels, and sperm concentration were assessed.
Report a problemFND-0151698103
04HumanNon-randomized trialEfficacy outcome
In men with isolated hypogonadotrophic hypogonadism, plasma testosterone reached adult values during hCG treatment.
In plain wordsIn men with hypogonadotrophic hypogonadism, testosterone reached adult values during hCG treatment.
Peptide
hCG (human chorionic gonadotropin)
Outcome
IncreaseTestosterone normalization
Study
n = 17
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
Dose not stated · 14-120 monthsAs given in this study (human).
Source sentences
Summary
Plasma testosterone levels reached adulthood values during hCG treatment and no statistically significant difference was detected between LTS and STS patients with IHH.
1 context sentence(design, population, supporting numbers)
Summary · context
The effects of long-term (14-120 months) hCG-treatment of 17 male patients affected by isolated hypogonadotrophic hypogonadism (IHH) on testicular volume, plasma testosterone levels, and sperm concentration were assessed.
Report a problemFND-0151698104
05HumanNon-randomized trialEfficacy outcome
In men receiving hCG for isolated hypogonadotrophic hypogonadism, testosterone did not differ significantly between large and small testis subsets.
In plain wordsIn men receiving hCG, testosterone levels did not differ significantly between large and small testis subsets.
Peptide
hCG (human chorionic gonadotropin)
Outcome
No significant changeTestosterone by initial testis size
Study
n = 17
Comparator
Small testis subset
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
Dose not stated · 14-120 monthsAs given in this study (human).
Source sentences
Summary
Plasma testosterone levels reached adulthood values during hCG treatment and no statistically significant difference was detected between LTS and STS patients with IHH.
2 context sentences(design, population, supporting numbers)
Summary · context
Thirteen patients (70%) became sperm-positive during treatment with hCG alone; five out of eight (60%) were STS patients and eight out of nine (90%) were LTS.
Summary · context
The effects of long-term (14-120 months) hCG-treatment of 17 male patients affected by isolated hypogonadotrophic hypogonadism (IHH) on testicular volume, plasma testosterone levels, and sperm concentration were assessed.
Report a problemFND-0151698105
06HumanNon-randomized trialEfficacy outcome
In men with isolated hypogonadotrophic hypogonadism, thirteen patients (70%) became sperm-positive with hCG alone.
In plain wordsIn men with hypogonadotrophic hypogonadism, hCG alone produced positive sperm counts in thirteen patients.
Peptide
hCG (human chorionic gonadotropin)
Outcome
IncreaseSperm-positive patients
Study
n = 17
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
Dose not stated · 14-120 monthsAs given in this study (human).
Measurements
Sperm-positive patients
13 patients
during hCG alone, men with isolated hypogonadotrophic hypogonadism
Sperm-positive patients
70%
during hCG alone, men with isolated hypogonadotrophic hypogonadism
Source sentences
Summary
Thirteen patients (70%) became sperm-positive during treatment with hCG alone; five out of eight (60%) were STS patients and eight out of nine (90%) were LTS.
1 context sentence(design, population, supporting numbers)
Summary · context
The effects of long-term (14-120 months) hCG-treatment of 17 male patients affected by isolated hypogonadotrophic hypogonadism (IHH) on testicular volume, plasma testosterone levels, and sperm concentration were assessed.
Report a problemFND-0151698106
07HumanNon-randomized trialEfficacy outcome
In men receiving hCG for isolated hypogonadotrophic hypogonadism, the large testis subset consistently had greater sperm output than the small subset.
In plain wordsIn men receiving hCG, the large testis subset consistently had greater sperm output than the small subset.
Peptide
hCG (human chorionic gonadotropin)
Outcome
IncreaseSperm output by initial size
Study
n = 17
Comparator
Small testis subset
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
Dose not stated · 14-120 monthsAs given in this study (human).
Source sentences
Summary
In addition, LTS patients always had a greater sperm output than did STS patients.
2 context sentences(design, population, supporting numbers)
Summary · context
Thirteen patients (70%) became sperm-positive during treatment with hCG alone; five out of eight (60%) were STS patients and eight out of nine (90%) were LTS.
Summary · context
The effects of long-term (14-120 months) hCG-treatment of 17 male patients affected by isolated hypogonadotrophic hypogonadism (IHH) on testicular volume, plasma testosterone levels, and sperm concentration were assessed.
Report a problemFND-0151698109
08HumanNon-randomized trialOther
In men receiving hCG for isolated hypogonadotrophic hypogonadism, sperm concentration correlated positively with maximal testicular volume.
In plain wordsIn men receiving hCG, higher sperm concentration was linked to larger maximal testicular volume.
Peptide
hCG (human chorionic gonadotropin)
Outcome
IncreaseSperm concentration and maximal volume
Study
n = 17
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
Dose not stated · 14-120 monthsAs given in this study (human).
Source sentences
Summary
Sperm concentration correlated positively with maximal testicular volume, but not with patient age, length of treatment, or initial testicular volume.
1 context sentence(design, population, supporting numbers)
Summary · context
The effects of long-term (14-120 months) hCG-treatment of 17 male patients affected by isolated hypogonadotrophic hypogonadism (IHH) on testicular volume, plasma testosterone levels, and sperm concentration were assessed.
Report a problemFND-0151698110
09HumanNon-randomized trialOther
In men receiving hCG for isolated hypogonadotrophic hypogonadism, sperm concentration did not correlate with patient age.
In plain wordsIn men receiving hCG, sperm concentration was not linked to patient age.
Peptide
hCG (human chorionic gonadotropin)
Outcome
No significant changeSperm concentration and patient age
Study
n = 17
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
Dose not stated · 14-120 monthsAs given in this study (human).
Source sentences
Summary
Sperm concentration correlated positively with maximal testicular volume, but not with patient age, length of treatment, or initial testicular volume.
1 context sentence(design, population, supporting numbers)
Summary · context
The effects of long-term (14-120 months) hCG-treatment of 17 male patients affected by isolated hypogonadotrophic hypogonadism (IHH) on testicular volume, plasma testosterone levels, and sperm concentration were assessed.
Report a problemFND-0151698111
10HumanNon-randomized trialOther
In men receiving hCG for isolated hypogonadotrophic hypogonadism, sperm concentration did not correlate with treatment length.
In plain wordsIn men receiving hCG, sperm concentration was not linked to treatment length.
Peptide
hCG (human chorionic gonadotropin)
Outcome
No significant changeSperm concentration and treatment length
Study
n = 17
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
Dose not stated · 14-120 monthsAs given in this study (human).
Source sentences
Summary
Sperm concentration correlated positively with maximal testicular volume, but not with patient age, length of treatment, or initial testicular volume.
1 context sentence(design, population, supporting numbers)
Summary · context
The effects of long-term (14-120 months) hCG-treatment of 17 male patients affected by isolated hypogonadotrophic hypogonadism (IHH) on testicular volume, plasma testosterone levels, and sperm concentration were assessed.
Report a problemFND-0151698112
11HumanNon-randomized trialOther
In men receiving hCG for isolated hypogonadotrophic hypogonadism, sperm concentration did not correlate with initial testicular volume.
In plain wordsIn men receiving hCG, sperm concentration was not linked to initial testicular volume.
Peptide
hCG (human chorionic gonadotropin)
Outcome
No significant changeSperm concentration and initial volume
Study
n = 17
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
Dose not stated · 14-120 monthsAs given in this study (human).
Source sentences
Summary
Sperm concentration correlated positively with maximal testicular volume, but not with patient age, length of treatment, or initial testicular volume.
1 context sentence(design, population, supporting numbers)
Summary · context
The effects of long-term (14-120 months) hCG-treatment of 17 male patients affected by isolated hypogonadotrophic hypogonadism (IHH) on testicular volume, plasma testosterone levels, and sperm concentration were assessed.
Report a problemFND-0151698113
12HumanNon-randomized trialEfficacy outcome
In the large testis subset with isolated hypogonadotrophic hypogonadism, eight of nine patients (90%) became sperm-positive with hCG alone.
In plain wordsIn men with initially larger testes, eight of nine became sperm-positive with hCG alone.
Peptide
hCG (human chorionic gonadotropin)
Outcome
IncreaseSperm-positive large testis subset
Study
n = 9
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
Dose not stated · 14-120 monthsAs given in this study (human).
Measurements
Sperm-positive patients
8 patients
large testis subset, hCG alone, of 9
Sperm-positive patients
90%
large testis subset, hCG alone
Source sentences
Summary
Thirteen patients (70%) became sperm-positive during treatment with hCG alone; five out of eight (60%) were STS patients and eight out of nine (90%) were LTS.
2 context sentences(design, population, supporting numbers)
Summary · context
Testicular growth was also analysed by sorting the patients into two sub-groups according to whether their initial testicular volume was less than 4 ml (small testis subset, STS) or greater than or equal to 4 ml (large testis subset, LTS), supposedly indicating complete or partial gonadotrophin defi…
Summary · context
The effects of long-term (14-120 months) hCG-treatment of 17 male patients affected by isolated hypogonadotrophic hypogonadism (IHH) on testicular volume, plasma testosterone levels, and sperm concentration were assessed.
Report a problemFND-0151698108
13HumanNon-randomized trialEfficacy outcome
In the small testis subset with isolated hypogonadotrophic hypogonadism, five of eight patients (60%) became sperm-positive with hCG alone.
In plain wordsIn men with initially small testes, five of eight became sperm-positive with hCG alone.
Peptide
hCG (human chorionic gonadotropin)
Outcome
IncreaseSperm-positive small testis subset
Study
n = 8
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
Dose not stated · 14-120 monthsAs given in this study (human).
Measurements
Sperm-positive patients
5 patients
small testis subset, hCG alone, of 8
Sperm-positive patients
60%
small testis subset, hCG alone
Source sentences
Summary
Thirteen patients (70%) became sperm-positive during treatment with hCG alone; five out of eight (60%) were STS patients and eight out of nine (90%) were LTS.
2 context sentences(design, population, supporting numbers)
Summary · context
Testicular growth was also analysed by sorting the patients into two sub-groups according to whether their initial testicular volume was less than 4 ml (small testis subset, STS) or greater than or equal to 4 ml (large testis subset, LTS), supposedly indicating complete or partial gonadotrophin defi…
Summary · context
The effects of long-term (14-120 months) hCG-treatment of 17 male patients affected by isolated hypogonadotrophic hypogonadism (IHH) on testicular volume, plasma testosterone levels, and sperm concentration were assessed.
Report a problemFND-0151698107

Studies that did not test the peptide alone6

In this study, hCG (human chorionic gonadotropin) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking hCG (human chorionic gonadotropin).

14HumanNot a test of hCG (human chorionic gonadotropin) aloneNon-randomized trialEfficacy outcome
Among sperm-positive men attempting conception after hCG with possible added hMG, seven of 10 succeeded, including two from the small testis subset.
In plain wordsAmong sperm-positive men attempting conception after hCG with possible added hMG, seven of 10 succeeded.
Peptide
hCG (human chorionic gonadotropin)
Outcome
Not applicablePartner conception
Study
n = 10
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Measurements
Patients whose partner conceived
7 patients
sperm-positive men attempting conception, of 10
Successful patients from the small testis subset
2 patients
sperm-positive men attempting conception
Source sentences
Summary
Among sperm-positive patients attempting conception, seven out of 10 succeeded, two of whom were from the STS group.
1 context sentence(design, population, supporting numbers)
Summary · context
The effects of long-term (14-120 months) hCG-treatment of 17 male patients affected by isolated hypogonadotrophic hypogonadism (IHH) on testicular volume, plasma testosterone levels, and sperm concentration were assessed.
In this study, hCG (human chorionic gonadotropin) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking hCG (human chorionic gonadotropin).
Report a problemFND-0151698119
15HumanNot a test of hCG (human chorionic gonadotropin) aloneNon-randomized trialEfficacy outcome
In men previously receiving hCG alone, added hMG increased testicular volume in two patients.
In plain wordsIn men previously receiving hCG alone, adding hMG increased testicular volume in two patients.
Peptide
hCG (human chorionic gonadotropin)
Outcome
IncreaseIndividual testicular volume increase after hMG
Study
n = 8
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Measurements
Patients with increased testicular volume after hMG
2 patients
hMG added to hCG, of 8 patients
Source sentences
Summary
The administration of hMG to eight of these patients caused an increase in testicular volume in two patients but the mean volume was not statistically different from that recorded at the end of treatment with hCG alone.
1 context sentence(design, population, supporting numbers)
Summary · context
The effects of long-term (14-120 months) hCG-treatment of 17 male patients affected by isolated hypogonadotrophic hypogonadism (IHH) on testicular volume, plasma testosterone levels, and sperm concentration were assessed.
In this study, hCG (human chorionic gonadotropin) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking hCG (human chorionic gonadotropin).
Report a problemFND-0151698114
16HumanNot a test of hCG (human chorionic gonadotropin) aloneNon-randomized trialEfficacy outcome
In men with hypogonadotrophic hypogonadism, mean testicular volume with added hMG did not differ significantly from that after hCG alone.
In plain wordsIn men with hypogonadotrophic hypogonadism, mean testicular volume did not differ significantly with added hMG compared with hCG alone.
Peptide
hCG (human chorionic gonadotropin)
Outcome
No significant changeMean testicular volume after hMG
Study
n = 8
Comparator
End of hCG-alone treatment
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Source sentences
Summary
The administration of hMG to eight of these patients caused an increase in testicular volume in two patients but the mean volume was not statistically different from that recorded at the end of treatment with hCG alone.
1 context sentence(design, population, supporting numbers)
Summary · context
The effects of long-term (14-120 months) hCG-treatment of 17 male patients affected by isolated hypogonadotrophic hypogonadism (IHH) on testicular volume, plasma testosterone levels, and sperm concentration were assessed.
In this study, hCG (human chorionic gonadotropin) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking hCG (human chorionic gonadotropin).
Report a problemFND-0151698115
17HumanNot a test of hCG (human chorionic gonadotropin) aloneNon-randomized trialEfficacy outcome
In men previously receiving hCG alone, added hMG improved sperm concentration in three patients.
In plain wordsIn men previously receiving hCG alone, adding hMG improved sperm concentration in three patients.
Peptide
hCG (human chorionic gonadotropin)
Outcome
IncreaseIndividual sperm concentration improvement after hMG
Study
n = 8
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Measurements
Patients with improved sperm concentration after hMG
3 patients
hMG added to hCG, of 8 patients
Source sentences
Summary
Similarly, sperm concentration improved in three patients but again it did not differ significantly from that achieved in the course of hCG treatment.
2 context sentences(design, population, supporting numbers)
Summary · context
The administration of hMG to eight of these patients caused an increase in testicular volume in two patients but the mean volume was not statistically different from that recorded at the end of treatment with hCG alone.
Summary · context
The effects of long-term (14-120 months) hCG-treatment of 17 male patients affected by isolated hypogonadotrophic hypogonadism (IHH) on testicular volume, plasma testosterone levels, and sperm concentration were assessed.
In this study, hCG (human chorionic gonadotropin) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking hCG (human chorionic gonadotropin).
Report a problemFND-0151698116
18HumanNot a test of hCG (human chorionic gonadotropin) aloneNon-randomized trialEfficacy outcome
In men with hypogonadotrophic hypogonadism, sperm concentration with added hMG did not differ significantly from that achieved with hCG alone.
In plain wordsIn men with hypogonadotrophic hypogonadism, sperm concentration did not differ significantly with added hMG compared with hCG alone.
Peptide
hCG (human chorionic gonadotropin)
Outcome
No significant changeOverall sperm concentration after hMG
Study
n = 8
Comparator
hCG-alone treatment
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Source sentences
Summary
Similarly, sperm concentration improved in three patients but again it did not differ significantly from that achieved in the course of hCG treatment.
1 context sentence(design, population, supporting numbers)
Summary · context
The effects of long-term (14-120 months) hCG-treatment of 17 male patients affected by isolated hypogonadotrophic hypogonadism (IHH) on testicular volume, plasma testosterone levels, and sperm concentration were assessed.
In this study, hCG (human chorionic gonadotropin) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking hCG (human chorionic gonadotropin).
Report a problemFND-0151698117
19HumanNot a test of hCG (human chorionic gonadotropin) aloneNon-randomized trialEfficacy outcome
In men previously receiving hCG alone, one patient became sperm-positive after hMG was added.
In plain wordsIn men previously receiving hCG alone, one patient became sperm-positive after hMG was added.
Peptide
hCG (human chorionic gonadotropin)
Outcome
IncreaseNew sperm-positive patient after hMG
Study
n = 8
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Measurements
Patients newly sperm-positive after hMG
1 patients
hMG added to hCG, of 8 patients
Source sentences
Summary
It is noteworthy that one patient became sperm-positive after the addition of hMG to his therapeutic regimen.
1 context sentence(design, population, supporting numbers)
Summary · context
The effects of long-term (14-120 months) hCG-treatment of 17 male patients affected by isolated hypogonadotrophic hypogonadism (IHH) on testicular volume, plasma testosterone levels, and sperm concentration were assessed.
In this study, hCG (human chorionic gonadotropin) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking hCG (human chorionic gonadotropin).
Report a problemFND-0151698118

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
14 Oct 2026, 05:02 UTC
Study results updated
Version 1
14 Oct 2026, 01:46 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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Journal Article

MeSH terms

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