Biosynthetic human growth hormone preserves both muscle protein synthesis and the decrease in muscle-free glutamine, and improves whole-body nitrogen economy after operation.

Hammarqvist F, Strömberg C, von der Decken A, Vinnars E, Wernerman J

Annals of surgery1 Aug 1992Cited by 71 (Europe PMC)

PMID1503519DOI10.1097/00000658-199208000-00009PepBankPUB-01503519

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. 4 results from people.

01HumanRandomized controlled trialEfficacy outcome
In cholecystectomy patients, hGH impeded the postoperative decrease in total muscle ribosome concentration seen in controls.
In plain wordsAfter gallbladder surgery, hGH limited the decrease in muscle ribosomes compared with placebo.
Peptide
HGH (somatotropin)
Outcome
IncreaseTotal ribosome concentration
Study
n = 17
Comparator
Placebo
Outcome group
Protein and amino acid metabolism · Musculoskeletal
Studied dose
0.3 U/kg/24 hours · 3 postoperative daysAs given in this study (human).
Measurements
Total ribosome concentration decrease
15.3%
control group
Source sentences
Summary
The significant postoperative decrease in the total ribosome concentration (15.3 +/- 6.4%) and the polyribosome concentration (20.9 +/- 6.5%) in the control group was impeded in the group receiving synthetic hGH.
1 context sentence(design, population, supporting numbers)
Summary · context
As a reproducible human trauma model, patients (n = 17) undergoing elective cholecystectomy were studied for 3 postoperative days. They were randomly allocated to receive either recombinant human growth hormone (hGH; 0.3 U/kg/24 hours) or placebo together with total parenteral nutrition, including 0…
Report a problemFND-0150351901
02HumanRandomized controlled trialEfficacy outcome
In cholecystectomy patients, hGH impeded the postoperative decrease in muscle polyribosome concentration seen in controls.
In plain wordsAfter gallbladder surgery, hGH limited the decrease in muscle polyribosomes compared with placebo.
Peptide
HGH (somatotropin)
Outcome
IncreasePolyribosome concentration
Study
n = 17
Comparator
Placebo
Outcome group
Protein and amino acid metabolism · Musculoskeletal
Studied dose
0.3 U/kg/24 hours · 3 postoperative daysAs given in this study (human).
Measurements
Polyribosome concentration decrease
20.9%
control group
Source sentences
Summary
The significant postoperative decrease in the total ribosome concentration (15.3 +/- 6.4%) and the polyribosome concentration (20.9 +/- 6.5%) in the control group was impeded in the group receiving synthetic hGH.
1 context sentence(design, population, supporting numbers)
Summary · context
As a reproducible human trauma model, patients (n = 17) undergoing elective cholecystectomy were studied for 3 postoperative days. They were randomly allocated to receive either recombinant human growth hormone (hGH; 0.3 U/kg/24 hours) or placebo together with total parenteral nutrition, including 0…
Report a problemFND-0150351902
03HumanRandomized controlled trialEfficacy outcome
In cholecystectomy patients, muscle free glutamine decreased less with hGH than in controls.
In plain wordsAfter gallbladder surgery, muscle glutamine decreased less with hGH than with placebo.
Peptide
HGH (somatotropin)
Outcome
IncreaseMuscle free glutamine
Study
n = 17
Comparator
Placebo
Outcome group
Protein and amino acid metabolism · Musculoskeletal
Studied dose
0.3 U/kg/24 hours · 3 postoperative daysAs given in this study (human).
Measurements
Muscle free glutamine decrease
35.6%
control group
Source sentences
Summary
Muscle free glutamine decreased by 35.6 +/- 4.2% in the control group and to a lesser extent in the group that was given hGH after operation (p less than 0.05).
1 context sentence(design, population, supporting numbers)
Summary · context
As a reproducible human trauma model, patients (n = 17) undergoing elective cholecystectomy were studied for 3 postoperative days. They were randomly allocated to receive either recombinant human growth hormone (hGH; 0.3 U/kg/24 hours) or placebo together with total parenteral nutrition, including 0…
Report a problemFND-0150351903
04HumanRandomized controlled trialEfficacy outcome
In cholecystectomy patients, cumulative nitrogen balance was not different from zero with hGH but was negative in controls.
In plain wordsAfter gallbladder surgery, nitrogen balance was near zero with hGH and negative with placebo.
Peptide
HGH (somatotropin)
Outcome
IncreaseCumulative nitrogen balance
Study
n = 17
Comparator
Placebo
Outcome group
Protein and amino acid metabolism · Metabolic and weight
Studied dose
0.3 U/kg/24 hours · 3 postoperative daysAs given in this study (human).
Measurements
Nitrogen balance
−2.32 gN
hGH
Nitrogen balance
−7.09 gN
control
Source sentences
Summary
The cumulated nitrogen balance for the study period was negative in the control group (-7.09 +/- 0.71 gN), but was not different from zero in the hGH group (-2.32 +/- 1.66 gN).
1 context sentence(design, population, supporting numbers)
Summary · context
As a reproducible human trauma model, patients (n = 17) undergoing elective cholecystectomy were studied for 3 postoperative days. They were randomly allocated to receive either recombinant human growth hormone (hGH; 0.3 U/kg/24 hours) or placebo together with total parenteral nutrition, including 0…
Report a problemFND-0150351904

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
28 Oct 2026, 02:03 UTC
Study results updated
Version 1
27 Oct 2026, 16:37 UTC
First added · source update from Europe PMC

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