The effect of clomiphene citrate and its Zu or En isomers on the reproductive system of the immature male rat.

Weissenberg R, Dar Y, Lunenfeld B

Andrologia1 May 1992Cited by 4 (Europe PMC)

PMID1503253DOI10.1111/j.1439-0272.1992.tb02631.xPepBankPUB-01503253

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study9

6 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In intact immature male rats, enclomiphene inhibited testis weight increase.
In plain wordsIn immature male rats, enclomiphene reduced testis weight gain.
Peptide
Enclomiphene
Outcome
DecreaseTestis weight increase
Study
ratn: not reported in source
immature male rats
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
Dose not stated
Source sentences
Summary
This led to inhibition of weight increase of testis and accessory glands in the intact group.
2 context sentences(design, population, supporting numbers)
Summary · context
The effect of clomiphene citrate (CC) and of its Zuclomiphene (ZuC) and Enclomiphene (EnC) isomers on the reproductive organs of immature male rats under different experimental conditions is reported.
Summary · context
CC, ZuC, and EnC were administered daily to groups of either intact or castrated rats between the age of 21-44 d.
Report a problemFND-0150325301
02AnimalAnimal study (in vivo)Efficacy outcome
In intact immature male rats, enclomiphene inhibited accessory gland weight increase.
In plain wordsIn immature male rats, enclomiphene reduced accessory gland weight gain.
Peptide
Enclomiphene
Outcome
DecreaseAccessory gland weight increase
Study
ratn: not reported in source
immature male rats
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
Dose not stated
Source sentences
Summary
This led to inhibition of weight increase of testis and accessory glands in the intact group.
2 context sentences(design, population, supporting numbers)
Summary · context
The effect of clomiphene citrate (CC) and of its Zuclomiphene (ZuC) and Enclomiphene (EnC) isomers on the reproductive organs of immature male rats under different experimental conditions is reported.
Summary · context
CC, ZuC, and EnC were administered daily to groups of either intact or castrated rats between the age of 21-44 d.
Report a problemFND-0150325302
03AnimalAnimal study (in vivo)Efficacy outcome
In immature male rats, enclomiphene arrested spermatogenesis at the young spermatid stage.
In plain wordsIn immature male rats, enclomiphene stopped sperm development at the young spermatid stage.
Peptide
Enclomiphene
Outcome
DecreaseSpermatogenesis arrest
Study
ratn: not reported in source
immature male rats
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
Dose not stated
Source sentences
Summary
Spermatogenesis was arrested at the stage of primary spermatocyte following CC and ZuC treatment, and at the stage of young spermatids by EnC treatment.
2 context sentences(design, population, supporting numbers)
Summary · context
The effect of clomiphene citrate (CC) and of its Zuclomiphene (ZuC) and Enclomiphene (EnC) isomers on the reproductive organs of immature male rats under different experimental conditions is reported.
Summary · context
CC, ZuC, and EnC were administered daily to groups of either intact or castrated rats between the age of 21-44 d.
Report a problemFND-0150325303
04AnimalAnimal study (in vivo)Efficacy outcome
In castrated immature rats, enclomiphene increased seminal vesicle weight versus castrated controls, but weight remained below normal controls.
In plain wordsIn castrated immature rats, enclomiphene increased seminal vesicle weight versus castrated controls, but weight remained below normal controls.
Peptide
Enclomiphene
Outcome
IncreaseSeminal vesicle weight increase
Study
ratn: not reported in source
immature male rats
Comparator
castrated controls
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
Dose not stated
Source sentences
Summary
In the castrated group clomiphenes significantly stimulated weight increase of seminal vesicles (SV) compared with castrated control animals, but the former group were unable to achieve organ weight gain comparable to that in normal controls.
2 context sentences(design, population, supporting numbers)
Summary · context
The effect of clomiphene citrate (CC) and of its Zuclomiphene (ZuC) and Enclomiphene (EnC) isomers on the reproductive organs of immature male rats under different experimental conditions is reported.
Summary · context
CC, ZuC, and EnC were administered daily to groups of either intact or castrated rats between the age of 21-44 d.
Report a problemFND-0150325304
05AnimalAnimal study (in vivo)Efficacy outcome
In intact immature rats, enclomiphene suppressed LH secretion.
In plain wordsIn immature rats, enclomiphene reduced LH secretion.
Peptide
Enclomiphene
Outcome
DecreaseLH secretion
Study
ratn: not reported in source
immature male rats
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
Dose not stated
Source sentences
Summary
In intact treated rats LH and testosterone secretion were suppressed by all forms of clomiphenes.
2 context sentences(design, population, supporting numbers)
Summary · context
The effect of clomiphene citrate (CC) and of its Zuclomiphene (ZuC) and Enclomiphene (EnC) isomers on the reproductive organs of immature male rats under different experimental conditions is reported.
Summary · context
CC, ZuC, and EnC were administered daily to groups of either intact or castrated rats between the age of 21-44 d.
Report a problemFND-0150325308
06AnimalAnimal study (in vivo)Efficacy outcome
In intact immature rats, enclomiphene suppressed testosterone secretion.
In plain wordsIn immature rats, enclomiphene reduced testosterone secretion.
Peptide
Enclomiphene
Outcome
DecreaseTestosterone secretion
Study
ratn: not reported in source
immature male rats
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
Dose not stated
Source sentences
Summary
In intact treated rats LH and testosterone secretion were suppressed by all forms of clomiphenes.
2 context sentences(design, population, supporting numbers)
Summary · context
The effect of clomiphene citrate (CC) and of its Zuclomiphene (ZuC) and Enclomiphene (EnC) isomers on the reproductive organs of immature male rats under different experimental conditions is reported.
Summary · context
CC, ZuC, and EnC were administered daily to groups of either intact or castrated rats between the age of 21-44 d.
Report a problemFND-0150325309

Studies that did not test the peptide alone3

In this study, Enclomiphene was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Enclomiphene.

07AnimalNot a test of Enclomiphene aloneAnimal study (in vivo)Efficacy outcome
In intact immature rats, hCG with enclomiphene abolished the drug effect on spermatogenesis.
In plain wordsIn immature rats, hCG with enclomiphene removed the drug effect on sperm development.
Peptide
Enclomiphene
Outcome
Direction not reportedSpermatogenesis under hCG coadministration
Study
ratn: not reported in source
immature male rats
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Source sentences
Summary
Administration of human Chorionic Gonadotropin (hCG) together with CC or each of its isomers to intact animals, abolished the drug effect on spermatogenesis and on reproductive organ growth.
2 context sentences(design, population, supporting numbers)
Summary · context
The effect of clomiphene citrate (CC) and of its Zuclomiphene (ZuC) and Enclomiphene (EnC) isomers on the reproductive organs of immature male rats under different experimental conditions is reported.
Summary · context
CC, ZuC, and EnC were administered daily to groups of either intact or castrated rats between the age of 21-44 d.
In this study, Enclomiphene was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Enclomiphene.
Report a problemFND-0150325305
08AnimalNot a test of Enclomiphene aloneAnimal study (in vivo)Efficacy outcome
In intact immature rats, hCG with enclomiphene abolished the drug effect on reproductive organ growth.
In plain wordsIn immature rats, hCG with enclomiphene removed the drug effect on reproductive organ growth.
Peptide
Enclomiphene
Outcome
Direction not reportedReproductive organ growth under hCG coadministration
Study
ratn: not reported in source
immature male rats
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Source sentences
Summary
Administration of human Chorionic Gonadotropin (hCG) together with CC or each of its isomers to intact animals, abolished the drug effect on spermatogenesis and on reproductive organ growth.
2 context sentences(design, population, supporting numbers)
Summary · context
The effect of clomiphene citrate (CC) and of its Zuclomiphene (ZuC) and Enclomiphene (EnC) isomers on the reproductive organs of immature male rats under different experimental conditions is reported.
Summary · context
CC, ZuC, and EnC were administered daily to groups of either intact or castrated rats between the age of 21-44 d.
In this study, Enclomiphene was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Enclomiphene.
Report a problemFND-0150325306
09AnimalNot a test of Enclomiphene aloneAnimal study (in vivo)Efficacy outcome
In castrated immature rats, testosterone with enclomiphene abolished the drug effect on accessory gland growth inhibition.
In plain wordsIn castrated immature rats, testosterone with enclomiphene removed the drug effect on accessory gland growth inhibition.
Peptide
Enclomiphene
Outcome
Direction not reportedAccessory gland growth under testosterone coadministration
Study
ratn: not reported in source
immature male rats
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Source sentences
Summary
Administration of CC, ZuC, and EnC together with testosterone to castrated animals, abolished the drug effect on growth inhibition of accessory glands.
2 context sentences(design, population, supporting numbers)
Summary · context
The effect of clomiphene citrate (CC) and of its Zuclomiphene (ZuC) and Enclomiphene (EnC) isomers on the reproductive organs of immature male rats under different experimental conditions is reported.
Summary · context
CC, ZuC, and EnC were administered daily to groups of either intact or castrated rats between the age of 21-44 d.
In this study, Enclomiphene was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Enclomiphene.
Report a problemFND-0150325307

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
21 Oct 2026, 15:58 UTC
Study results updated
Version 1
21 Oct 2026, 12:50 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

Journal Article

MeSH terms

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