Skip to content

Study · Measured the body's own peptide · 1992

2 results

Interleukin 1 regulates secretion of zinc-thymulin by human thymic epithelial cells and its action on T-lymphocyte proliferation and nuclear protein kinase C.

Coto JA, Hadden EM, Sauro M, Zorn N, Hadden JW

Proceedings of the National Academy of Sciences of the United States of America1 Aug 1992Cited by 49 (Europe PMC)

PMID1502195 (opens in a new tab)PMCIDPMC49789 (opens in a new tab)DOI10.1073/pnas.89.16.7752 (opens in a new tab)PepBankPUB-01502195
Source linkPubMedAsk about this study
Jump to 2 results

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

No result from this study comes from a test of the peptide.

Natural levels measured1

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

  1. 01LabEndogenous levelIn vitro (cells)Mechanism

    In human thymic epithelial cells, IL-1 stimulated thymulin secretion as assessed by lymphocyte induction and the rosette assay.

    In plain wordsIn cells, IL-1 increased secretion of the body's own thymulin.

    Peptide
    Thymulin (serum thymic factor)
    Outcome
    IncreaseThymulin secretion
    Study

    humann: not reported in source

    Human thymic epithelial cells and peripheral blood lymphocytes
    Outcome group
    Immune response · Immune and inflammation

    Source sentences

    Summary
    IL-1 was shown to stimulate the secretion of thymulin as measured both by its ability to stimulate induction of IL-2 receptor-positive lymphocytes from human peripheral blood lymphocytes and by the azathioprine-sensitive rosette assay.

    This result measures the body's own Thymulin (serum thymic factor). Nobody was given the peptide. It is not evidence about taking it.

Studies that did not test the peptide alone1

In this study, Thymulin (serum thymic factor) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Thymulin (serum thymic factor).

  1. 02LabNot a test of Thymulin (serum thymic factor) aloneIn vitro (cell-free)Mechanism

    In isolated lymphocyte nuclei, zinc-thymulin with IL-1 stimulated nuclear protein kinase C, whereas zinc-thymulin without IL-1 did not.

    In plain wordsIn lab tests, zinc-thymulin with IL-1 stimulated nuclear protein kinase C, whereas zinc-thymulin without IL-1 did not.

    Peptide
    Thymulin (serum thymic factor)
    Outcome
    IncreaseNuclear protein kinase C stimulation
    Study

    humann: not reported in source

    Isolated lymphocyte nuclei
    Outcome group
    Receptor activity and mechanism · Immune and inflammation

    Source sentences

    Summary
    In addition, the zinc-thymulin complex in the presence, but not absence, of IL-1 stimulates nuclear protein kinase C in isolated lymphocyte nuclei.

    In this study, Thymulin (serum thymic factor) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymulin (serum thymic factor).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

PepBank is a research reference. Talk to a doctor before you use any peptide.