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Study · Randomized controlled trial · n = 12 · 1992

4 results

Oxytocin in obsessive compulsive disorder.

den Boer JA, Westenberg HG

Peptides1 Nov 1992Cited by 49 (Europe PMC)

PMID1494489 (opens in a new tab)DOI10.1016/0196-9781(92)90010-z (opens in a new tab)PepBankPUB-01494489
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. 4 results from people.

  1. 01HumanRandomized controlled trialEfficacy outcome

    In patients with obsessive compulsive disorder, the number of obsessions was not reduced in either the intranasal oxytocin (18 IU per day) group or the placebo group.

    In plain wordsIn people with obsessive compulsive disorder, obsessions did not fall with oxytocin nasal spray or with placebo.

    Peptide
    Oxytocin
    Outcome
    No significant changeNumber of obsessions
    Study

    n = 12

    Comparator
    Placebo
    Outcome group
    Anxiety and mood · Mental health and mood
    Studied dose
    18 IU per day · intranasalAs given in this study (human).

    Source sentences

    Summary
    No reductions in the number of obsessions or compulsive behaviors were observed in either treatment group.
    2 context sentences
    Summary · context
    A double-blind, placebo-controlled study with syntocinon (oxytocin) was carried out in 12 patients, nine females and three males with obsessive compulsive disorder (OCD).
    Summary · context
    Patients were treated by intranasal administration of oxytocin spray (18 IU per day) or placebo.
  2. 02HumanRandomized controlled trialEfficacy outcome

    In patients with obsessive compulsive disorder, the number of compulsive behaviors was not reduced in either the intranasal oxytocin (18 IU per day) group or the placebo group.

    In plain wordsIn people with obsessive compulsive disorder, compulsive behaviors did not fall with oxytocin nasal spray or with placebo.

    Peptide
    Oxytocin
    Outcome
    No significant changeNumber of compulsive behaviors
    Study

    n = 12

    Comparator
    Placebo
    Outcome group
    Anxiety and mood · Mental health and mood
    Studied dose
    18 IU per day · intranasalAs given in this study (human).

    Source sentences

    Summary
    No reductions in the number of obsessions or compulsive behaviors were observed in either treatment group.
    2 context sentences
    Summary · context
    A double-blind, placebo-controlled study with syntocinon (oxytocin) was carried out in 12 patients, nine females and three males with obsessive compulsive disorder (OCD).
    Summary · context
    Patients were treated by intranasal administration of oxytocin spray (18 IU per day) or placebo.
  3. 03HumanCase report or seriesEfficacy outcome

    In one open-label patient with obsessive compulsive disorder given a threefold higher oxytocin dose, checking rituals fell slightly.

    In plain wordsIn one person with obsessive compulsive disorder given a higher oxytocin dose without placebo, checking rituals fell slightly.

    Peptide
    Oxytocin
    Outcome
    DecreaseChecking rituals at a threefold higher dose (patient 1)
    Study

    n = 1

    Outcome group
    Anxiety and mood · Mental health and mood
    Studied dose
    threefold higher than 18 IU per dayAs given in this study (human).

    Source sentences

    Summary
    In one patient a slight reduction in the number of checking rituals was observed, whereas in the other patient virtually no effect was observed.
    1 context sentence
    Summary · context
    To evaluate whether a higher dosage would exert more beneficial effects, two additional patients were treated with a threefold higher dosage of oxytocin using an open design.
  4. 04HumanCase report or seriesEfficacy outcome

    In a second open-label patient with obsessive compulsive disorder given a threefold higher oxytocin dose, virtually no effect was observed.

    In plain wordsIn a second person with obsessive compulsive disorder given a higher oxytocin dose without placebo, there was almost no effect.

    Peptide
    Oxytocin
    Outcome
    No significant changeChecking rituals at a threefold higher dose (patient 2)
    Study

    n = 1

    Outcome group
    Anxiety and mood · Mental health and mood
    Studied dose
    threefold higher than 18 IU per dayAs given in this study (human).

    Source sentences

    Summary
    In one patient a slight reduction in the number of checking rituals was observed, whereas in the other patient virtually no effect was observed.
    1 context sentence
    Summary · context
    To evaluate whether a higher dosage would exert more beneficial effects, two additional patients were treated with a threefold higher dosage of oxytocin using an open design.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 20:03 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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