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Study · Ex vivo tissue · 1992

9 results

Thymosin alpha-1 enhances the fertilizing capacity of human sperm cell: implication in diagnosis and treatment of male infertility.

Naz RK, Kaplan P, Goldstein AL

Biology of reproduction1 Dec 1992Cited by 19 (Europe PMC)

PMID1493170 (opens in a new tab)DOI10.1095/biolreprod47.6.1064 (opens in a new tab)PepBankPUB-01493170
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study9

5 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabEx vivo tissueEfficacy outcome

    In human sperm cells, thymosin alpha‑1, but not thymosin beta 4, significantly increased sperm penetration rates in the sperm penetration assay.

    In plain wordsIn lab tests on human sperm, thymosin alpha‑1 increased sperm penetration rates in the sperm penetration assay, while thymosin beta 4 did not.

    Peptide
    Thymosin alpha-1
    Outcome
    IncreaseSperm penetration rate in sperm penetration assay
    Study

    humann: not reported in source

    human sperm cells
    Comparator
    Thymosin beta 4
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    T alpha 1, but not the T beta 4, significantly (p < 0.001) increased the human sperm penetration rates in sperm penetration assay (SPA).
    1 context sentence
    Summary · context
    The effects of synthetic thymosin peptides (T alpha 1 and T beta 4) and their antibodies on the fertilizing capacity of human sperm cells were investigated.
  2. 02LabEx vivo tissueMechanism

    In human sperm cells, thymosin alpha‑1 enhanced spontaneous and calcium ionophore-induced acrosome reaction.

    In plain wordsIn lab tests on human sperm, thymosin alpha‑1 increased the acrosome reaction, a step needed for fertilization.

    Peptide
    Thymosin alpha-1
    Outcome
    IncreaseAcrosome reaction
    Study

    humann: not reported in source

    human sperm cells
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The T alpha 1 and antibodies to both T alpha 1 and T beta 4 enhanced spontaneous as well as calcium ionophore-induced acrosome reaction and release of acrosin from the human sperm cells.
    1 context sentence
    Summary · context
    The effects of synthetic thymosin peptides (T alpha 1 and T beta 4) and their antibodies on the fertilizing capacity of human sperm cells were investigated.
  3. 03LabEx vivo tissueMechanism

    In human sperm cells, thymosin alpha‑1 enhanced the release of acrosin.

    In plain wordsIn lab tests on human sperm, thymosin alpha‑1 increased the release of acrosin, an enzyme involved in fertilization.

    Peptide
    Thymosin alpha-1
    Outcome
    IncreaseAcrosin release
    Study

    humann: not reported in source

    human sperm cells
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The T alpha 1 and antibodies to both T alpha 1 and T beta 4 enhanced spontaneous as well as calcium ionophore-induced acrosome reaction and release of acrosin from the human sperm cells.
    1 context sentence
    Summary · context
    The effects of synthetic thymosin peptides (T alpha 1 and T beta 4) and their antibodies on the fertilizing capacity of human sperm cells were investigated.
  4. 04LabEx vivo tissueEfficacy outcome

    In human sperm cells, thymosin alpha‑1 had no effect on percent sperm motility.

    In plain wordsIn lab tests on human sperm, thymosin alpha‑1 did not change the percentage of moving sperm.

    Peptide
    Thymosin alpha-1
    Outcome
    No significant changePercent sperm motility
    Study

    humann: not reported in source

    human sperm cells
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    There was no effect of T alpha 1 and antibodies to T alpha 1 and T beta 4 on percent sperm motility
    1 context sentence
    Summary · context
    The effects of synthetic thymosin peptides (T alpha 1 and T beta 4) and their antibodies on the fertilizing capacity of human sperm cells were investigated.
  5. 05LabEx vivo tissueEfficacy outcome

    In human sperm cells, thymosin alpha‑1 significantly affected motility characteristics such as velocity, amplitude of lateral head displacement and beta frequency; direction not stated.

    In plain wordsIn lab tests on human sperm, thymosin alpha‑1 changed how sperm moved, including speed; the abstract gives no direction.

    Peptide
    Thymosin alpha-1
    Outcome
    Direction not reportedSperm motility characteristics (velocity, ALH, beta frequency)
    Study

    humann: not reported in source

    human sperm cells
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    although they significantly affected various motility characteristics such as velocity, amplitude of lateral head displacement (ALH), and beta frequency--the motility parameters involved in hyperactivation phenomenon of sperm cells.
    1 context sentence
    Summary · context
    The effects of synthetic thymosin peptides (T alpha 1 and T beta 4) and their antibodies on the fertilizing capacity of human sperm cells were investigated.

Natural levels measured1

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

  1. 06HumanEndogenous levelObservational studyOther

    Seminal plasma thymosin alpha‑1 levels were significantly lower in infertile men with defective sperm function than in fertile men.

    In plain wordsThe body's own thymosin alpha‑1 level in semen was lower in infertile men with defective sperm function.

    Peptide
    Thymosin alpha-1
    Outcome
    DecreaseSeminal plasma thymosin alpha 1 in infertile men
    Study

    n: not reported in source

    human seminal plasma
    Comparator
    Fertile men
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health

    Source sentences

    Summary
    Both T alpha 1 and T beta 4 were detected in the seminal plasma of fertile men, and the levels of T alpha 1 were significantly (p = 0.002) lower in the seminal plasma of infertile men having defective sperm function.

    This result measures the body's own Thymosin alpha-1. Nobody was given the peptide. It is not evidence about taking it.

Studies that did not test the peptide alone3

In this study, Thymosin alpha-1 was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Thymosin alpha-1.

  1. 07LabNot a test of Thymosin alpha-1 aloneEx vivo tissueMechanism

    In human sperm cells, antibodies to thymosin alpha‑1 and thymosin beta 4 significantly increased sperm penetration rates, by up to 4.7-fold.

    In plain wordsIn lab tests on human sperm, antibodies against thymosin alpha‑1 and beta 4 increased sperm penetration rates.

    Peptide
    Thymosin alpha-1
    Outcome
    IncreaseSperm penetration rate with antibodies to thymosin alpha 1 and beta 4
    Study

    humann: not reported in source

    human sperm cells
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health

    Source sentences

    Summary
    Antibodies to both T alpha 1 and TB4, which predominantly bound to the acrosomal region of human sperm cell in the indirect immunofluorescence technique (IFT), also significantly (p < 0.001) increased (up to 4.7-fold) the human sperm penetration rates in SPA.
    1 context sentence
    Summary · context
    The effects of synthetic thymosin peptides (T alpha 1 and T beta 4) and their antibodies on the fertilizing capacity of human sperm cells were investigated.

    In this study, Thymosin alpha-1 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin alpha-1.

  2. 08LabNot a test of Thymosin alpha-1 aloneEx vivo tissueMechanism

    In human sperm cells, antibodies to thymosin alpha‑1 and thymosin beta 4 enhanced spontaneous and calcium ionophore-induced acrosome reaction and the release of acrosin.

    In plain wordsIn lab tests on human sperm, antibodies against thymosin alpha‑1 and beta 4 increased the acrosome reaction and acrosin release.

    Peptide
    Thymosin alpha-1
    Outcome
    IncreaseAcrosome reaction and acrosin release with antibodies to thymosin alpha 1 and beta 4
    Study

    humann: not reported in source

    human sperm cells
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health

    Source sentences

    Summary
    The T alpha 1 and antibodies to both T alpha 1 and T beta 4 enhanced spontaneous as well as calcium ionophore-induced acrosome reaction and release of acrosin from the human sperm cells.

    In this study, Thymosin alpha-1 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin alpha-1.

  3. 09LabNot a test of Thymosin alpha-1 aloneEx vivo tissueMechanism

    In human sperm cells, antibodies to thymosin alpha‑1 and thymosin beta 4 had no effect on percent sperm motility.

    In plain wordsIn lab tests on human sperm, antibodies against thymosin alpha‑1 and beta 4 did not change the percentage of moving sperm.

    Peptide
    Thymosin alpha-1
    Outcome
    No significant changeSperm motility with antibodies to thymosin alpha 1 and beta 4
    Study

    humann: not reported in source

    human sperm cells
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health

    Source sentences

    Summary
    There was no effect of T alpha 1 and antibodies to T alpha 1 and T beta 4 on percent sperm motility, although they significantly affected various motility characteristics such as velocity, amplitude of lateral head displacement (ALH), and beta frequency--the motility parameters involved in hyperacti…

    In this study, Thymosin alpha-1 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin alpha-1.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    10 Oct 2026, 08:55 UTC

    Study results updated

  2. Version 2

    9 Oct 2026, 03:03 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    9 Oct 2026, 03:02 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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