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Study · Randomized controlled trial · n = 20 · 1992

8 results

Effects of recombinant human growth hormone in patients with severe sepsis.

Voerman HJ, van Schijndel RJ, Groeneveld AB, de Boer H, Nauta JP, van der Veen EA, Thijs LG

Annals of surgery1 Dec 1992Cited by 90 (Europe PMC)

PMID1466618 (opens in a new tab)DOI10.1097/00000658-199212000-00006 (opens in a new tab)PepBankPUB-01466618
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study8

8 results from studies that gave the peptide. 8 results from people.

  1. 01HumanRandomized controlled trialEfficacy outcome

    In patients with severe sepsis, GH decreased nitrogen production while production increased in controls.

    In plain wordsIn patients with severe sepsis, GH lowered nitrogen production compared with placebo.

    Peptide
    HGH (somatotropin)
    Outcome
    DecreaseNitrogen production
    Study

    n = 20

    Comparator
    Placebo
    Outcome group
    Protein and amino acid metabolism · Metabolic and weight
    Studied dose
    0.1 mg/kg/day · continuous intravenous infusion · second, third, and fourth days after admissionAs given in this study (human).

    Source sentences

    Summary
    During GH administration, nitrogen production decreased significantly in the GH group and increased in controls (p < 0.01).
    3 context sentences
    Summary · context
    It was designed as a prospective, randomized, placebo-controlled trial, and performed in the medical intensive care unit of a university hospital.
    Summary · context
    Twenty patients admitted with septic shock and receiving standard parenteral nutrition served as subjects.
    Summary · context
    Treatment consisted of GH 0.1 mg/kg/day or placebo administered as continuous intravenous infusion on the second, third, and fourth days after admission.
  2. 02HumanRandomized controlled trialEfficacy outcome

    In patients with severe sepsis, nitrogen balance became slightly positive during GH treatment compared with negative balance in controls.

    In plain wordsIn patients with severe sepsis, GH improved nitrogen balance compared with placebo.

    Peptide
    HGH (somatotropin)
    Outcome
    IncreaseNitrogen balance
    Study

    n = 20

    Comparator
    Placebo
    Outcome group
    Protein and amino acid metabolism · Metabolic and weight
    Studied dose
    0.1 mg/kg/day · continuous intravenous infusion · second, third, and fourth days after admissionAs given in this study (human).

    Measurements

    Nitrogen balance
    1.2 g/day
    GH day 3
    Nitrogen balance
    −3.7 g/day
    controls day 3

    Source sentences

    Summary
    Nitrogen balance became slightly positive in the GH group during treatment: 1.2 +/- 6.4 versus controls -3.7 +/- 3.8 g/day (day 3) (p < 0.05).
    3 context sentences
    Summary · context
    It was designed as a prospective, randomized, placebo-controlled trial, and performed in the medical intensive care unit of a university hospital.
    Summary · context
    Twenty patients admitted with septic shock and receiving standard parenteral nutrition served as subjects.
    Summary · context
    Treatment consisted of GH 0.1 mg/kg/day or placebo administered as continuous intravenous infusion on the second, third, and fourth days after admission.
  3. 03HumanRandomized controlled trialEfficacy outcome

    In patients with severe sepsis, 3-methylhistidine excretion did not differ between GH and controls.

    In plain wordsIn patients with severe sepsis, GH did not change the muscle breakdown measure compared with placebo.

    Peptide
    HGH (somatotropin)
    Outcome
    No significant change3-Methylhistidine excretion
    Study

    n = 20

    Comparator
    Placebo
    Outcome group
    Protein and amino acid metabolism · Metabolic and weight
    Studied dose
    0.1 mg/kg/day · continuous intravenous infusion · second, third, and fourth days after admissionAs given in this study (human).

    Source sentences

    Summary
    3-Methylhistidine excretion as a measure of absolute muscle breakdown declined during the study period, but did not differ between groups.
    3 context sentences
    Summary · context
    It was designed as a prospective, randomized, placebo-controlled trial, and performed in the medical intensive care unit of a university hospital.
    Summary · context
    Twenty patients admitted with septic shock and receiving standard parenteral nutrition served as subjects.
    Summary · context
    Treatment consisted of GH 0.1 mg/kg/day or placebo administered as continuous intravenous infusion on the second, third, and fourth days after admission.
  4. 04HumanRandomized controlled trialEfficacy outcome

    In patients with severe sepsis, differences between GH and controls disappeared within 24 hours after treatment stopped.

    In plain wordsIn patients with severe sepsis, differences from placebo disappeared within 24 hours after GH stopped.

    Peptide
    HGH (somatotropin)
    Outcome
    No significant changePersistence of nitrogen effects
    Study

    n: not reported in source

    Comparator
    Placebo
    Outcome group
    Protein and amino acid metabolism · Metabolic and weight
    Studied dose
    0.1 mg/kg/day · continuous intravenous infusion · second, third, and fourth days after admissionAs given in this study (human).

    Source sentences

    Summary
    Within 24 hours after cessation of treatment, differences between GH and controls disappeared.
    3 context sentences
    Summary · context
    It was designed as a prospective, randomized, placebo-controlled trial, and performed in the medical intensive care unit of a university hospital.
    Summary · context
    Twenty patients admitted with septic shock and receiving standard parenteral nutrition served as subjects.
    Summary · context
    Treatment consisted of GH 0.1 mg/kg/day or placebo administered as continuous intravenous infusion on the second, third, and fourth days after admission.
  5. 05HumanNon-randomized trialEfficacy outcome

    In patients with severe sepsis, insulin, IGF-1, glycerol, free fatty acids, and beta-hydroxybutyrate increased during GH treatment.

    In plain wordsIn patients with severe sepsis, five hormone and metabolic markers increased during GH treatment.

    Peptide
    HGH (somatotropin)
    Outcome
    IncreaseInsulin, IGF-1, glycerol, free fatty acids, and beta-hydroxybutyrate
    Study

    n: not reported in source

    Outcome group
    Metabolic pathways and metabolomics · Metabolic and weight
    Studied dose
    0.1 mg/kg/day · continuous intravenous infusion · second, third, and fourth days after admissionAs given in this study (human).

    Source sentences

    Summary
    The levels of insulin, insulinlike growth factor 1, glycerol, free fatty acids, and beta-hydroxybutyrate increased during treatment.
    3 context sentences
    Summary · context
    It was designed as a prospective, randomized, placebo-controlled trial, and performed in the medical intensive care unit of a university hospital.
    Summary · context
    Twenty patients admitted with septic shock and receiving standard parenteral nutrition served as subjects.
    Summary · context
    Treatment consisted of GH 0.1 mg/kg/day or placebo administered as continuous intravenous infusion on the second, third, and fourth days after admission.
  6. 06HumanNon-randomized trialPharmacokinetics

    In patients with severe sepsis, GH levels declined over 3 treatment days despite continuous intravenous administration.

    In plain wordsIn patients with severe sepsis, GH levels declined during continuous infusion.

    Peptide
    HGH (somatotropin)
    Outcome
    DecreaseGH concentrations during infusion
    Study

    n: not reported in source

    Outcome group
    Pharmacokinetics · Pharmacology
    Studied dose
    0.1 mg/kg/day · continuous intravenous infusion · second, third, and fourth days after admissionAs given in this study (human).

    Source sentences

    Summary
    Despite continuous intravenous administration, GH levels gradually declined during the 3 treatment days, indicating increased metabolic clearance.
    3 context sentences
    Summary · context
    It was designed as a prospective, randomized, placebo-controlled trial, and performed in the medical intensive care unit of a university hospital.
    Summary · context
    Twenty patients admitted with septic shock and receiving standard parenteral nutrition served as subjects.
    Summary · context
    Treatment consisted of GH 0.1 mg/kg/day or placebo administered as continuous intravenous infusion on the second, third, and fourth days after admission.
  7. 07HumanNon-randomized trialSafety outcome

    In patients with severe sepsis, insulin resistance occurred during GH treatment.

    In plain wordsIn patients with severe sepsis, insulin resistance occurred during GH treatment.

    Peptide
    HGH (somatotropin)
    Outcome
    Not applicableInsulin resistance
    Study

    n: not reported in source

    Outcome group
    Adverse events · Metabolic and weight
    Studied dose
    0.1 mg/kg/day · continuous intravenous infusion · second, third, and fourth days after admissionAs given in this study (human).

    Source sentences

    Summary
    Side effects other than insulin resistance were not observed.
    3 context sentences
    Summary · context
    It was designed as a prospective, randomized, placebo-controlled trial, and performed in the medical intensive care unit of a university hospital.
    Summary · context
    Twenty patients admitted with septic shock and receiving standard parenteral nutrition served as subjects.
    Summary · context
    Treatment consisted of GH 0.1 mg/kg/day or placebo administered as continuous intravenous infusion on the second, third, and fourth days after admission.
  8. 08HumanNon-randomized trialSafety outcome

    In patients with severe sepsis, no side effects other than insulin resistance were observed during GH treatment.

    In plain wordsIn patients with severe sepsis, no other side effects were observed during GH treatment.

    Peptide
    HGH (somatotropin)
    Outcome
    Not applicableOther side effects
    Study

    n: not reported in source

    Outcome group
    Adverse events · Metabolic and weight
    Studied dose
    0.1 mg/kg/day · continuous intravenous infusion · second, third, and fourth days after admissionAs given in this study (human).

    Source sentences

    Summary
    Side effects other than insulin resistance were not observed.
    3 context sentences
    Summary · context
    It was designed as a prospective, randomized, placebo-controlled trial, and performed in the medical intensive care unit of a university hospital.
    Summary · context
    Twenty patients admitted with septic shock and receiving standard parenteral nutrition served as subjects.
    Summary · context
    Treatment consisted of GH 0.1 mg/kg/day or placebo administered as continuous intravenous infusion on the second, third, and fourth days after admission.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    28 Oct 2026, 02:03 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:37 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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