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Study · Measured the body's own peptide · 1992

4 results

Identification of immunoreactive forms of thymosin alpha 1 in serum and supernatants by combining HPLC and RIA.

Naylor PH, Oates KK, Coss MC, Erdos MR, Naylor CW, Goldstein AL

International journal of immunopharmacology1 Oct 1992Cited by 7 (Europe PMC)

PMID1452411 (opens in a new tab)DOI10.1016/0192-0561(92)90063-q (opens in a new tab)PepBankPUB-01452411
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

No result from this study comes from a test of the peptide.

Natural levels measured4

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

  1. 01AnimalEndogenous levelAnimal study (in vivo)Other

    In mice, serum thymosin alpha‑1 declined after irradiation but not after thymectomy.

    In plain wordsIn mice, the body's own thymosin alpha‑1 in blood fell after irradiation but not after thymus removal.

    Peptide
    Thymosin alpha-1
    Outcome
    DecreaseMouse serum thymosin alpha 1 after irradiation
    Study

    mousen: not reported in source

    Mouse irradiation and thymectomy
    Outcome group
    Endogenous peptide levels · Immune and inflammation

    Source sentences

    Summary
    Using this assay we detected a decline in mouse serum T alpha 1 following irradiation but not thymectomy, an observation consistent with the existence of an important radiation sensitive lymphoid source of serum T alpha 1.

    This result measures the body's own Thymosin alpha-1. Nobody was given the peptide. It is not evidence about taking it.

  2. 02LabEndogenous levelIn vitro (cells)Mechanism

    Thymic epithelial cells and mitogen-stimulated peripheral blood lymphocytes secreted authentic thymosin alpha‑1, but not the precursor, into culture medium.

    In plain wordsIn cells in a dish, thymus cells and white blood cells released their own thymosin alpha‑1, not the precursor.

    Peptide
    Thymosin alpha-1
    Outcome
    Not applicableSecretion of authentic thymosin alpha 1 by thymic epithelial cells and lymphocytes
    Study

    n: not reported in source

    Thymic epithelial cells and mitogen-stimulated peripheral blood lymphocytes
    Outcome group
    Endogenous peptide levels · Immune and inflammation

    Source sentences

    Summary
    The secretion of authentic T alpha 1 but not the precursor into culture medium by thymic epithelial cells as well as in mitogen-stimulated peripheral blood lymphocytes was also demonstrated by HPLC/RIA.

    This result measures the body's own Thymosin alpha-1. Nobody was given the peptide. It is not evidence about taking it.

  3. 03LabEndogenous levelIn vitro (cells)Other

    Supernatants of MCF-7 breast carcinoma cells held an immunoreactive thymosin alpha‑1 form of lower molecular weight than authentic thymosin alpha‑1.

    In plain wordsIn cells in a dish, breast cancer cells released a smaller form of the body's own thymosin alpha‑1 than thymus cells did.

    Peptide
    Thymosin alpha-1
    Outcome
    Not applicableMolecular weight of immunoreactive thymosin alpha 1 from tumor cells
    Study

    humann: not reported in source

    MCF-7 breast carcinoma cell supernatants
    Outcome group
    Endogenous peptide levels · Immune and inflammation

    Source sentences

    Summary
    HPLC analysis by molecular weight sizing columns demonstrated that unlike thymic epithelial cells or peripheral blood lymphocytes, the immunoreactive T alpha 1 (IRT alpha 1) form in the supernatants from tumor cells such as MCF-7 breast carcinoma was of a lower molecular weight than authentic T alpha 1.

    This result measures the body's own Thymosin alpha-1. Nobody was given the peptide. It is not evidence about taking it.

  4. 04LabEndogenous levelIn vitro (cell-free)Other

    By HPLC, the predominant immunoreactive form in serum and thymus was thymosin alpha‑1, not its precursor prothymosin alpha.

    In plain wordsIn lab analysis of serum and thymus, the body's own thymosin alpha‑1 was the main form found, not the precursor.

    Peptide
    Thymosin alpha-1
    Outcome
    Not applicablePredominant immunoreactive form in serum and thymus
    Study

    n: not reported in source

    HPLC and RIA of serum and thymus extracts
    Outcome group
    Endogenous peptide levels · Immune and inflammation

    Source sentences

    Summary
    Using HPLC methodologies, the predominant form of immunoreactivity in serum and thymus was T alpha 1 not the precursor.

    This result measures the body's own Thymosin alpha-1. Nobody was given the peptide. It is not evidence about taking it.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    10 Oct 2026, 08:55 UTC

    Study results updated

  2. Version 2

    9 Oct 2026, 03:03 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    9 Oct 2026, 03:02 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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