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Study · Measured the body's own peptide · 1992

2 results

The COUP transcription factor (COUP-TF) is directly involved in the regulation of oxytocin gene expression in luteinizing bovine granulosa cells.

Wehrenberg U, Ivell R, Walther N

Biochemical and biophysical research communications1 Nov 1992Cited by 21 (Europe PMC)

PMID1449499 (opens in a new tab)DOI10.1016/0006-291x(92)91585-e (opens in a new tab)PepBankPUB-01449499
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

No result from this study comes from a test of the peptide.

Natural levels measured2

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

  1. 01LabEndogenous levelEx vivo tissueMechanism

    In bovine granulosa cells and corpus luteum, COUP-TF was up-regulated under conditions where the oxytocin gene is switched off.

    In plain wordsIn cow ovary cells and tissue, COUP-TF was higher when the body's own oxytocin gene was switched off.

    Peptide
    Oxytocin
    Outcome
    Not applicableCOUP-TF expression where the oxytocin gene is switched off
    Study

    bovinen: not reported in source

    Bovine granulosa cells and corpus luteum
    Outcome group
    Receptor activity and mechanism · Reproductive and sexual health

    Source sentences

    Summary
    PCR cloning of partial cDNA sequences for bovine COUP-TF I and II and development of RNase protection assays demonstrated the up-regulation of COUP-TF in bovine granulosa cells and corpus luteum under conditions where the oxytocin gene is switched off.

    This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.

  2. 02LabEndogenous levelIn vitro (cells)Mechanism

    In bovine granulosa cells that express the oxytocin gene, the transcription factor COUP bound to the promoter region of the bovine oxytocin gene.

    In plain wordsIn cow ovary cells, a protein called COUP attached to the control region of the body's own oxytocin gene.

    Peptide
    Oxytocin
    Outcome
    Not applicableCOUP binding to the oxytocin gene promoter
    Study

    bovinen: not reported in source

    Bovine granulosa cells that express oxytocin
    Outcome group
    Receptor activity and mechanism · Reproductive and sexual health

    Source sentences

    Summary
    Competition with specific oligonucleotides in DNA-binding experiments, polyacrylamide gel electrophoresis, and recognition by specific antibodies have identified the ubiquitous transcription factor COUP as one of the nuclear proteins binding to the promoter region of the bovine oxytocin gene in endo…

    This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 20:03 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:52 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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