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Study · Animal study (in vivo) · rat · 1992

5 results

Ethanol and delta-sleep-inducing peptide: effects on brain monoamines.

Yukhananov RY, Tennilä TM, Miroshnicenko TI, Kudrin VS, Ushakov AN, Melnik EI, Michaleva II, Rayevsky KS, Airaksinen MM, Maisky AI

Pharmacology, biochemistry, and behavior1 Nov 1992Cited by 9 (Europe PMC)

PMID1448465 (opens in a new tab)DOI10.1016/0091-3057(92)90396-w (opens in a new tab)PepBankPUB-01448465
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In rats, DSIP injection reduced the level of serotonin in the medial prefrontal cortex in both high and low active groups.

    In plain wordsIn rats, DSIP injection lowered serotonin in a front brain area, in both groups of animals.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    Decrease5-HT in medial prefrontal cortex
    Study

    ratn: not reported in source

    Outcome group
    Neurotransmitters and neurotrophic factors · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    delta-Sleep-inducing peptide (DSIP) injection reduced the level of 5-HT in the medial prefrontal cortex (MFC) in both groups
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In rats, DSIP injection did not affect the concentration of dopamine or DOPAC.

    In plain wordsIn rats, DSIP injection did not change dopamine or its breakdown product DOPAC.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    No significant changeDopamine and DOPAC concentrations
    Study

    ratn: not reported in source

    Outcome group
    Neurotransmitters and neurotrophic factors · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    did not affect the concentration of DA or DOPAC
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In high active rats, DSIP injection increased homovanillic acid in the striatum.

    In plain wordsIn high active rats, DSIP injection raised a dopamine breakdown product in a deep brain area.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    IncreaseStriatal HVA in high active rats
    Study

    ratn: not reported in source

    Outcome group
    Neurotransmitters and neurotrophic factors · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    but increased HVA in the striatum of HA rats.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In rats, DSIP injected before ethanol augmented the effects of ethanol on serotonin in the medial prefrontal cortex.

    In plain wordsIn rats, DSIP given before ethanol strengthened the ethanol effect on serotonin in a front brain area.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    Direction not reportedEthanol effect on 5-HT in medial prefrontal cortex with DSIP
    Study

    ratn: not reported in source

    Comparator
    Ethanol alone
    Outcome group
    Neurotransmitters and neurotrophic factors · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    DSIP injected before ethanol administration augmented the ethanol effects on 5-HT in the MFC
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In rats, DSIP injected before ethanol attenuated the action of ethanol on 5-HIAA in the nucleus accumbens.

    In plain wordsIn rats, DSIP given before ethanol weakened the ethanol effect on a serotonin breakdown product in a deep brain area.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    Direction not reportedEthanol effect on 5-HIAA in nucleus accumbens with DSIP
    Study

    ratn: not reported in source

    Comparator
    Ethanol alone
    Outcome group
    Neurotransmitters and neurotrophic factors · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    attenuated the action of ethanol on 5-HIAA in the nucleus accumbens.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 08:55 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

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