Four synthetic oxytocin analogs with substituted phenylalanine at position 2 inhibited the uterotonic activity of oxytocin, with pA2 values from 6.0 to 8.3.
In plain wordsIn lab tests, four modified oxytocin-like molecules blocked the uterus-contracting action of oxytocin, with different strengths.
- Peptide
- Oxytocin
- Outcome
- Not applicableInhibition of oxytocin uterotonic activity by analogs
- Study
n: not reported in source
- Outcome group
- Receptor activity and mechanism · Reproductive and sexual health
Measurements
- pA2
- 6 to 8.3 NA
- oxytocin analogs
- pA2
- 8.3 NA
- dimethylphenylalanine D-erythro analog
Source sentences
All analogs were found to be inhibitors of uterotonic activity of oxytocin with pA2 values ranging from 6.0 to 8.3; the most potent one (pA2 = 8.3) contained dimethylphenylalanine of the D-erythro configuration.
1 context sentence(design, population, supporting numbers)
Four diastereomeric analogs of oxytocin containing substituted phenylalanine in position 2 were synthesized.
In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.