Effects of coadministered growth hormone (GH)-releasing hormone and GH-releasing hexapeptide on maladaptive aspects of obesity in Zucker rats.

Bercu BB, Yang SW, Masuda R, Hu CS, Walker RF

Endocrinology1 Dec 1992Cited by 10 (Europe PMC)

PMID1446617DOI10.1210/endo.131.6.1446617PepBankPUB-01446617

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study10

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone10

In this study, GHRP-6 was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking GHRP-6.

01AnimalNot a test of GHRP-6 aloneAnimal study (in vivo)Efficacy outcome
In obese Zucker rats, combined GHRH and GHRP‑6 increased pituitary weight versus saline.
In plain wordsIn rats with obesity, combined GHRH and GHRP‑6 increased pituitary weight compared with saline.
Peptide
GHRP-6
Outcome
IncreasePituitary weight
Study
ratn: not reported in source
Obese Zucker rats
Comparator
Saline-treated obese rats
Outcome group
Growth hormone and IGF-1 · Endocrine and hormones
Source sentences
Summary
Although pituitary weights and GH concentrations were higher in obese rats administered the peptides than in obese rats administered saline, stimulated GH secretion was lower in obese rats than in lean rats.
1 context sentence(design, population, supporting numbers)
Summary · context
Obese Zucker rats were coadministered GH-releasing hormone (GHRH; 3 micrograms/kg) and GH-releasing hexapeptide (GHRP-6; 300 micrograms/kg), a potent combination of synergistic GH secretagogues, once daily for 60 consecutive days.
In this study, GHRP-6 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHRP-6.
Report a problemFND-0144661701
02AnimalNot a test of GHRP-6 aloneAnimal study (in vivo)Efficacy outcome
In obese Zucker rats, combined GHRH and GHRP‑6 increased pituitary GH concentrations versus saline.
In plain wordsIn rats with obesity, combined GHRH and GHRP‑6 increased pituitary growth hormone concentrations compared with saline.
Peptide
GHRP-6
Outcome
IncreasePituitary GH concentration
Study
ratn: not reported in source
Obese Zucker rats
Comparator
Saline-treated obese rats
Outcome group
Growth hormone and IGF-1 · Endocrine and hormones
Source sentences
Summary
Although pituitary weights and GH concentrations were higher in obese rats administered the peptides than in obese rats administered saline, stimulated GH secretion was lower in obese rats than in lean rats.
1 context sentence(design, population, supporting numbers)
Summary · context
Obese Zucker rats were coadministered GH-releasing hormone (GHRH; 3 micrograms/kg) and GH-releasing hexapeptide (GHRP-6; 300 micrograms/kg), a potent combination of synergistic GH secretagogues, once daily for 60 consecutive days.
In this study, GHRP-6 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHRP-6.
Report a problemFND-0144661702
03AnimalNot a test of GHRP-6 aloneAnimal study (in vivo)Efficacy outcome
Stimulated GH secretion was lower in obese rats receiving combined GHRH and GHRP‑6 than in lean rats.
In plain wordsIn rats, stimulated growth hormone release was lower with obesity than in lean rats during combined GHRH and GHRP‑6 treatment.
Peptide
GHRP-6
Outcome
DecreaseStimulated GH secretion
Study
ratn: not reported in source
Obese Zucker rats
Comparator
Lean rats
Outcome group
Growth hormone and IGF-1 · Endocrine and hormones
Source sentences
Summary
Although pituitary weights and GH concentrations were higher in obese rats administered the peptides than in obese rats administered saline, stimulated GH secretion was lower in obese rats than in lean rats.
1 context sentence(design, population, supporting numbers)
Summary · context
Obese Zucker rats were coadministered GH-releasing hormone (GHRH; 3 micrograms/kg) and GH-releasing hexapeptide (GHRP-6; 300 micrograms/kg), a potent combination of synergistic GH secretagogues, once daily for 60 consecutive days.
In this study, GHRP-6 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHRP-6.
Report a problemFND-0144661703
04AnimalNot a test of GHRP-6 aloneAnimal study (in vivo)Efficacy outcome
Plasma IGF-I was higher in obese than lean rats regardless of GHRH and GHRP‑6 treatment.
In plain wordsIn rats, IGF-I levels were higher with obesity than in lean rats regardless of combined GHRH and GHRP‑6 treatment.
Peptide
GHRP-6
Outcome
IncreasePlasma IGF-I
Study
ratn: not reported in source
Obese Zucker rats
Comparator
Lean rats
Outcome group
Growth hormone and IGF-1 · Endocrine and hormones
Source sentences
Summary
However, compared to those in lean rats, plasma insulin-like growth factor-I and insulin concentrations were higher in the obese rats regardless of treatment.
1 context sentence(design, population, supporting numbers)
Summary · context
Obese Zucker rats were coadministered GH-releasing hormone (GHRH; 3 micrograms/kg) and GH-releasing hexapeptide (GHRP-6; 300 micrograms/kg), a potent combination of synergistic GH secretagogues, once daily for 60 consecutive days.
In this study, GHRP-6 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHRP-6.
Report a problemFND-0144661704
05AnimalNot a test of GHRP-6 aloneAnimal study (in vivo)Efficacy outcome
Plasma insulin was higher in obese than lean rats regardless of GHRH and GHRP‑6 treatment.
In plain wordsIn rats, insulin levels were higher with obesity than in lean rats regardless of combined GHRH and GHRP‑6 treatment.
Peptide
GHRP-6
Outcome
IncreasePlasma insulin
Study
ratn: not reported in source
Obese Zucker rats
Comparator
Lean rats
Outcome group
Glycemic control · Metabolic and weight
Source sentences
Summary
However, compared to those in lean rats, plasma insulin-like growth factor-I and insulin concentrations were higher in the obese rats regardless of treatment.
1 context sentence(design, population, supporting numbers)
Summary · context
Obese Zucker rats were coadministered GH-releasing hormone (GHRH; 3 micrograms/kg) and GH-releasing hexapeptide (GHRP-6; 300 micrograms/kg), a potent combination of synergistic GH secretagogues, once daily for 60 consecutive days.
In this study, GHRP-6 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHRP-6.
Report a problemFND-0144661705
06AnimalNot a test of GHRP-6 aloneAnimal study (in vivo)Efficacy outcome
In sexually mature obese rats, combined GHRH and GHRP‑6 did not alter food intake.
In plain wordsIn mature rats with obesity, combined GHRH and GHRP‑6 did not change food intake.
Peptide
GHRP-6
Outcome
No significant changeFood intake in mature rats
Study
ratn: not reported in source
Obese Zucker rats
Outcome group
Appetite and food intake · Metabolic and weight
Source sentences
Summary
The GH secretagogues did not alter food intake or body weight gain in sexually mature obese rats, whereas body weight gain was significantly increased when they were administered to prepubertal obese rats.
1 context sentence(design, population, supporting numbers)
Summary · context
Obese Zucker rats were coadministered GH-releasing hormone (GHRH; 3 micrograms/kg) and GH-releasing hexapeptide (GHRP-6; 300 micrograms/kg), a potent combination of synergistic GH secretagogues, once daily for 60 consecutive days.
In this study, GHRP-6 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHRP-6.
Report a problemFND-0144661706
07AnimalNot a test of GHRP-6 aloneAnimal study (in vivo)Efficacy outcome
In sexually mature obese rats, combined GHRH and GHRP‑6 did not alter body weight gain.
In plain wordsIn mature rats with obesity, combined GHRH and GHRP‑6 did not change body weight gain.
Peptide
GHRP-6
Outcome
No significant changeBody weight gain in mature rats
Study
ratn: not reported in source
Obese Zucker rats
Outcome group
Body weight · Metabolic and weight
Source sentences
Summary
The GH secretagogues did not alter food intake or body weight gain in sexually mature obese rats, whereas body weight gain was significantly increased when they were administered to prepubertal obese rats.
1 context sentence(design, population, supporting numbers)
Summary · context
Obese Zucker rats were coadministered GH-releasing hormone (GHRH; 3 micrograms/kg) and GH-releasing hexapeptide (GHRP-6; 300 micrograms/kg), a potent combination of synergistic GH secretagogues, once daily for 60 consecutive days.
In this study, GHRP-6 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHRP-6.
Report a problemFND-0144661707
08AnimalNot a test of GHRP-6 aloneAnimal study (in vivo)Efficacy outcome
In prepubertal obese rats, combined GHRH and GHRP‑6 increased body weight gain.
In plain wordsIn prepubertal rats with obesity, combined GHRH and GHRP‑6 increased body weight gain.
Peptide
GHRP-6
Outcome
IncreaseBody weight gain in prepubertal rats
Study
ratn: not reported in source
Obese Zucker rats
Outcome group
Body weight · Metabolic and weight
Source sentences
Summary
The GH secretagogues did not alter food intake or body weight gain in sexually mature obese rats, whereas body weight gain was significantly increased when they were administered to prepubertal obese rats.
1 context sentence(design, population, supporting numbers)
Summary · context
Obese Zucker rats were coadministered GH-releasing hormone (GHRH; 3 micrograms/kg) and GH-releasing hexapeptide (GHRP-6; 300 micrograms/kg), a potent combination of synergistic GH secretagogues, once daily for 60 consecutive days.
In this study, GHRP-6 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHRP-6.
Report a problemFND-0144661708
09AnimalNot a test of GHRP-6 aloneAnimal study (in vivo)Efficacy outcome
In obese rats, combined GHRH and GHRP‑6 improved glucose tolerance versus saline.
In plain wordsIn rats with obesity, combined GHRH and GHRP‑6 improved glucose tolerance compared with saline.
Peptide
GHRP-6
Outcome
IncreaseGlucose tolerance
Study
ratn: not reported in source
Obese Zucker rats
Comparator
Saline-treated obese rats
Outcome group
Glycemic control · Metabolic and weight
Source sentences
Summary
Although glucose tolerance was impaired in both groups of obese rats, it improved in obese rats administered GHRH and GHRP-6 compared to that in obese rats administered saline.
1 context sentence(design, population, supporting numbers)
Summary · context
Obese Zucker rats were coadministered GH-releasing hormone (GHRH; 3 micrograms/kg) and GH-releasing hexapeptide (GHRP-6; 300 micrograms/kg), a potent combination of synergistic GH secretagogues, once daily for 60 consecutive days.
In this study, GHRP-6 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHRP-6.
Report a problemFND-0144661709
10AnimalNot a test of GHRP-6 aloneAnimal study (in vivo)Efficacy outcome
In obese rats, combined GHRH and GHRP‑6 elevated plasma cholesterol compared with saline.
In plain wordsIn rats with obesity, combined GHRH and GHRP‑6 increased blood cholesterol compared with saline.
Peptide
GHRP-6
Outcome
IncreasePlasma cholesterol
Study
ratn: not reported in source
Obese Zucker rats
Comparator
Saline-treated obese rats
Outcome group
Lipids · Metabolic and weight
Source sentences
Summary
On the other hand, plasma cholesterol concentrations were elevated in obese rats administered the GH secretagogues but not saline.
1 context sentence(design, population, supporting numbers)
Summary · context
Obese Zucker rats were coadministered GH-releasing hormone (GHRH; 3 micrograms/kg) and GH-releasing hexapeptide (GHRP-6; 300 micrograms/kg), a potent combination of synergistic GH secretagogues, once daily for 60 consecutive days.
In this study, GHRP-6 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHRP-6.
Report a problemFND-0144661710

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
21 Oct 2026, 15:59 UTC
Study results updated
Version 1
9 Oct 2026, 03:13 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

Journal Article

MeSH terms

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