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Study · Randomized controlled trial · n = 270 · 1992

2 results

Depot leuprolide versus danazol in treatment of women with symptomatic endometriosis. I. Efficacy results.

Wheeler JM, Knittle JD, Miller JD

American journal of obstetrics and gynecology1 Nov 1992Cited by 65 (Europe PMC)

PMID1442992 (opens in a new tab)DOI10.1016/s0002-9378(11)91718-9 (opens in a new tab)PepBankPUB-01442992
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. 2 results from people.

  1. 01HumanRandomized controlled trialEfficacy outcome

    In women with endometriosis, leuprolide suppressed estradiol more rapidly and profoundly than danazol.

    In plain wordsIn women with endometriosis, leuprolide suppressed estradiol faster and more strongly than danazol.

    Peptide
    Leuprolide
    Outcome
    DecreaseEstradiol suppression
    Study

    n = 270

    Comparator
    Danazol
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    When compared with danazol, leuprolide depot caused a more rapid and profound suppression of estradiol.
    1 context sentence
    Summary · context
    A double-blind randomized trial of 270 patients from 22 centers compared the pretreatment and posttreatment laparoscopic extent of endometriosis.
  2. 02HumanRandomized controlled trialEfficacy outcome

    In women with endometriosis, leuprolide and danazol had similar efficacy in decreasing disease extent, pain and tenderness.

    In plain wordsIn women with endometriosis, leuprolide and danazol similarly decreased disease extent, pain and tenderness.

    Peptide
    Leuprolide
    Outcome
    Direction not reportedEndometriosis extent, pain and tenderness
    Study

    n = 270

    Comparator
    Danazol
    Outcome group
    Organ injury · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Leuprolide depot and danazol were similarly efficacious in decreasing the extent of endometriosis, as well as the pain and tenderness associated with endometriosis.
    1 context sentence
    Summary · context
    A double-blind randomized trial of 270 patients from 22 centers compared the pretreatment and posttreatment laparoscopic extent of endometriosis.

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    28 Oct 2026, 02:03 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:37 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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