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Study · Animal study (in vivo) · rat · 1992

4 results

Intact and amino-terminally shortened forms of insulin-like growth factor I induce mammary gland differentiation and development.

Ruan W, Newman CB, Kleinberg DL

Proceedings of the National Academy of Sciences of the United States of America1 Nov 1992Cited by 68 (Europe PMC)

PMID1438291 (opens in a new tab)PMCIDPMC50444 (opens in a new tab)DOI10.1073/pnas.89.22.10872 (opens in a new tab)PepBankPUB-01438291
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In hormone-treated immature male rats, des-(1-3)-IGF-I induced mammary terminal end bud development.

    In plain wordsIn rats, des-(1-3)-IGF-I induced mammary terminal end bud development.

    Peptide
    IGF-1 DES (des(1-3)IGF-I)
    Outcome
    IncreaseTerminal end bud development
    Study

    ratn: not reported in source

    Hypophysectomized, castrated, estradiol-treated sexually immature male rats
    Outcome group
    Development and maturation · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Two forms of IGF-I, intact and amino-terminally shortened [des-(1-3)-IGF-I], were found to induce the development of terminal end buds and the formation of alveolar structures in the mammary glands of hypophysectomized, castrated, and estradiol-treated sexually immature male rats.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In hormone-treated immature male rats, des-(1-3)-IGF-I induced mammary alveolar structure formation.

    In plain wordsIn rats, des-(1-3)-IGF-I induced mammary alveolar structure formation.

    Peptide
    IGF-1 DES (des(1-3)IGF-I)
    Outcome
    IncreaseAlveolar structure formation
    Study

    ratn: not reported in source

    Hypophysectomized, castrated, estradiol-treated sexually immature male rats
    Outcome group
    Development and maturation · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Two forms of IGF-I, intact and amino-terminally shortened [des-(1-3)-IGF-I], were found to induce the development of terminal end buds and the formation of alveolar structures in the mammary glands of hypophysectomized, castrated, and estradiol-treated sexually immature male rats.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In immature male rats, des-(1-3)-IGF-I was at least 5 times more potent than intact IGF-I for mammary development.

    In plain wordsIn rats, des-(1-3)-IGF-I promoted mammary development more potently than intact IGF-I.

    Peptide
    IGF-1 DES (des(1-3)IGF-I)
    Outcome
    IncreaseMammary development potency
    Study

    ratn: not reported in source

    Hypophysectomized, castrated, estradiol-treated sexually immature male rats
    Comparator
    Intact IGF-I
    Outcome group
    Development and maturation · Reproductive and sexual health
    Studied dose
    Dose not stated

    Measurements

    Relative potency
    ≥ 5 times
    versus intact IGF-I

    Source sentences

    Summary
    The effect of both forms of IGF-I was similar to that obtained with human GH, but the truncated form was at least 5 times more potent than intact IGF-I.
    1 context sentence
    Summary · context
    Two forms of IGF-I, intact and amino-terminally shortened [des-(1-3)-IGF-I], were found to induce the development of terminal end buds and the formation of alveolar structures in the mammary glands of hypophysectomized, castrated, and estradiol-treated sexually immature male rats.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In immature male rats, des-(1-3)-IGF-I produced a mammary development effect similar to human GH.

    In plain wordsIn rats, des-(1-3)-IGF-I and human GH produced similar mammary development effects.

    Peptide
    IGF-1 DES (des(1-3)IGF-I)
    Outcome
    No significant changeMammary development effect
    Study

    ratn: not reported in source

    Hypophysectomized, castrated, estradiol-treated sexually immature male rats
    Comparator
    Human GH
    Outcome group
    Development and maturation · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The effect of both forms of IGF-I was similar to that obtained with human GH, but the truncated form was at least 5 times more potent than intact IGF-I.
    1 context sentence
    Summary · context
    Two forms of IGF-I, intact and amino-terminally shortened [des-(1-3)-IGF-I], were found to induce the development of terminal end buds and the formation of alveolar structures in the mammary glands of hypophysectomized, castrated, and estradiol-treated sexually immature male rats.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 2

    21 Oct 2026, 13:52 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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