Changes of colonic vasoactive intestinal peptide and cholinergic activity in rats with chemical colitis.

Kishimoto S, Kobayashi H, Shimizu S, Haruma K, Tamaru T, Kajiyama G, Miyoshi A

Digestive diseases and sciences1 Nov 1992Cited by 36 (Europe PMC)

PMID1425074DOI10.1007/bf01299867PepBankPUB-01425074

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

No result from this study comes from a test of the peptide.

Natural levels measured4

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

01AnimalEndogenous levelAnimal study (in vivo)Other
In rats with chemical colitis, the number of colonic neurons and nerve fibers that stained for the body's own vasoactive intestinal peptide rose.
In plain wordsIn rats with colitis, more colon nerve cells and fibers carried the body's own VIP.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
IncreaseVIP-immunostained neurons and nerve fibers in colon
Study
ratn: not reported in source
Dextran sulfate-induced chemical colitis
Outcome group
Inflammation markers · Gastrointestinal
Source sentences
Summary
We observed a significant increase of immunostained neurons and nerve fibers
1 context sentence(design, population, supporting numbers)
Summary · context
Colitis was induced by administration of dextran sulfate for three months.
This result measures the body's own Vasoactive intestinal peptide (VIP, aviptadil). Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-0142507401
02AnimalEndogenous levelAnimal study (in vivo)Other
In rats with chemical colitis, the content of the body's own vasoactive intestinal peptide in the colonic wall rose significantly.
In plain wordsIn rats with colitis, the colon wall held more of the body's own VIP.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
IncreaseColonic wall VIP content
Study
ratn: not reported in source
Dextran sulfate-induced chemical colitis
Outcome group
Inflammation markers · Gastrointestinal
Source sentences
Summary
a significant rise in the colonic wall vasoactive intestinal peptide content in chemical colitis rats
1 context sentence(design, population, supporting numbers)
Summary · context
Colitis was induced by administration of dextran sulfate for three months.
This result measures the body's own Vasoactive intestinal peptide (VIP, aviptadil). Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-0142507402
03AnimalEndogenous levelAnimal study (in vivo)Other
In rats with chemical colitis, plasma concentrations of the body's own vasoactive intestinal peptide did not change significantly.
In plain wordsIn rats with colitis, blood levels of the body's own VIP did not change much.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
No significant changePlasma VIP concentration
Study
ratn: not reported in source
Dextran sulfate-induced chemical colitis
Outcome group
Inflammation markers · Gastrointestinal
Source sentences
Summary
while plasma concentrations of the peptide did not change significantly.
1 context sentence(design, population, supporting numbers)
Summary · context
Colitis was induced by administration of dextran sulfate for three months.
This result measures the body's own Vasoactive intestinal peptide (VIP, aviptadil). Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-0142507403
04AnimalEndogenous levelAnimal study (in vivo)Mechanism
In rats with chemical colitis, systemic acetylcholine significantly increased colonic and plasma concentrations of the body's own vasoactive intestinal peptide.
In plain wordsIn rats with colitis, giving acetylcholine raised the body's own VIP in the colon and blood.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
IncreaseVIP response to acetylcholine administration
Study
ratn: not reported in source
Dextran sulfate-induced chemical colitis
Outcome group
Inflammation markers · Gastrointestinal
Source sentences
Summary
Systemic administration of acetylcholine significantly increased the colonic and plasma vasoactive intestinal peptide concentrations in colitis rats.
1 context sentence(design, population, supporting numbers)
Summary · context
Colitis was induced by administration of dextran sulfate for three months.
This result measures the body's own Vasoactive intestinal peptide (VIP, aviptadil). Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-0142507404

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
12 Oct 2026, 12:58 UTC
Study results updated
Version 1
9 Oct 2026, 12:41 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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MeSH terms

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