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Study · Animal study (in vivo) · rat · 1992

5 results

Low concentrations of oxytocin suppress lordosis when infused into the lateral ventricle of female rats.

Schulze HG, Gorzalka BB

Endocrine regulations1 Mar 1992Cited by 6 (Europe PMC)

PMID1421204 (opens in a new tab)PepBankPUB-01421204
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In female rats, 0.34 ng oxytocin infused into the left lateral ventricle inhibited lordosis behavior.

    In plain wordsIn female rats, a very small dose of oxytocin infused into a side brain ventricle reduced mating posture.

    Peptide
    Oxytocin
    Outcome
    DecreaseLordosis behavior after lateral ventricle infusion
    Study

    ratn: not reported in source

    Cannulated female rats primed with estradiol benzoate and progesterone
    Comparator
    Same dose infused into the third ventricle
    Outcome group
    Sexual function · Reproductive and sexual health
    Studied dose
    0.34 ng · intracerebroventricularAs given in this study (rat).

    Source sentences

    Summary
    The infusion of 0.34 ng oxytocin into the left lateral ventricle inhibited lordosis behavior, while the same dose infused into the third ventricles of the same animals did not.
    1 context sentence
    Summary · context
    Female rats fitted with bilateral cannulae aimed at these ventricles were primed with 5 micrograms estradiol benzoate and 150 micrograms progesterone and received an infusion of 0.34 ng oxytocin into either the left lateral or the third ventricle.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In female rats, 0.34 ng oxytocin infused into the third ventricle did not inhibit lordosis behavior.

    In plain wordsIn female rats, the same small oxytocin dose infused into the third brain ventricle did not reduce mating posture.

    Peptide
    Oxytocin
    Outcome
    No significant changeLordosis behavior after third ventricle infusion
    Study

    ratn: not reported in source

    Cannulated female rats primed with estradiol benzoate and progesterone
    Comparator
    Same dose infused into the lateral ventricle
    Outcome group
    Sexual function · Reproductive and sexual health
    Studied dose
    0.34 ng · intracerebroventricularAs given in this study (rat).

    Source sentences

    Summary
    The infusion of 0.34 ng oxytocin into the left lateral ventricle inhibited lordosis behavior, while the same dose infused into the third ventricles of the same animals did not.
    1 context sentence
    Summary · context
    Female rats fitted with bilateral cannulae aimed at these ventricles were primed with 5 micrograms estradiol benzoate and 150 micrograms progesterone and received an infusion of 0.34 ng oxytocin into either the left lateral or the third ventricle.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In female rats, 3.4 ng oxytocin infused into the lateral ventricle did not inhibit lordosis, unlike 0.34 ng.

    In plain wordsIn female rats, a ten times higher oxytocin dose in a side brain ventricle did not reduce mating posture.

    Peptide
    Oxytocin
    Outcome
    No significant changeLordosis behavior after 3.4 ng lateral ventricle infusion
    Study

    ratn: not reported in source

    Cannulated female rats primed with estradiol benzoate and progesterone
    Comparator
    0.34 ng dose
    Outcome group
    Sexual function · Reproductive and sexual health
    Studied dose
    3.4 ng · intracerebroventricularAs given in this study (rat).

    Source sentences

    Summary
    In these animals the inhibition occurred with 0.34 ng but not with 3.4 ng or 34 ng of oxytocin.
    1 context sentence
    Summary · context
    In the second experiment this hypothesis was tested in another set of female rats fitted with unilateral cannulae aimed at the left lateral ventricle, primed with 5 micrograms estradiol benzoate and 150 micrograms progesterone and infused with different doses of oxytocin.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In female rats, 34 ng oxytocin infused into the lateral ventricle did not inhibit lordosis, unlike 0.34 ng.

    In plain wordsIn female rats, a hundred times higher oxytocin dose in a side brain ventricle did not reduce mating posture.

    Peptide
    Oxytocin
    Outcome
    No significant changeLordosis behavior after 34 ng lateral ventricle infusion
    Study

    ratn: not reported in source

    Cannulated female rats primed with estradiol benzoate and progesterone
    Comparator
    0.34 ng dose
    Outcome group
    Sexual function · Reproductive and sexual health
    Studied dose
    34 ng · intracerebroventricularAs given in this study (rat).

    Source sentences

    Summary
    In these animals the inhibition occurred with 0.34 ng but not with 3.4 ng or 34 ng of oxytocin.
    1 context sentence
    Summary · context
    In the second experiment this hypothesis was tested in another set of female rats fitted with unilateral cannulae aimed at the left lateral ventricle, primed with 5 micrograms estradiol benzoate and 150 micrograms progesterone and infused with different doses of oxytocin.
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In female rats, oxytocin infused into the lateral ventricle did not facilitate lordosis at 0.34, 3.4 or 34 ng.

    In plain wordsIn female rats, oxytocin in a side brain ventricle did not increase mating posture at any dose tested.

    Peptide
    Oxytocin
    Outcome
    No significant changeFacilitation of lordosis
    Study

    ratn: not reported in source

    Cannulated female rats primed with estradiol benzoate and progesterone
    Outcome group
    Sexual function · Reproductive and sexual health
    Studied dose
    0.34 ng, 3.4 ng and 34 ng · intracerebroventricularAs given in this study (rat).

    Source sentences

    Summary
    No facilitation was observed at any of these doses.
    1 context sentence
    Summary · context
    In the second experiment this hypothesis was tested in another set of female rats fitted with unilateral cannulae aimed at the left lateral ventricle, primed with 5 micrograms estradiol benzoate and 150 micrograms progesterone and infused with different doses of oxytocin.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 20:03 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:51 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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