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Study · Measured the body's own peptide · 1992

3 results

The oxytocin positive elements in the hypothalamic magnocellular nuclei of rats treated with histamine.

López-Muñiz A, Cuesta Fernández I, de Miguel J, Bengoechea E, Pérez-Casas A

Biological structures and morphogenesis1 Jan 1992

PMID1420594 (opens in a new tab)PepBankPUB-01420594
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

No result from this study comes from a test of the peptide.

Natural levels measured3

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

  1. 01AnimalEndogenous levelAnimal study (in vivo)Mechanism

    In male rats, intracerebroventricular histamine increased the number of strongly labelled oxytocin-positive neurons and pathways compared with controls.

    In plain wordsIn rats, histamine given into the brain ventricles increased staining of the body's own oxytocin in hypothalamic neurons.

    Peptide
    Oxytocin
    Outcome
    IncreaseOxytocin-positive neurons and pathways after intracerebroventricular histamine
    Study

    ratn = 20

    Hypothalamic nuclei of male rats
    Comparator
    Control rats
    Outcome group
    Endogenous peptide levels · Nervous system and cognition

    Source sentences

    Summary
    In HA treated rats, icv, numerous neurons and pathways were observed strongly labeled.
    1 context sentence
    Summary · context
    The rats subdivided into five groups: 20 control rats; 20 rats treated with physiological saline intraperitoneal via (ip); 20 rats treated with physiological saline intracerebroventricular via (icv); 20 histamine (HA) treated rats, ip; and 20 HA treated rats, icv.

    This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.

  2. 02AnimalEndogenous levelAnimal study (in vivo)Mechanism

    In male rats given intracerebroventricular histamine, large droplets appeared in the supraoptic and paraventricular nuclei.

    In plain wordsIn rats, histamine given into the brain ventricles was followed by large droplets in two hypothalamic areas that hold the body's own oxytocin.

    Peptide
    Oxytocin
    Outcome
    Not applicableLarge droplets in SON and PVN after intracerebroventricular histamine
    Study

    ratn = 20

    Hypothalamic nuclei of male rats
    Comparator
    Control rats
    Outcome group
    Endogenous peptide levels · Nervous system and cognition

    Source sentences

    Summary
    Large droplets appear in the SON and in the PVN of these animals.
    1 context sentence
    Summary · context
    The rats subdivided into five groups: 20 control rats; 20 rats treated with physiological saline intraperitoneal via (ip); 20 rats treated with physiological saline intracerebroventricular via (icv); 20 histamine (HA) treated rats, ip; and 20 HA treated rats, icv.

    This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.

  3. 03AnimalEndogenous levelAnimal study (in vivo)Mechanism

    In male rats, intraperitoneal histamine left the oxytocin-positive material similar to that of control rats.

    In plain wordsIn rats, histamine injected into the abdomen did not change the body's own oxytocin staining compared with controls.

    Peptide
    Oxytocin
    Outcome
    No significant changeOxytocin-positive material after intraperitoneal histamine
    Study

    ratn = 20

    Hypothalamic nuclei of male rats
    Comparator
    Control rats
    Outcome group
    Endogenous peptide levels · Nervous system and cognition

    Source sentences

    Summary
    In HA treated rats, ip, the oxytocin positive material is similar to that observed in the control rats.
    1 context sentence
    Summary · context
    The rats subdivided into five groups: 20 control rats; 20 rats treated with physiological saline intraperitoneal via (ip); 20 rats treated with physiological saline intracerebroventricular via (icv); 20 histamine (HA) treated rats, ip; and 20 HA treated rats, icv.

    This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 20:03 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:52 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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