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Study · Measured the body's own peptide · 1992

3 results

Alterations in oxytocin prohormone processing during early development in the fetal sheep.

Morris M, Castro M, Rose JC

The American journal of physiology1 Sept 1992Cited by 14 (Europe PMC)

PMID1415665 (opens in a new tab)DOI10.1152/ajpregu.1992.263.3.r738 (opens in a new tab)PepBankPUB-01415665
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

No result from this study comes from a test of the peptide.

Natural levels measured3

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

  1. 01AnimalEndogenous levelAnimal study (in vivo)Mechanism

    In fetal sheep, plasma levels of the extended oxytocin form OT-X were higher at 94 than at 138 days of gestation.

    In plain wordsIn fetal sheep, blood levels of an extended form of the body's own oxytocin were higher early in development.

    Peptide
    Oxytocin
    Outcome
    DecreasePlasma OT-X at 94 vs 138 days of gestation
    Study

    sheepn: not reported in source

    Comparator
    138 days of gestation
    Outcome group
    Aging markers · Endocrine and hormones

    Measurements

    Plasma OT-X
    35.7 pg/ml
    94 days
    Plasma OT-X
    14.3 pg/ml
    138 days

    Source sentences

    Summary
    Plasma levels of the COOH-terminal extended forms, OT-X, were highest early in development, 35.7 +/- 9.8 vs. 14.3 +/- 5.7 pg/ml (94 vs. 138 days).
    1 context sentence
    Summary · context
    Using specific antisera that recognize the amidated and the COOH-terminal extended forms of OT, we measured arterial and venous levels of the OT peptides in fetal sheep plasma at 94 and 138 days of gestation.

    This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.

  2. 02AnimalEndogenous levelAnimal study (in vivo)Mechanism

    In fetal sheep, the ratio of OT-X to amidated oxytocin in plasma was higher in the young fetus than late in gestation.

    In plain wordsIn fetal sheep, the share of unfinished versus finished body's own oxytocin in blood was higher in the younger fetus.

    Peptide
    Oxytocin
    Outcome
    DecreasePlasma OT-X to OT ratio at 94 vs 138 days
    Study

    sheepn: not reported in source

    Comparator
    138 days of gestation
    Outcome group
    Aging markers · Endocrine and hormones

    Measurements

    OT-X to OT ratio
    35
    94 days
    OT-X to OT ratio
    3.1
    138 days

    Source sentences

    Summary
    The ratio of the plasma peptides, OT-X to OT, was higher in the young fetus (35 +/- 11.6 vs. 3.1 +/- 1.3, 94 vs. 138 days).
    1 context sentence
    Summary · context
    Using specific antisera that recognize the amidated and the COOH-terminal extended forms of OT, we measured arterial and venous levels of the OT peptides in fetal sheep plasma at 94 and 138 days of gestation.

    This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.

  3. 03AnimalEndogenous levelAnimal study (in vivo)Mechanism

    In fetal sheep, umbilical artery-umbilical vein differences of oxytocin peptides changed with development, with positive values in late gestation.

    In plain wordsIn fetal sheep, the difference in the body's own oxytocin between umbilical vessels changed with age.

    Peptide
    Oxytocin
    Outcome
    MixedUmbilical artery-vein difference of oxytocin peptides
    Study

    sheepn: not reported in source

    Outcome group
    Aging markers · Endocrine and hormones

    Source sentences

    Summary
    There were also developmental changes in the umbilical artery-umbilical vein differences, with positive values noted in late gestation.
    1 context sentence
    Summary · context
    Using specific antisera that recognize the amidated and the COOH-terminal extended forms of OT, we measured arterial and venous levels of the OT peptides in fetal sheep plasma at 94 and 138 days of gestation.

    This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 20:03 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:52 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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