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Study · Measured the body's own peptide · 1992

2 results

Single-step isolation and sequencing of vasopressin and oxytocin precursors.

North WG, O'Connor EF, González CB

Peptides1 Mar 1992Cited by 4 (Europe PMC)

PMID1409017 (opens in a new tab)DOI10.1016/0196-9781(92)90127-o (opens in a new tab)PepBankPUB-01409017
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: CC BY-NC-ND. Results still quote short attributed sentences.

Results from this study2

No result from this study comes from a test of the peptide.

Natural levels measured2

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

  1. 01AnimalEndogenous levelAnimal study (in vivo)Mechanism

    In rat supraoptic nuclei, a 16,000 dalton nonglycosylated protein related to oxytocin biosynthesis was recovered, with an N-terminal oxytocin sequence placement of 35S-cysteine.

    In plain wordsIn rats, a 16,000 dalton precursor of the body's own oxytocin was found in a brain region that makes the hormone.

    Peptide
    Oxytocin
    Outcome
    Not applicableOxytocin-related precursor protein in supraoptic nuclei
    Study

    ratn: not reported in source

    Outcome group
    Receptor activity and mechanism · Endocrine and hormones

    Source sentences

    Summary
    One nonglycosylated protein of 16,000 daltons related to oxytocin biosynthesis was recovered from the SON, and this protein also had a 35S-cysteine placement consistent with an N-terminal OT sequence.
    1 context sentence
    Summary · context
    35S-Cysteine and 3H-fucose were microinjected into rat supraoptic nuclei (SON), and proteins and peptides related to the biosynthesis of vasopressin (VP) and oxytocin (OT) were isolated at various times from the supraoptic nuclei and neural lobe by employing a one-step procedure of high performance…

    This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.

  2. 02AnimalEndogenous levelAnimal study (in vivo)Mechanism

    In rats, the oxytocin preprohormone lost its entire leader-peptide structure before, or shortly after, packaging in the Golgi.

    In plain wordsIn rats, the precursor of the body's own oxytocin loses its leader piece early, around packaging in the cell.

    Peptide
    Oxytocin
    Outcome
    Not applicableLoss of leader-peptide structure from oxytocin preprohormone
    Study

    ratn: not reported in source

    Outcome group
    Receptor activity and mechanism · Endocrine and hormones

    Source sentences

    Summary
    These data provide the first sequential evidence that prior to, or shortly after, packaging in the Golgi the preprohormones of VP and OT have lost their entire leader-peptide structures.
    1 context sentence
    Summary · context
    35S-Cysteine and 3H-fucose were microinjected into rat supraoptic nuclei (SON), and proteins and peptides related to the biosynthesis of vasopressin (VP) and oxytocin (OT) were isolated at various times from the supraoptic nuclei and neural lobe by employing a one-step procedure of high performance…

    This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 20:03 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:52 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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