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Study · Animal study (in vivo) · rat · 1992

3 results

Content of norepinephrine and serotonin in symmetrical divisions of the brain of rats in the norm during learning and with the administration of peptides.

Kruglikov RI, Orlova NV, Getsova VM

Neuroscience and behavioral physiology1 Mar 1992Cited by 4 (Europe PMC)

PMID1407501 (opens in a new tab)DOI10.1007/bf01192384 (opens in a new tab)PepBankPUB-01407501
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Mechanism

    In rats, systemic ACTH4-7 pro-gly-pro essentially did not alter the serotonin content of the brain.

    In plain wordsIn rats, the Semax-related peptide ACTH4-7 pro-gly-pro did not change serotonin content in the brain.

    Peptide
    Semax
    Outcome
    No significant changeSerotonin (5-HT) content in brain
    Study

    ratn: not reported in source

    Rat brain regions
    Outcome group
    Neurotransmitters and neurotrophic factors · Nervous system and cognition
    Studied dose
    Dose not stated · systemicAs given in this study (rat).

    Source sentences

    Summary
    The systemic administration of DG-AVP, ACTH4-7 pro-gly-pro, and dalargin essentially did not alter the 5-HT content
    1 context sentence
    Summary · context
    The content of norepinephrine (NE) and serotonin (5-HT) in the right and left halves of the brain of rats was compared in the norm, during the development of defensive two-way avoidance conditioned reflexes (TWACR), and with the administration of peptides which influence learning and memory, namely…
  2. 02AnimalAnimal study (in vivo)Mechanism

    In rats, systemic ACTH4-7 pro-gly-pro decreased the norepinephrine content in the cortex and in the rest of the brain.

    In plain wordsIn rats, the Semax-related peptide ACTH4-7 pro-gly-pro lowered norepinephrine in the cortex and rest of the brain.

    Peptide
    Semax
    Outcome
    DecreaseNorepinephrine (NE) content in cortex and rest of brain
    Study

    ratn: not reported in source

    Rat brain regions
    Outcome group
    Neurotransmitters and neurotrophic factors · Nervous system and cognition
    Studied dose
    Dose not stated · systemicAs given in this study (rat).

    Source sentences

    Summary
    The systemic administration of DG-AVP, ACTH4-7 pro-gly-pro, and dalargin essentially did not alter the 5-HT content, and decreased the NE content in the cortex and in the rest of the brain.
    1 context sentence
    Summary · context
    The content of norepinephrine (NE) and serotonin (5-HT) in the right and left halves of the brain of rats was compared in the norm, during the development of defensive two-way avoidance conditioned reflexes (TWACR), and with the administration of peptides which influence learning and memory, namely…
  3. 03AnimalAnimal study (in vivo)Mechanism

    In rats, after peptide administration including ACTH4-7 pro-gly-pro the norepinephrine content of the right and left hemisphere evened out.

    In plain wordsIn rats, after the peptides were given, norepinephrine levels in the left and right brain halves became equal.

    Peptide
    Semax
    Outcome
    DecreaseNorepinephrine asymmetry between hemispheres
    Study

    ratn: not reported in source

    Rat brain regions
    Outcome group
    Neurotransmitters and neurotrophic factors · Nervous system and cognition
    Studied dose
    Dose not stated · systemicAs given in this study (rat).

    Source sentences

    Summary
    The systemic administration of DG-AVP, ACTH4-7 pro-gly-pro, and dalargin essentially did not alter the 5-HT content, and decreased the NE content in the cortex and in the rest of the brain. In the process the NE content of the right and left hemisphere evened out.
    1 context sentence
    Summary · context
    The content of norepinephrine (NE) and serotonin (5-HT) in the right and left halves of the brain of rats was compared in the norm, during the development of defensive two-way avoidance conditioned reflexes (TWACR), and with the administration of peptides which influence learning and memory, namely…

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 10:21 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 12:40 UTC

    First added · source update from Europe PMC

Subjects

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