In healthy men, the GH response to a GHRP bolus persisted during pituitary desensitization to GHRH, whereas the response to GHRH was abolished.
In plain wordsIn healthy men, the growth hormone response to GHRP persisted when the response to GHRH was blocked.
- Peptide
- GHRP-6
- Outcome
- No significant changeGH response to GHRP during GHRH-induced pituitary desensitization
- Study
n = 5
- Outcome group
- Growth hormone and IGF-1 · Endocrine and hormones
- Studied dose
- 1 microgram/kg body weight · intravenousAs given in this study (human).
Source sentences
GH response to bolus GHRH was abolished by GHRH infusion, whereas GH response to GHRP persisted under the same conditions.
2 context sentences(design, population, supporting numbers)
In five healthy men on six occasions, we infused saline (sal) or 1 microgram/kg.h GHRH-44 for 6 h.
After 4 h, a bolus of sal, GHRH-44 1 microgram/kg body weight, or GHRP 1 microgram/kg body weight was given iv.