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Study · Ex vivo tissue · guinea pig, rat and dog · 1992

2 results

Contractile activity of vasotocin, oxytocin, and vasopressin on mammalian prostate.

Bodanszky M, Sharaf H, Roy JB, Said SI

European journal of pharmacology1 Jun 1992Cited by 35 (Europe PMC)

PMID1397015 (opens in a new tab)DOI10.1016/0014-2999(92)90376-f (opens in a new tab)PepBankPUB-01397015
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabEx vivo tissueEfficacy outcome

    In guinea pig, rat, canine and human prostates, oxytocin contracted the tissue with potency and efficacy comparable to noradrenaline and methacholine.

    In plain wordsIn lab tests on prostate tissue from four species, oxytocin made the muscle contract about as strongly as noradrenaline and methacholine.

    Peptide
    Oxytocin
    Outcome
    IncreaseProstate contraction
    Study

    guinea pig, rat, dog, humann: not reported in source

    Comparator
    Noradrenaline and methacholine
    Outcome group
    Sexual function · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The neurohypophyseal peptides arginine vasotocin, oxytocin and arginine vasopressin contracted guinea pig, rat, canine and human prostates with potencies and efficacies that were comparable to those of noradrenaline and methacholine.
  2. 02LabEx vivo tissueEfficacy outcome

    In prostate tissue, oxytocin raised tone and elicited contractions at 10(-9) or 10(-8) M, with efficacy below arginine vasotocin and above arginine vasopressin.

    In plain wordsIn lab tests on prostate tissue, oxytocin raised muscle tone at very low concentrations, ranking between two related peptides.

    Peptide
    Oxytocin
    Outcome
    IncreaseProstatic tone and contraction at low concentrations
    Study

    guinea pig, rat, dog, humann: not reported in source

    Comparator
    Arginine vasotocin and arginine vasopressin
    Outcome group
    Sexual function · Reproductive and sexual health
    Studied dose
    10(-9) or 10(-8) MAs given in this study (guinea pig, rat, dog, human).

    Source sentences

    Summary
    All three neuropeptides raised prostatic tone and elicited contractions at 10(-9) or 10(-8) M, with an order of efficacy: arginine vasotocin greater than oxytocin greater than arginine vasopressin.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 20:03 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:52 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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