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Study · Measured the body's own peptide · 1992

2 results

The vasopressin and oxytocin neurohypophysial content as influenced by bleeding or dehydration: effect of cholecystokinin octapeptide.

Lewandowska A, Głowacka A, Guzek JW

Journal of physiology and pharmacology : an official journal of the Polish Physiological Society1 Jun 1992Cited by 2 (Europe PMC)

PMID1392012 (opens in a new tab)PepBankPUB-01392012
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

No result from this study comes from a test of the peptide.

Natural levels measured2

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

  1. 01AnimalEndogenous levelAnimal study (in vivo)Mechanism

    In dehydrated rats, CCK-8 reduced the dehydration-induced fall in neurohypophysial content of the body's own oxytocin.

    In plain wordsIn dehydrated rats, CCK-8 lessened the fall in the body's own oxytocin stored in the pituitary gland.

    Peptide
    Oxytocin
    Outcome
    IncreaseNeurohypophysial oxytocin content in dehydrated rats given CCK-8
    Study

    ratn: not reported in source

    Comparator
    Untreated dehydrated or haemorrhaged rats
    Outcome group
    Sex hormones and fertility · Endocrine and hormones

    Source sentences

    Summary
    The decrease of neurohypophysial vasopressin and oxytocin content, brought about by dehydration, was significantly less marked in animals treated with CCK-8.
    2 context sentences
    Summary · context
    The effect of CCK-8 (50 ng, i.c.v.) on the neurohypophysial vasopressin and oxytocin storage was estimated in haemorrhaged (1 ml per 100 g b.w.) male Wistar rats.
    Summary · context
    In another experimental series rats dehydrated for three days were given CCK-8 in a daily i.c.v. dose of 50 ng.

    This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.

  2. 02AnimalEndogenous levelAnimal study (in vivo)Mechanism

    In haemorrhaged rats, earlier i.c.v. CCK-8 completely inhibited the depletion of neurohypophysial content of the body's own oxytocin.

    In plain wordsIn rats after blood loss, CCK-8 given beforehand fully prevented the fall in the body's own oxytocin stored in the pituitary gland.

    Peptide
    Oxytocin
    Outcome
    IncreaseNeurohypophysial oxytocin content in haemorrhaged rats given CCK-8
    Study

    ratn: not reported in source

    Comparator
    Untreated dehydrated or haemorrhaged rats
    Outcome group
    Sex hormones and fertility · Endocrine and hormones

    Source sentences

    Summary
    The depletion of neurohypophysial vasopressin and oxytocin content in haemorrhaged animals could be completely inhibited by earlier i.c.v. administration of CCK-8.
    2 context sentences
    Summary · context
    The effect of CCK-8 (50 ng, i.c.v.) on the neurohypophysial vasopressin and oxytocin storage was estimated in haemorrhaged (1 ml per 100 g b.w.) male Wistar rats.
    Summary · context
    In another experimental series rats dehydrated for three days were given CCK-8 in a daily i.c.v. dose of 50 ng.

    This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 20:03 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:51 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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