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Study · In vitro (cells) · rat · 1992

2 results

Granulosa cell-derived insulin-like growth factor (IGF) binding proteins are inhibitory to IGF-I hormonal action. Evidence derived from the use of a truncated IGF-I analogue.

Adashi EY, Resnick CE, Ricciarelli E, Hurwitz A, Kokia E, Tedeschi C, Botero L, Hernandez ER, Rosenfeld RG, Carlsson-Skwirut C

The Journal of clinical investigation1 Oct 1992Cited by 25 (Europe PMC)

PMID1383276 (opens in a new tab)PMCIDPMC443207 (opens in a new tab)DOI10.1172/jci116028 (opens in a new tab)PepBankPUB-01383276
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Activity measurement

    In rat granulosa cells with IGFBPs, des(1‑3)IGF-I was 10-fold more potent than intact IGF-I at promoting FSH-stimulated progesterone accumulation.

    In plain wordsIn cells with binding proteins, des(1‑3)IGF-I promoted FSH-stimulated progesterone accumulation more potently than intact IGF-I.

    Peptide
    IGF-1 DES (des(1-3)IGF-I)
    Outcome
    IncreaseProgesterone accumulation potency with IGFBPs
    Study

    ratn: not reported in source

    Cultured granulosa cells
    Comparator
    Intact IGF-I
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated

    Measurements

    Relative potency
    10 fold
    IGFBP-replete conditions

    Source sentences

    Summary
    Given IGFBP-replete circumstances, des(1-3)IGF-I proved more potent (10-fold) than its intact counterpart in promoting the follicle stimulating hormone (FSH)-stimulated accumulation of progesterone by cultured rat granulosa cells.
  2. 02LabIn vitro (cells)Activity measurement

    In rat granulosa cells depleted of IGFBPs, des(1‑3)IGF-I and intact IGF-I were virtually equipotent.

    In plain wordsIn cells without binding proteins, des(1‑3)IGF-I and intact IGF-I had virtually equal potency.

    Peptide
    IGF-1 DES (des(1-3)IGF-I)
    Outcome
    No significant changeProgesterone accumulation potency without IGFBPs
    Study

    ratn: not reported in source

    Cultured granulosa cells
    Comparator
    Intact IGF-I
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In contrast, des(1-3)IGF-I proved virtually equipotent to the unmodified principle under IGFBP-deplete circumstances.
    1 context sentence
    Summary · context
    Given IGFBP-replete circumstances, des(1-3)IGF-I proved more potent (10-fold) than its intact counterpart in promoting the follicle stimulating hormone (FSH)-stimulated accumulation of progesterone by cultured rat granulosa cells.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 2

    21 Oct 2026, 13:52 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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