Regulation of secretion by vasoactive intestinal peptide in isolated perfused rat submandibular glands.

Turner JT, Camden JM

Archives of oral biology1 Apr 1992Cited by 10 (Europe PMC)

PMID1381577DOI10.1016/0003-9969(92)90050-iPepBankPUB-01381577

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study12

8 results from studies that gave the peptide. No result from this study comes from people.

01LabEx vivo tissueEfficacy outcome
In perfused rat submandibular glands, VIP alone produced a modest, sustained saliva flow with a biphasic dose-response curve, greatest at 1 nM and reduced at lower and higher concentrations.
In plain wordsIn rat salivary glands removed from the body, VIP alone produced a modest flow of saliva, largest at a middle dose.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
MixedSaliva volume with VIP alone
Study
ratn = 4
Isolated perfused rat submandibular glands
Outcome group
Gastrointestinal function · Gastrointestinal
Studied dose
1 nM · perfusionAs given in this study (rat).
Measurements
Saliva volume in first 5 min
28.5 microliters
1 nM VIP
Source sentences
Summary
In the absence of other secretagogues, VIP produced a modest, sustained saliva flow with a biphasic dose-response curve in which saliva volume was greatest at 1 nM VIP (28.5 +/- 3.8 microliters in the first 5 min, n = 4) but reduced at lower and higher concentrations.
1 context sentence(design, population, supporting numbers)
Summary · context
The isolated, perfused gland was used to examine the regulation of saliva volume and protein content by vasoactive intestinal peptide (VIP).
Report a problemFND-0138157701
02LabEx vivo tissueEfficacy outcome
In perfused rat submandibular glands, the protein concentration in saliva with VIP was substantially higher than with 30 nM acetylcholine.
In plain wordsIn rat salivary glands removed from the body, saliva made with VIP held much more protein than saliva made with acetylcholine.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
IncreaseSaliva protein concentration with VIP versus acetylcholine
Study
ratn: not reported in source
Isolated perfused rat submandibular glands
Comparator
30 nM acetylcholine
Outcome group
Gastrointestinal function · Gastrointestinal
Studied dose
Dose not stated · perfusionAs given in this study (rat).
Measurements
Saliva protein concentration
0.86 micrograms/microliters
VIP
Saliva protein concentration
0.06 micrograms/microliters
30 nM acetylcholine
Source sentences
Summary
The protein concentration in saliva released in response to VIP (0.86 +/- 0.13 micrograms/microliters) was substantially higher than with 30 nM acetylcholine (0.06 +/- 0.02 micrograms/microliters) or 1 nM substance P (0.30 +/- 0.05 micrograms/microliters).
1 context sentence(design, population, supporting numbers)
Summary · context
The isolated, perfused gland was used to examine the regulation of saliva volume and protein content by vasoactive intestinal peptide (VIP).
Report a problemFND-0138157702
03LabEx vivo tissueEfficacy outcome
In perfused rat submandibular glands, the protein concentration in saliva with VIP was substantially higher than with 1 nM substance P.
In plain wordsIn rat salivary glands removed from the body, saliva made with VIP held much more protein than saliva made with substance P.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
IncreaseSaliva protein concentration with VIP versus substance P
Study
ratn: not reported in source
Isolated perfused rat submandibular glands
Comparator
1 nM substance P
Outcome group
Gastrointestinal function · Gastrointestinal
Studied dose
Dose not stated · perfusionAs given in this study (rat).
Measurements
Saliva protein concentration
0.86 micrograms/microliters
VIP
Saliva protein concentration
0.3 micrograms/microliters
1 nM substance P
Source sentences
Summary
The protein concentration in saliva released in response to VIP (0.86 +/- 0.13 micrograms/microliters) was substantially higher than with 30 nM acetylcholine (0.06 +/- 0.02 micrograms/microliters) or 1 nM substance P (0.30 +/- 0.05 micrograms/microliters).
1 context sentence(design, population, supporting numbers)
Summary · context
The isolated, perfused gland was used to examine the regulation of saliva volume and protein content by vasoactive intestinal peptide (VIP).
Report a problemFND-0138157703
04LabEx vivo tissueEfficacy outcome
In perfused rat submandibular glands, adding VIP did not increase acetylcholine-stimulated flow in the first 5 min.
In plain wordsIn rat salivary glands removed from the body, adding VIP did not raise acetylcholine-driven saliva flow in the first 5 minutes.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
No significant changeAcetylcholine-stimulated flow with added VIP, first 5 min
Study
ratn: not reported in source
Isolated perfused rat submandibular glands
Comparator
Acetylcholine alone
Outcome group
Gastrointestinal function · Gastrointestinal
Studied dose
Dose not stated · perfusionAs given in this study (rat).
Source sentences
Summary
inclusion of VIP did not increase acetylcholine-stimulated flow in the first 5 min
1 context sentence(design, population, supporting numbers)
Summary · context
The isolated, perfused gland was used to examine the regulation of saliva volume and protein content by vasoactive intestinal peptide (VIP).
Report a problemFND-0138157706
05LabEx vivo tissueEfficacy outcome
In perfused rat submandibular glands, adding VIP to acetylcholine produced a higher sustained flow over the next hour.
In plain wordsIn rat salivary glands removed from the body, adding VIP to acetylcholine gave a higher saliva flow over the following hour.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
IncreaseAcetylcholine-stimulated flow with added VIP, sustained
Study
ratn: not reported in source
Isolated perfused rat submandibular glands
Comparator
Acetylcholine alone
Outcome group
Gastrointestinal function · Gastrointestinal
Studied dose
Dose not stated · perfusionAs given in this study (rat).
Source sentences
Summary
produced a higher sustained flow over the next hour.
1 context sentence(design, population, supporting numbers)
Summary · context
The isolated, perfused gland was used to examine the regulation of saliva volume and protein content by vasoactive intestinal peptide (VIP).
Report a problemFND-0138157707
06LabEx vivo tissueEfficacy outcome
In perfused rat submandibular glands, VIP added after acetylcholine transiently enhanced saliva volume in a monophasic, dose-dependent manner, with effects at 1 pM VIP and higher.
In plain wordsIn rat salivary glands removed from the body, adding VIP after acetylcholine briefly increased saliva volume, more at higher doses.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
IncreaseSaliva volume when VIP was added after acetylcholine
Study
ratn: not reported in source
Isolated perfused rat submandibular glands
Comparator
Acetylcholine alone
Outcome group
Gastrointestinal function · Gastrointestinal
Studied dose
1 pM and higher · perfusionAs given in this study (rat).
Source sentences
Summary
After stimulation with acetylcholine, subsequent addition of VIP transiently enhanced saliva volume and protein content in a monophasic, dose-dependent manner with effects at 1 pM VIP and higher.
1 context sentence(design, population, supporting numbers)
Summary · context
The isolated, perfused gland was used to examine the regulation of saliva volume and protein content by vasoactive intestinal peptide (VIP).
Report a problemFND-0138157708
07LabEx vivo tissueEfficacy outcome
In perfused rat submandibular glands, VIP added after acetylcholine transiently enhanced saliva protein content in a monophasic, dose-dependent manner, with effects at 1 pM VIP and higher.
In plain wordsIn rat salivary glands removed from the body, adding VIP after acetylcholine briefly increased saliva protein, more at higher doses.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
IncreaseSaliva protein content when VIP was added after acetylcholine
Study
ratn: not reported in source
Isolated perfused rat submandibular glands
Comparator
Acetylcholine alone
Outcome group
Gastrointestinal function · Gastrointestinal
Studied dose
1 pM and higher · perfusionAs given in this study (rat).
Source sentences
Summary
After stimulation with acetylcholine, subsequent addition of VIP transiently enhanced saliva volume and protein content in a monophasic, dose-dependent manner with effects at 1 pM VIP and higher.
1 context sentence(design, population, supporting numbers)
Summary · context
The isolated, perfused gland was used to examine the regulation of saliva volume and protein content by vasoactive intestinal peptide (VIP).
Report a problemFND-0138157709
08LabEx vivo tissueEfficacy outcome
In perfused rat submandibular glands, the responses to VIP differed from those to other cAMP-mobilizing agents.
In plain wordsIn rat salivary glands removed from the body, VIP produced different responses from other agents that raise cyclic AMP.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
Not applicableResponses to VIP versus other cAMP-mobilizing agents
Study
ratn: not reported in source
Isolated perfused rat submandibular glands
Comparator
Other cAMP-mobilizing agents
Outcome group
Gastrointestinal function · Gastrointestinal
Studied dose
Dose not stated · perfusionAs given in this study (rat).
Source sentences
Summary
The responses were different for VIP compared with other cAMP-mobilizing agents
1 context sentence(design, population, supporting numbers)
Summary · context
The isolated, perfused gland was used to examine the regulation of saliva volume and protein content by vasoactive intestinal peptide (VIP).
Report a problemFND-0138157710

Studies that did not test the peptide alone4

In this study, Vasoactive intestinal peptide (VIP, aviptadil) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Vasoactive intestinal peptide (VIP, aviptadil).

09LabNot a test of Vasoactive intestinal peptide (VIP, aviptadil) aloneEx vivo tissueEfficacy outcome
In perfused rat submandibular glands, VIP and substance P together were synergistic for saliva volume in the first 5 min of stimulation.
In plain wordsIn rat salivary glands removed from the body, VIP and substance P together raised saliva volume more than expected from each alone.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
IncreaseSaliva volume with VIP plus substance P
Study
ratn: not reported in source
Isolated perfused rat submandibular glands
Comparator
VIP alone and substance P alone
Outcome group
Gastrointestinal function · Gastrointestinal
Source sentences
Summary
During the first 5 min of stimulation, VIP and substance P were synergistic in terms of volume and protein content
1 context sentence(design, population, supporting numbers)
Summary · context
The isolated, perfused gland was used to examine the regulation of saliva volume and protein content by vasoactive intestinal peptide (VIP).
In this study, Vasoactive intestinal peptide (VIP, aviptadil) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Vasoactive intestinal peptide (VIP, aviptadil).
Report a problemFND-0138157704
10LabNot a test of Vasoactive intestinal peptide (VIP, aviptadil) aloneEx vivo tissueEfficacy outcome
In perfused rat submandibular glands, VIP and substance P together were synergistic for saliva protein content in the first 5 min of stimulation.
In plain wordsIn rat salivary glands removed from the body, VIP and substance P together raised saliva protein more than expected from each alone.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
IncreaseSaliva protein content with VIP plus substance P
Study
ratn: not reported in source
Isolated perfused rat submandibular glands
Comparator
VIP alone and substance P alone
Outcome group
Gastrointestinal function · Gastrointestinal
Source sentences
Summary
During the first 5 min of stimulation, VIP and substance P were synergistic in terms of volume and protein content
1 context sentence(design, population, supporting numbers)
Summary · context
The isolated, perfused gland was used to examine the regulation of saliva volume and protein content by vasoactive intestinal peptide (VIP).
In this study, Vasoactive intestinal peptide (VIP, aviptadil) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Vasoactive intestinal peptide (VIP, aviptadil).
Report a problemFND-0138157705
11LabNot a test of Vasoactive intestinal peptide (VIP, aviptadil) aloneEx vivo tissueMechanism
In perfused rat submandibular glands, a VIP antagonist blocked the VIP enhancement of saliva volume.
In plain wordsIn rat salivary glands removed from the body, a VIP blocker prevented the extra saliva volume that VIP causes.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
DecreaseVIP antagonist effect on VIP enhancement of saliva volume
Study
ratn: not reported in source
Isolated perfused rat submandibular glands
Comparator
VIP without antagonist
Outcome group
Gastrointestinal function · Gastrointestinal
Source sentences
Summary
a VIP antagonist blocked the VIP enhancement of saliva volume
1 context sentence(design, population, supporting numbers)
Summary · context
The isolated, perfused gland was used to examine the regulation of saliva volume and protein content by vasoactive intestinal peptide (VIP).
In this study, Vasoactive intestinal peptide (VIP, aviptadil) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Vasoactive intestinal peptide (VIP, aviptadil).
Report a problemFND-0138157711
12LabNot a test of Vasoactive intestinal peptide (VIP, aviptadil) aloneEx vivo tissueMechanism
In perfused rat submandibular glands, a VIP antagonist did not block the VIP-induced increase in saliva protein.
In plain wordsIn rat salivary glands removed from the body, a VIP blocker did not prevent the protein increase that VIP causes.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
No significant changeVIP antagonist effect on VIP-induced increase in saliva protein
Study
ratn: not reported in source
Isolated perfused rat submandibular glands
Comparator
VIP without antagonist
Outcome group
Gastrointestinal function · Gastrointestinal
Source sentences
Summary
a VIP antagonist blocked the VIP enhancement of saliva volume but not the increase in protein.
1 context sentence(design, population, supporting numbers)
Summary · context
The isolated, perfused gland was used to examine the regulation of saliva volume and protein content by vasoactive intestinal peptide (VIP).
In this study, Vasoactive intestinal peptide (VIP, aviptadil) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Vasoactive intestinal peptide (VIP, aviptadil).
Report a problemFND-0138157712

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
12 Oct 2026, 12:58 UTC
Study results updated
Version 1
9 Oct 2026, 12:41 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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