In rat IEC-6 cells, Des-(1-3)-IGF-I had 10-fold greater proliferation potency than IGF-I.
In plain wordsIn cells, Des-(1-3)-IGF-I promoted proliferation more potently than IGF-I.
- Peptide
- IGF-1 DES (des(1-3)IGF-I)
- Outcome
- IncreaseCell proliferation potency
- Study
ratn: not reported in source
IEC-6 intestinal epithelial cells- Comparator
- IGF-I
- Outcome group
- Receptor activity and mechanism · Gastrointestinal
- Studied dose
- Dose not stated
Measurements
- Relative potency
- 10 fold
- versus IGF-I
Source sentences
Both analogs exhibited 10-fold greater potency than IGF-I, presumably because endogenously secreted IGFBPs depress IGF-I binding to cell surface receptors.
1 context sentence(design, population, supporting numbers)
To determine if IGFBP-2 modulates IGF responses in IEC-6 cells, the IGF-I analogs, Des-(1-3)-IGF-I and [Gln3,Ala4,Tyr15,Leu16]IGF-I, both of which have a reduced affinity for IGFBPs, were tested for their effects on IEC-6 cell proliferation.