Skip to content

Study · In vitro (cells) · 1992

6 results

Insulin and insulin-like growth factors (IGFs) stimulate production of IGF-binding proteins by ovarian granulosa cells.

Grimes RW, Hammond JM

Endocrinology1 Aug 1992Cited by 37 (Europe PMC)

PMID1379161 (opens in a new tab)DOI10.1210/endo.131.2.1379161 (opens in a new tab)PepBankPUB-01379161
Publisher pagePubMedAsk about this study
Jump to 6 results

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

4 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Mechanism

    In ovarian granulosa cell cultures, long R3-IGF-I was significantly more potent than IGF-I in stimulating IGFBP-3 production.

    In plain wordsIn cultured ovarian cells, long R3-IGF-I stimulated IGFBP-3 production more strongly than IGF-I.

    Peptide
    IGF-1 LR3
    Outcome
    IncreaseIGFBP-3 production relative to IGF-I
    Study

    n: not reported in source

    Ovarian granulosa cell cultures
    Comparator
    IGF-I
    Outcome group
    Growth hormone and IGF-1 · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The synthetic IGF, long R3-IGF-I, which has very low affinity for IGFBPs and only slightly reduced affinity for the IGF-I (type I) receptor, had significantly greater potency in stimulating IGFBP-3 and -2 production compared to IGF-I.
    1 context sentence
    Summary · context
    Ligand blot analysis of granulosa cell (GC)-conditioned culture medium revealed several easily measurable insulin-like growth factor (IGF)-binding proteins (IGFBPs), including IGFBP-3 [40-44 kilodaltons (kDa)] and IGFBP-2 (34 kDa).
  2. 02LabIn vitro (cells)Mechanism

    In ovarian granulosa cell cultures, long R3-IGF-I was significantly more potent than IGF-I in stimulating IGFBP-2 production.

    In plain wordsIn cultured ovarian cells, long R3-IGF-I stimulated IGFBP-2 production more strongly than IGF-I.

    Peptide
    IGF-1 LR3
    Outcome
    IncreaseIGFBP-2 production relative to IGF-I
    Study

    n: not reported in source

    Ovarian granulosa cell cultures
    Comparator
    IGF-I
    Outcome group
    Growth hormone and IGF-1 · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The synthetic IGF, long R3-IGF-I, which has very low affinity for IGFBPs and only slightly reduced affinity for the IGF-I (type I) receptor, had significantly greater potency in stimulating IGFBP-3 and -2 production compared to IGF-I.
    1 context sentence
    Summary · context
    Ligand blot analysis of granulosa cell (GC)-conditioned culture medium revealed several easily measurable insulin-like growth factor (IGF)-binding proteins (IGFBPs), including IGFBP-3 [40-44 kilodaltons (kDa)] and IGFBP-2 (34 kDa).
  3. 03LabIn vitro (cells)Activity measurement

    In granulosa cell cultures, des-(1-3)-IGF-I had similar effects to long R3-IGF-I, which stimulated IGFBP-3 production more potently than IGF-I.

    In plain wordsIn cells, des-(1-3)-IGF-I stimulated IGFBP-3 production similarly to long R3-IGF-I, which was more potent than IGF-I.

    Peptide
    IGF-1 DES (des(1-3)IGF-I)
    Outcome
    IncreaseIGFBP-3 production potency
    Study

    n: not reported in source

    ovarian granulosa cell cultures
    Comparator
    IGF-I
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Des-(1-3)-IGF-I had similar effects.
    2 context sentences
    Summary · context
    The synthetic IGF, long R3-IGF-I, which has very low affinity for IGFBPs and only slightly reduced affinity for the IGF-I (type I) receptor, had significantly greater potency in stimulating IGFBP-3 and -2 production compared to IGF-I.
    Summary · context
    Ligand blot analysis of granulosa cell (GC)-conditioned culture medium revealed several easily measurable insulin-like growth factor (IGF)-binding proteins (IGFBPs), including IGFBP-3 [40-44 kilodaltons (kDa)] and IGFBP-2 (34 kDa).
  4. 04LabIn vitro (cells)Activity measurement

    In granulosa cell cultures, des-(1-3)-IGF-I had similar effects to long R3-IGF-I, which stimulated IGFBP-2 production more potently than IGF-I.

    In plain wordsIn cells, des-(1-3)-IGF-I stimulated IGFBP-2 production similarly to long R3-IGF-I, which was more potent than IGF-I.

    Peptide
    IGF-1 DES (des(1-3)IGF-I)
    Outcome
    IncreaseIGFBP-2 production potency
    Study

    n: not reported in source

    ovarian granulosa cell cultures
    Comparator
    IGF-I
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Des-(1-3)-IGF-I had similar effects.
    2 context sentences
    Summary · context
    The synthetic IGF, long R3-IGF-I, which has very low affinity for IGFBPs and only slightly reduced affinity for the IGF-I (type I) receptor, had significantly greater potency in stimulating IGFBP-3 and -2 production compared to IGF-I.
    Summary · context
    Ligand blot analysis of granulosa cell (GC)-conditioned culture medium revealed several easily measurable insulin-like growth factor (IGF)-binding proteins (IGFBPs), including IGFBP-3 [40-44 kilodaltons (kDa)] and IGFBP-2 (34 kDa).

Studies that did not test the peptide alone2

In this study, the peptide was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking the peptide.

  1. 05LabNot a test of IGF-1 LR3 aloneIn vitro (cells)Mechanism

    In ovarian granulosa cell cultures, IGF-I, IGF-II and the IGF-I analogs (including long R3-IGF-I), but not insulin, induced production of an unidentified 30-kDa IGFBP that is not normally detectable.

    In plain wordsIn cultured ovarian cells, IGF-I analogs including long R3-IGF-I induced an unidentified 30-kDa binding protein.

    Peptide
    IGF-1 LR3
    Outcome
    Increase30-kDa IGFBP induction
    Study

    n: not reported in source

    Ovarian granulosa cell cultures
    Outcome group
    Growth hormone and IGF-1 · Reproductive and sexual health

    Source sentences

    Summary
    IGF-I, IGF-II, and the IGF-I analogs, but not insulin, also induced production of an unidentified 30-kDa IGFBP not normally detectable in these cultures.
    1 context sentence
    Summary · context
    Ligand blot analysis of granulosa cell (GC)-conditioned culture medium revealed several easily measurable insulin-like growth factor (IGF)-binding proteins (IGFBPs), including IGFBP-3 [40-44 kilodaltons (kDa)] and IGFBP-2 (34 kDa).

    In this study, IGF-1 LR3 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking IGF-1 LR3.

  2. 06LabNot a test of IGF-1 DES (des(1-3)IGF-I) aloneIn vitro (cells)Activity measurement

    In granulosa cell cultures, IGF-I analogs including des-(1-3)-IGF-I induced production of a normally undetectable 30-kDa IGFBP.

    In plain wordsIn cells, pooled IGF-I analogs including des-(1-3)-IGF-I induced an IGF-binding protein that cultures normally did not produce.

    Peptide
    IGF-1 DES (des(1-3)IGF-I)
    Outcome
    IncreaseUnidentified 30-kDa IGFBP production
    Study

    n: not reported in source

    ovarian granulosa cell cultures
    Comparator
    Normally undetectable in cultures
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones

    Source sentences

    Summary
    IGF-I, IGF-II, and the IGF-I analogs, but not insulin, also induced production of an unidentified 30-kDa IGFBP not normally detectable in these cultures.
    1 context sentence
    Summary · context
    Ligand blot analysis of granulosa cell (GC)-conditioned culture medium revealed several easily measurable insulin-like growth factor (IGF)-binding proteins (IGFBPs), including IGFBP-3 [40-44 kilodaltons (kDa)] and IGFBP-2 (34 kDa).

    In this study, IGF-1 DES (des(1-3)IGF-I) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking IGF-1 DES (des(1-3)IGF-I).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Versions 3 to 4Current

    21 Oct 2026, 13:52 UTC

    The same notice was added 2 times, first on 21 Oct 2026, 12:50 UTC. The status did not change between them.

    Study data updated · source update from Europe PMC

  2. Version 2

    13 Oct 2026, 21:44 UTC

    Study results updated

  3. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

PepBank is a research reference. Talk to a doctor before you use any peptide.