Novel recombinant fusion protein analogues of insulin-like growth factor (IGF)-I indicate the relative importance of IGF-binding protein and receptor binding for enhanced biological potency.

Francis GL, Ross M, Ballard FJ, Milner SJ, Senn C, McNeil KA, Wallace JC, King R, Wells JR

Journal of molecular endocrinology1 Jun 1992Cited by 122 (Europe PMC)

PMID1378742DOI10.1677/jme.0.0080213PepBankPUB-01378742

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. No result from this study comes from people.

01LabIn vitro (cells)Activity measurement
In L6 rat myoblasts, des(1‑3)IGF-I stimulated protein synthesis more potently than authentic IGF-I.
In plain wordsIn cells, des(1‑3)IGF-I stimulated protein synthesis more potently than authentic IGF-I.
Peptide
IGF-1 DES (des(1-3)IGF-I)
Outcome
IncreaseProtein synthesis potency
Study
ratn: not reported in source
L6 myoblasts
Comparator
Authentic IGF-I
Outcome group
Muscle injury and repair · Musculoskeletal
Studied dose
Dose not stated
Source sentences
Summary
In L6 rat myoblasts, all the analogues were more potent than authentic IGF-I in their abilities to stimulate protein and DNA synthesis and inhibit protein breakdown.
1 context sentence(design, population, supporting numbers)
Summary · context
The biological activities of the IGF-I fusion peptides were compared with authentic IGF-I and the truncated analogue, des(1-3)IGF-I.
Report a problemFND-0137874201
02LabIn vitro (cells)Activity measurement
In L6 rat myoblasts, des(1‑3)IGF-I stimulated DNA synthesis more potently than authentic IGF-I.
In plain wordsIn cells, des(1‑3)IGF-I stimulated DNA synthesis more potently than authentic IGF-I.
Peptide
IGF-1 DES (des(1-3)IGF-I)
Outcome
IncreaseDNA synthesis potency
Study
ratn: not reported in source
L6 myoblasts
Comparator
Authentic IGF-I
Outcome group
Muscle injury and repair · Musculoskeletal
Studied dose
Dose not stated
Source sentences
Summary
In L6 rat myoblasts, all the analogues were more potent than authentic IGF-I in their abilities to stimulate protein and DNA synthesis and inhibit protein breakdown.
1 context sentence(design, population, supporting numbers)
Summary · context
The biological activities of the IGF-I fusion peptides were compared with authentic IGF-I and the truncated analogue, des(1-3)IGF-I.
Report a problemFND-0137874202
03LabIn vitro (cells)Activity measurement
In L6 rat myoblasts, des(1‑3)IGF-I inhibited protein breakdown more potently than authentic IGF-I.
In plain wordsIn cells, des(1‑3)IGF-I inhibited protein breakdown more potently than authentic IGF-I.
Peptide
IGF-1 DES (des(1-3)IGF-I)
Outcome
IncreaseProtein breakdown inhibition potency
Study
ratn: not reported in source
L6 myoblasts
Comparator
Authentic IGF-I
Outcome group
Muscle injury and repair · Musculoskeletal
Studied dose
Dose not stated
Source sentences
Summary
In L6 rat myoblasts, all the analogues were more potent than authentic IGF-I in their abilities to stimulate protein and DNA synthesis and inhibit protein breakdown.
1 context sentence(design, population, supporting numbers)
Summary · context
The biological activities of the IGF-I fusion peptides were compared with authentic IGF-I and the truncated analogue, des(1-3)IGF-I.
Report a problemFND-0137874203
04LabIn vitro (cells)Activity measurement
In IGFBP-secreting cells, des(1‑3)IGF-I ranked with Long [Arg3]-IGF-I above Long [Gly3]-IGF-I, Long IGF-I and IGF-I.
In plain wordsIn cells, des(1‑3)IGF-I ranked with Long [Arg3]-IGF-I above the other tested IGFs.
Peptide
IGF-1 DES (des(1-3)IGF-I)
Outcome
MixedBiological potency ranking
Study
n: not reported in source
Cell lines secreting IGFBPs
Comparator
Long IGF-I analogues and IGF-I
Outcome group
Muscle injury and repair · Musculoskeletal
Studied dose
Dose not stated
Source sentences
Summary
The order of biological potency in cell lines secreting IGF-binding proteins (IGFBPs) into the medium was Long [Arg3]-IGF-I-des(1-3)IGF-I greater than Long [Gly3]-IGF-I greater than Long IGF-I greater than IGF-I.
1 context sentence(design, population, supporting numbers)
Summary · context
The biological activities of the IGF-I fusion peptides were compared with authentic IGF-I and the truncated analogue, des(1-3)IGF-I.
Report a problemFND-0137874204

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 4Current
21 Oct 2026, 15:58 UTC
Study results updated
Versions 2 to 3
21 Oct 2026, 13:52 UTC
The same notice was added 2 times, first on 21 Oct 2026, 12:50 UTC. The status did not change between them.
Study data updated · source update from Europe PMC
Version 1
13 Oct 2026, 16:31 UTC
First added · source update from Europe PMC

Novel recombinant fusion protein analogues of insulin-like growth factor (IGF)-I indicate the relative importance of IGF-binding protein and receptor binding for enhanced biological potency.

Summary

Results from this study4

Version history

Subjects

Publication types

MeSH terms