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Study · In vitro (cells) · 1992

2 results

Sensitive colorimetric bioassays for insulin-like growth factor (IGF) stimulation of cell proliferation and glucose consumption: use in studies of IGF analogs.

Okajima T, Nakamura K, Zhang H, Ling N, Tanabe T, Yasuda T, Rosenfeld RG

Endocrinology1 Apr 1992Cited by 64 (Europe PMC)

PMID1372238 (opens in a new tab)DOI10.1210/endo.130.4.1372238 (opens in a new tab)PepBankPUB-01372238
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Activity measurement

    In BALB/c 3T3 fibroblast assays, des(1‑3)-IGF-I demonstrated mitogenic activity equivalent to IGF-I.

    In plain wordsIn cells, des(1‑3)-IGF-I showed mitogenic activity equivalent to IGF-I.

    Peptide
    IGF-1 DES (des(1-3)IGF-I)
    Outcome
    No significant changeMitogenic bioactivity
    Study

    n: not reported in source

    BALB/c 3T3 fibroblasts
    Comparator
    IGF-I
    Outcome group
    Receptor activity and mechanism · Pharmacology
    Studied dose
    Dose not stated

    Source sentences

    Summary
    When these assays were used to measure the bioactivity of IGF analogs, a des(1-3)-IGF-I, which has decreased affinity for IGF binding proteins, demonstrated activity equivalent to IGF-I,
    2 context sentences
    Summary · context
    The first assay was used to quantitate mitogenic activity and the second was used to quantitate metabolic activity.
    Summary · context
    Both assays use BALB/c 3T3 fibroblasts grown under serum-free conditions; detection of bioactivity in assays was performed colorimetrically and did not require the use of radioisotopes.
  2. 02LabIn vitro (cells)Activity measurement

    In BALB/c 3T3 fibroblast assays, des(1‑3)-IGF-I demonstrated metabolic activity equivalent to IGF-I.

    In plain wordsIn cells, des(1‑3)-IGF-I showed metabolic activity equivalent to IGF-I.

    Peptide
    IGF-1 DES (des(1-3)IGF-I)
    Outcome
    No significant changeMetabolic bioactivity
    Study

    n: not reported in source

    BALB/c 3T3 fibroblasts
    Comparator
    IGF-I
    Outcome group
    Receptor activity and mechanism · Pharmacology
    Studied dose
    Dose not stated

    Source sentences

    Summary
    When these assays were used to measure the bioactivity of IGF analogs, a des(1-3)-IGF-I, which has decreased affinity for IGF binding proteins, demonstrated activity equivalent to IGF-I,
    2 context sentences
    Summary · context
    The first assay was used to quantitate mitogenic activity and the second was used to quantitate metabolic activity.
    Summary · context
    Both assays use BALB/c 3T3 fibroblasts grown under serum-free conditions; detection of bioactivity in assays was performed colorimetrically and did not require the use of radioisotopes.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 2

    21 Oct 2026, 13:52 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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