Amperozide and clozapine but not haloperidol or raclopride increase the secretion of oxytocin in rats.

Uvnäs-Moberg K, Alster P, Svensson TH

Psychopharmacology1 Jan 1992Cited by 52 (Europe PMC)

PMID1365865DOI10.1007/bf02247726PepBankPUB-01365865

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study8

No result from this study comes from a test of the peptide.

Natural levels measured8

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

01AnimalEndogenous levelAnimal study (in vivo)Mechanism
In rats, amperozide at 2.5 and 5 mg/kg raised plasma levels of the body's own oxytocin.
In plain wordsIn rats, the drug amperozide raised the body's own oxytocin levels in blood.
Peptide
Oxytocin
Outcome
IncreasePlasma oxytocin after amperozide
Study
ratn: not reported in source
Outcome group
Sex hormones and fertility · Endocrine and hormones
Source sentences
Summary
Amperozide 2.5 and 5 mg/kg increased plasma levels of oxytocin significantly (P < 0.05 and < 0.001).
1 context sentence(design, population, supporting numbers)
Summary · context
For this purpose, female or male Sprague Dawley rats were given amperozide (0.5, 2.5 and 5.0 mg/kg IP), ritanserin (5.0 mg/kg), raclopride (2.0 mg/kg) and prazosin (1.0 mg/kg) and were subsequently decapitated for collection of blood (30 and 120 min) after injection.
This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-0136586501
02AnimalEndogenous levelAnimal study (in vivo)Mechanism
In rats, the amperozide effect on the body's own oxytocin peaked about 30 min after injection and levels were almost back to basal within 120 min.
In plain wordsIn rats, amperozide raised the body's own oxytocin for a short time, with a peak near 30 minutes.
Peptide
Oxytocin
Outcome
IncreaseTime course of plasma oxytocin after amperozide
Study
ratn: not reported in source
Outcome group
Sex hormones and fertility · Endocrine and hormones
Measurements
Time of maximal effect
≈ 30 min
after amperozide injection
Time to near-basal oxytocin
≤ 120 min
after amperozide injection
Source sentences
Summary
The effect appeared maximal about 30 min after injection of the drug and oxytocin levels were almost back to basal within 120 min.
1 context sentence(design, population, supporting numbers)
Summary · context
For this purpose, female or male Sprague Dawley rats were given amperozide (0.5, 2.5 and 5.0 mg/kg IP), ritanserin (5.0 mg/kg), raclopride (2.0 mg/kg) and prazosin (1.0 mg/kg) and were subsequently decapitated for collection of blood (30 and 120 min) after injection.
This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-0136586502
03AnimalEndogenous levelAnimal study (in vivo)Mechanism
In rats, amperozide raised the body's own oxytocin similarly in female and male rats and in freely fed and food-deprived animals.
In plain wordsIn rats, amperozide raised the body's own oxytocin in both sexes and in fed and fasted animals.
Peptide
Oxytocin
Outcome
IncreasePlasma oxytocin by sex and feeding state
Study
ratn: not reported in source
Outcome group
Sex hormones and fertility · Endocrine and hormones
Source sentences
Summary
Similar effects were obtained in female and male rats as well as in animals that were freely fed or food deprived for 24 h.
1 context sentence(design, population, supporting numbers)
Summary · context
For this purpose, female or male Sprague Dawley rats were given amperozide (0.5, 2.5 and 5.0 mg/kg IP), ritanserin (5.0 mg/kg), raclopride (2.0 mg/kg) and prazosin (1.0 mg/kg) and were subsequently decapitated for collection of blood (30 and 120 min) after injection.
This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-0136586503
04AnimalEndogenous levelAnimal study (in vivo)Mechanism
In rats, amperozide also raised CSF levels of the body's own oxytocin.
In plain wordsIn rats, amperozide also raised the body's own oxytocin in spinal fluid.
Peptide
Oxytocin
Outcome
IncreaseCSF oxytocin after amperozide
Study
ratn: not reported in source
Outcome group
Sex hormones and fertility · Endocrine and hormones
Source sentences
Summary
CSF levels of oxytocin were also increased.
1 context sentence(design, population, supporting numbers)
Summary · context
For this purpose, female or male Sprague Dawley rats were given amperozide (0.5, 2.5 and 5.0 mg/kg IP), ritanserin (5.0 mg/kg), raclopride (2.0 mg/kg) and prazosin (1.0 mg/kg) and were subsequently decapitated for collection of blood (30 and 120 min) after injection.
This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-0136586504
05AnimalEndogenous levelAnimal study (in vivo)Mechanism
In rats, the 5-HT2 antagonist ritanserin stimulated release of the body's own oxytocin.
In plain wordsIn rats, the drug ritanserin made the body release more of its own oxytocin.
Peptide
Oxytocin
Outcome
IncreaseOxytocin release after ritanserin
Study
ratn: not reported in source
Outcome group
Sex hormones and fertility · Endocrine and hormones
Source sentences
Summary
Ritanserin, a 5-HT2-receptor antagonist but not the D2 receptor antagonist raclopride or the alpha 1-adrenoceptor antagonist prazosin stimulated oxytocin release.
1 context sentence(design, population, supporting numbers)
Summary · context
For this purpose, female or male Sprague Dawley rats were given amperozide (0.5, 2.5 and 5.0 mg/kg IP), ritanserin (5.0 mg/kg), raclopride (2.0 mg/kg) and prazosin (1.0 mg/kg) and were subsequently decapitated for collection of blood (30 and 120 min) after injection.
This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-0136586505
06AnimalEndogenous levelAnimal study (in vivo)Mechanism
In rats, the D2 antagonist raclopride and the alpha 1-adrenoceptor antagonist prazosin did not stimulate release of the body's own oxytocin.
In plain wordsIn rats, raclopride and prazosin did not change the body's own oxytocin release.
Peptide
Oxytocin
Outcome
No significant changeOxytocin release after raclopride or prazosin
Study
ratn: not reported in source
Outcome group
Sex hormones and fertility · Endocrine and hormones
Source sentences
Summary
Ritanserin, a 5-HT2-receptor antagonist but not the D2 receptor antagonist raclopride or the alpha 1-adrenoceptor antagonist prazosin stimulated oxytocin release.
1 context sentence(design, population, supporting numbers)
Summary · context
For this purpose, female or male Sprague Dawley rats were given amperozide (0.5, 2.5 and 5.0 mg/kg IP), ritanserin (5.0 mg/kg), raclopride (2.0 mg/kg) and prazosin (1.0 mg/kg) and were subsequently decapitated for collection of blood (30 and 120 min) after injection.
This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-0136586506
07AnimalEndogenous levelAnimal study (in vivo)Mechanism
In rats, clozapine was a potent releaser of the body's own oxytocin.
In plain wordsIn rats, the drug clozapine strongly raised the body's own oxytocin release.
Peptide
Oxytocin
Outcome
IncreaseOxytocin release after clozapine
Study
ratn: not reported in source
Outcome group
Sex hormones and fertility · Endocrine and hormones
Source sentences
Summary
In addition, clozapine, a neuroleptic with potent HT2-antagonistic properties, was a potent releaser of oxytocin, whereas haloperidol was without effect.
1 context sentence(design, population, supporting numbers)
Summary · context
For this purpose, female or male Sprague Dawley rats were given amperozide (0.5, 2.5 and 5.0 mg/kg IP), ritanserin (5.0 mg/kg), raclopride (2.0 mg/kg) and prazosin (1.0 mg/kg) and were subsequently decapitated for collection of blood (30 and 120 min) after injection.
This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-0136586507
08AnimalEndogenous levelAnimal study (in vivo)Mechanism
In rats, haloperidol did not affect release of the body's own oxytocin.
In plain wordsIn rats, haloperidol did not change the body's own oxytocin release.
Peptide
Oxytocin
Outcome
No significant changeOxytocin release after haloperidol
Study
ratn: not reported in source
Outcome group
Sex hormones and fertility · Endocrine and hormones
Source sentences
Summary
In addition, clozapine, a neuroleptic with potent HT2-antagonistic properties, was a potent releaser of oxytocin, whereas haloperidol was without effect.
1 context sentence(design, population, supporting numbers)
Summary · context
For this purpose, female or male Sprague Dawley rats were given amperozide (0.5, 2.5 and 5.0 mg/kg IP), ritanserin (5.0 mg/kg), raclopride (2.0 mg/kg) and prazosin (1.0 mg/kg) and were subsequently decapitated for collection of blood (30 and 120 min) after injection.
This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-0136586508

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Version 2Current
11 Oct 2026, 20:03 UTC
Study results updated
Version 1
9 Oct 2026, 02:51 UTC
First added · source update from Europe PMC

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