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Study · Ex vivo tissue · rat · 1992

4 results

Effect of thymosin alpha 1 on hypothalamic hormone release.

Milenkovic L, Lyson K, Aguila MC, McCann SM

Neuroendocrinology1 Nov 1992Cited by 9 (Europe PMC)

PMID1362597 (opens in a new tab)DOI10.1159/000126292 (opens in a new tab)PepBankPUB-01362597
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabEx vivo tissueEfficacy outcome

    In medial basal hypothalamic fragments incubated in vitro, thymosin alpha‑1 inhibited TRH release, with a minimal effective dose of 10(-11) M.

    In plain wordsIn lab tests on hypothalamus tissue, thymosin alpha‑1 reduced release of TRH.

    Peptide
    Thymosin alpha-1
    Outcome
    DecreaseTRH release from hypothalamic fragments
    Study

    ratn: not reported in source

    Medial basal hypothalamic fragments incubated in vitro
    Outcome group
    Hormone levels · Endocrine and hormones
    Studied dose
    minimal effective dose 10(-11) MAs given in this study (rat).

    Source sentences

    Summary
    T alpha 1 was shown to inhibit the release of TRH and CRH from MBH fragments incubated in vitro with a minimal effective dose (MED) of 10(-11) M.
    1 context sentence
    Summary · context
    Therefore, in the present study we evaluated the effect of the peptide on the release of hypothalamic regulatory hormones: thyrotropin-releasing hormone (TRH) and corticotropin-releasing hormone (CRH), as well as somatostatin (SRIH), from medial basal hypothalamic (MBH) fragments incubated in vitro.
  2. 02LabEx vivo tissueEfficacy outcome

    In medial basal hypothalamic fragments incubated in vitro, thymosin alpha‑1 inhibited CRH release.

    In plain wordsIn lab tests on hypothalamus tissue, thymosin alpha‑1 reduced release of CRH.

    Peptide
    Thymosin alpha-1
    Outcome
    DecreaseCRH release from hypothalamic fragments
    Study

    ratn: not reported in source

    Medial basal hypothalamic fragments incubated in vitro
    Outcome group
    Hormone levels · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    T alpha 1 was shown to inhibit the release of TRH and CRH from MBH fragments incubated in vitro with a minimal effective dose (MED) of 10(-11) M.
    1 context sentence
    Summary · context
    Therefore, in the present study we evaluated the effect of the peptide on the release of hypothalamic regulatory hormones: thyrotropin-releasing hormone (TRH) and corticotropin-releasing hormone (CRH), as well as somatostatin (SRIH), from medial basal hypothalamic (MBH) fragments incubated in vitro.
  3. 03LabEx vivo tissueEfficacy outcome

    In medial basal hypothalamic fragments incubated in vitro, thymosin alpha‑1 inhibited somatostatin release, with a minimal effective dose of 10(-9) M.

    In plain wordsIn lab tests on hypothalamus tissue, thymosin alpha‑1 reduced release of somatostatin.

    Peptide
    Thymosin alpha-1
    Outcome
    DecreaseSomatostatin (SRIH) release from hypothalamic fragments
    Study

    ratn: not reported in source

    Medial basal hypothalamic fragments incubated in vitro
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    minimal effective dose 10(-9) MAs given in this study (rat).

    Source sentences

    Summary
    SRIH and CRH release was also inhibited but the MED for these peptides was 10(-9) M.
    1 context sentence
    Summary · context
    Therefore, in the present study we evaluated the effect of the peptide on the release of hypothalamic regulatory hormones: thyrotropin-releasing hormone (TRH) and corticotropin-releasing hormone (CRH), as well as somatostatin (SRIH), from medial basal hypothalamic (MBH) fragments incubated in vitro.
  4. 04LabEx vivo tissueActivity measurement

    In hypothalamic fragments in vitro, the response to thymosin alpha‑1 was largest for TRH, then CRH, then SRIH.

    In plain wordsIn lab tests on hypothalamus tissue, thymosin alpha‑1 acted most strongly on TRH, then CRH, then somatostatin.

    Peptide
    Thymosin alpha-1
    Outcome
    Not applicableRelative responsiveness of TRH, CRH and SRIH release
    Study

    ratn: not reported in source

    Medial basal hypothalamic fragments incubated in vitro
    Outcome group
    Hormone levels · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The relative responsiveness to the action of T alpha 1 was TRH greater than CRH, which was greater than SRIH.
    1 context sentence
    Summary · context
    Therefore, in the present study we evaluated the effect of the peptide on the release of hypothalamic regulatory hormones: thyrotropin-releasing hormone (TRH) and corticotropin-releasing hormone (CRH), as well as somatostatin (SRIH), from medial basal hypothalamic (MBH) fragments incubated in vitro.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    10 Oct 2026, 08:55 UTC

    Study results updated

  2. Version 2

    9 Oct 2026, 03:03 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    9 Oct 2026, 03:02 UTC

    First added · source update from Europe PMC

Subjects

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