The effects of sandostatin and somatostatin on nociceptive transmission in the dorsal horn of the rat spinal cord.

Chapman V, Dickenson AH

Neuropeptides1 Nov 1992Cited by 55 (Europe PMC)

PMID1361670DOI10.1016/0143-4179(92)90115-dPepBankPUB-01361670

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study11

11 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In rats, intrathecal sandostatin did not alter the C-fibre response.
In plain wordsIn rats, intrathecal sandostatin did not change the C-fibre response.
Peptide
Octreotide
Outcome
No significant changeC-fibre response
Study
ratn: not reported in source
Spinal neuronal responses to electrical stimulation or formalin
Outcome group
Pain · Nervous system and cognition
Studied dose
Dose not stated · intrathecalAs given in this study (rat).
Source sentences
Summary
Intrathecal pre-treatment with sandostatin and somatostatin did not alter the C-fibre response, wind up or A beta responses of the cells.
2 context sentences(design, population, supporting numbers)
Summary · context
The role of somatostatin and a stable analogue, sandostatin (Octreotide), on the responses of spinal cord neurones in vivo was investigated in the rat.
Summary · context
Electrical C-fibre stimulation was used as a model of acute nociception and the response to subcutaneous formalin was used as a model of longer term events.
Report a problemFND-0136167001
02AnimalAnimal study (in vivo)Efficacy outcome
In rats, intrathecal sandostatin did not alter neuronal wind up.
In plain wordsIn rats, intrathecal sandostatin did not change neuronal wind up.
Peptide
Octreotide
Outcome
No significant changeWind up
Study
ratn: not reported in source
Spinal neuronal responses to electrical stimulation or formalin
Outcome group
Pain · Nervous system and cognition
Studied dose
Dose not stated · intrathecalAs given in this study (rat).
Source sentences
Summary
Intrathecal pre-treatment with sandostatin and somatostatin did not alter the C-fibre response, wind up or A beta responses of the cells.
2 context sentences(design, population, supporting numbers)
Summary · context
The role of somatostatin and a stable analogue, sandostatin (Octreotide), on the responses of spinal cord neurones in vivo was investigated in the rat.
Summary · context
Electrical C-fibre stimulation was used as a model of acute nociception and the response to subcutaneous formalin was used as a model of longer term events.
Report a problemFND-0136167002
03AnimalAnimal study (in vivo)Efficacy outcome
In rats, intrathecal sandostatin did not alter A beta responses.
In plain wordsIn rats, intrathecal sandostatin did not change A beta responses.
Peptide
Octreotide
Outcome
No significant changeA beta responses
Study
ratn: not reported in source
Spinal neuronal responses to electrical stimulation or formalin
Outcome group
Pain · Nervous system and cognition
Studied dose
Dose not stated · intrathecalAs given in this study (rat).
Source sentences
Summary
Intrathecal pre-treatment with sandostatin and somatostatin did not alter the C-fibre response, wind up or A beta responses of the cells.
2 context sentences(design, population, supporting numbers)
Summary · context
The role of somatostatin and a stable analogue, sandostatin (Octreotide), on the responses of spinal cord neurones in vivo was investigated in the rat.
Summary · context
Electrical C-fibre stimulation was used as a model of acute nociception and the response to subcutaneous formalin was used as a model of longer term events.
Report a problemFND-0136167003
04AnimalAnimal study (in vivo)Efficacy outcome
In rats, intrathecal sandostatin inhibited the first formalin response phase by 66 +/- 12%, with dose-dependent inhibition.
In plain wordsIn rats, intrathecal sandostatin inhibited the first phase of the formalin response.
Peptide
Octreotide
Outcome
DecreaseFirst formalin response phase
Study
ratn: not reported in source
Spinal neuronal responses to electrical stimulation or formalin
Outcome group
Pain · Nervous system and cognition
Studied dose
20 micrograms · intrathecalAs given in this study (rat).
Source sentences
Summary
Thus, sandostatin (20 micrograms) and somatostatin (150 micrograms) inhibited the first phase (66 +/- 12% inhibition and 52 +/- 13% respectively) and second phase (91 +/- 2% inhibition and 39 +/- 16% inhibition respectively).
3 context sentences(design, population, supporting numbers)
Summary · context
However, intrathecal pre-treatment with sandostatin and somatostatin inhibited both the first and second phases of the formalin response dose dependently.
Summary · context
The role of somatostatin and a stable analogue, sandostatin (Octreotide), on the responses of spinal cord neurones in vivo was investigated in the rat.
Summary · context
Electrical C-fibre stimulation was used as a model of acute nociception and the response to subcutaneous formalin was used as a model of longer term events.
Report a problemFND-0136167004
05AnimalAnimal study (in vivo)Efficacy outcome
In rats, intrathecal sandostatin inhibited the second formalin response phase by 91 +/- 2%, with dose-dependent inhibition.
In plain wordsIn rats, intrathecal sandostatin inhibited the second phase of the formalin response.
Peptide
Octreotide
Outcome
DecreaseSecond formalin response phase
Study
ratn: not reported in source
Spinal neuronal responses to electrical stimulation or formalin
Outcome group
Pain · Nervous system and cognition
Studied dose
20 micrograms · intrathecalAs given in this study (rat).
Source sentences
Summary
Thus, sandostatin (20 micrograms) and somatostatin (150 micrograms) inhibited the first phase (66 +/- 12% inhibition and 52 +/- 13% respectively) and second phase (91 +/- 2% inhibition and 39 +/- 16% inhibition respectively).
3 context sentences(design, population, supporting numbers)
Summary · context
However, intrathecal pre-treatment with sandostatin and somatostatin inhibited both the first and second phases of the formalin response dose dependently.
Summary · context
The role of somatostatin and a stable analogue, sandostatin (Octreotide), on the responses of spinal cord neurones in vivo was investigated in the rat.
Summary · context
Electrical C-fibre stimulation was used as a model of acute nociception and the response to subcutaneous formalin was used as a model of longer term events.
Report a problemFND-0136167005
06AnimalAnimal study (in vivo)Efficacy outcome
In rats, the second formalin response phase was more sensitive to sandostatin than the first phase.
In plain wordsIn rats, the second formalin response phase was more sensitive to sandostatin than the first phase.
Peptide
Octreotide
Outcome
IncreasePhase sensitivity
Study
ratn: not reported in source
Spinal neuronal responses to electrical stimulation or formalin
Comparator
First phase
Outcome group
Pain · Nervous system and cognition
Studied dose
Dose not stated · intrathecalAs given in this study (rat).
Source sentences
Summary
The second phase of the formalin response was more sensitive to somatostatin and sandostatin than the first.
2 context sentences(design, population, supporting numbers)
Summary · context
The role of somatostatin and a stable analogue, sandostatin (Octreotide), on the responses of spinal cord neurones in vivo was investigated in the rat.
Summary · context
Electrical C-fibre stimulation was used as a model of acute nociception and the response to subcutaneous formalin was used as a model of longer term events.
Report a problemFND-0136167006
07AnimalAnimal study (in vivo)Efficacy outcome
In rats, sandostatin was approximately 400 times more potent than somatostatin on the second formalin response phase.
In plain wordsIn rats, sandostatin was approximately 400 times more potent than somatostatin on the second formalin response phase.
Peptide
Octreotide
Outcome
IncreasePotency on second formalin phase
Study
ratn: not reported in source
Spinal neuronal responses to electrical stimulation or formalin
Comparator
Somatostatin
Outcome group
Pain · Nervous system and cognition
Studied dose
Dose not stated · intrathecalAs given in this study (rat).
Source sentences
Summary
Sandostatin was approximately 400 times more potent than somatostatin on the second phase of the response.
2 context sentences(design, population, supporting numbers)
Summary · context
The role of somatostatin and a stable analogue, sandostatin (Octreotide), on the responses of spinal cord neurones in vivo was investigated in the rat.
Summary · context
Electrical C-fibre stimulation was used as a model of acute nociception and the response to subcutaneous formalin was used as a model of longer term events.
Report a problemFND-0136167007
08AnimalAnimal study (in vivo)Efficacy outcome
In rats, subcutaneous sandostatin significantly inhibited the first formalin response phase.
In plain wordsIn rats, subcutaneous sandostatin inhibited the first formalin response phase.
Peptide
Octreotide
Outcome
DecreaseFirst formalin phase after subcutaneous dosing
Study
ratn: not reported in source
Spinal neuronal responses to electrical stimulation or formalin
Outcome group
Pain · Nervous system and cognition
Studied dose
100 mg/kg · subcutaneousAs given in this study (rat).
Source sentences
Summary
Subcutaneous sandostatin (100 mg/kg) significantly inhibited both the first and second phase of the formalin response whereas the local peripheral administration of sandostatin (20 micrograms) only inhibited the second phase of the formalin response.
2 context sentences(design, population, supporting numbers)
Summary · context
The role of somatostatin and a stable analogue, sandostatin (Octreotide), on the responses of spinal cord neurones in vivo was investigated in the rat.
Summary · context
Electrical C-fibre stimulation was used as a model of acute nociception and the response to subcutaneous formalin was used as a model of longer term events.
Report a problemFND-0136167008
09AnimalAnimal study (in vivo)Efficacy outcome
In rats, subcutaneous sandostatin significantly inhibited the second formalin response phase.
In plain wordsIn rats, subcutaneous sandostatin inhibited the second formalin response phase.
Peptide
Octreotide
Outcome
DecreaseSecond formalin phase after subcutaneous dosing
Study
ratn: not reported in source
Spinal neuronal responses to electrical stimulation or formalin
Outcome group
Pain · Nervous system and cognition
Studied dose
100 mg/kg · subcutaneousAs given in this study (rat).
Source sentences
Summary
Subcutaneous sandostatin (100 mg/kg) significantly inhibited both the first and second phase of the formalin response whereas the local peripheral administration of sandostatin (20 micrograms) only inhibited the second phase of the formalin response.
2 context sentences(design, population, supporting numbers)
Summary · context
The role of somatostatin and a stable analogue, sandostatin (Octreotide), on the responses of spinal cord neurones in vivo was investigated in the rat.
Summary · context
Electrical C-fibre stimulation was used as a model of acute nociception and the response to subcutaneous formalin was used as a model of longer term events.
Report a problemFND-0136167009
10AnimalAnimal study (in vivo)Efficacy outcome
In rats, local peripheral sandostatin did not inhibit the first formalin response phase.
In plain wordsIn rats, local peripheral sandostatin did not inhibit the first formalin response phase.
Peptide
Octreotide
Outcome
No significant changeFirst formalin phase after peripheral dosing
Study
ratn: not reported in source
Spinal neuronal responses to electrical stimulation or formalin
Outcome group
Pain · Nervous system and cognition
Studied dose
20 micrograms · local peripheralAs given in this study (rat).
Source sentences
Summary
Subcutaneous sandostatin (100 mg/kg) significantly inhibited both the first and second phase of the formalin response whereas the local peripheral administration of sandostatin (20 micrograms) only inhibited the second phase of the formalin response.
2 context sentences(design, population, supporting numbers)
Summary · context
The role of somatostatin and a stable analogue, sandostatin (Octreotide), on the responses of spinal cord neurones in vivo was investigated in the rat.
Summary · context
Electrical C-fibre stimulation was used as a model of acute nociception and the response to subcutaneous formalin was used as a model of longer term events.
Report a problemFND-0136167010
11AnimalAnimal study (in vivo)Efficacy outcome
In rats, local peripheral sandostatin inhibited the second formalin response phase.
In plain wordsIn rats, local peripheral sandostatin inhibited the second formalin response phase.
Peptide
Octreotide
Outcome
DecreaseSecond formalin phase after peripheral dosing
Study
ratn: not reported in source
Spinal neuronal responses to electrical stimulation or formalin
Outcome group
Pain · Nervous system and cognition
Studied dose
20 micrograms · local peripheralAs given in this study (rat).
Source sentences
Summary
Subcutaneous sandostatin (100 mg/kg) significantly inhibited both the first and second phase of the formalin response whereas the local peripheral administration of sandostatin (20 micrograms) only inhibited the second phase of the formalin response.
2 context sentences(design, population, supporting numbers)
Summary · context
The role of somatostatin and a stable analogue, sandostatin (Octreotide), on the responses of spinal cord neurones in vivo was investigated in the rat.
Summary · context
Electrical C-fibre stimulation was used as a model of acute nociception and the response to subcutaneous formalin was used as a model of longer term events.
Report a problemFND-0136167011

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
28 Oct 2026, 02:03 UTC
Study results updated
Version 1
27 Oct 2026, 16:36 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

MeSH terms

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