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Study · Animal study (in vivo) · fish and rat · 1992

3 results

[The mechanism of the intranasal action of dermorphin in representatives of 2 classes of vertebrates].

Chernova LS, Kamenskiĭ AA, Maliukina GA, Baturina EIu, Deĭgin VI, Iarova EP

Zhurnal evoliutsionnoi biokhimii i fiziologii1 Jan 1992Cited by 2 (Europe PMC)

PMID1355940 (opens in a new tab)PepBankPUB-01355940
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In fish, intranasal dermorphin induced effective analgesia.

    In plain wordsIn fish, dermorphin given through the nose produced pain relief.

    Peptide
    Dermorphin
    Outcome
    IncreaseAnalgesia in fish
    Study

    fishn: not reported in source

    Fish
    Outcome group
    Pain · Nervous system and cognition
    Studied dose
    0.02-0.20 mg/kg · intranasalAs given in this study (fish).

    Source sentences

    Summary
    It has been shown that endogenous opioid dermorphin induces effective analgesia after intranasal injection to fish (0.02-0.20 mg/kg) and rats (0.005 mg/kg).
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In rats, intranasal dermorphin induced effective analgesia.

    In plain wordsIn rats, dermorphin given through the nose produced pain relief.

    Peptide
    Dermorphin
    Outcome
    IncreaseAnalgesia in rats
    Study

    ratn: not reported in source

    Rats
    Outcome group
    Pain · Nervous system and cognition
    Studied dose
    0.005 mg/kg · intranasalAs given in this study (rat).

    Source sentences

    Summary
    It has been shown that endogenous opioid dermorphin induces effective analgesia after intranasal injection to fish (0.02-0.20 mg/kg) and rats (0.005 mg/kg).
  3. 03AnimalAnimal study (in vivo)Mechanism

    In the studied vertebrates, dermorphin analgesia persisted after olfactory and trigeminal denervation.

    In plain wordsIn the studied animals, dermorphin pain relief persisted after olfactory and trigeminal nerve denervation.

    Peptide
    Dermorphin
    Outcome
    Not applicableAnalgesia after denervation
    Study

    n: not reported in source

    Olfactory and trigeminal denervation
    Outcome group
    Pain · Nervous system and cognition
    Studied dose
    Dose not stated · intranasalAs given in this study.

    Source sentences

    Summary
    Maintenance of dermorphin analgesia after olfactory and trigeminal denervation indicates that the analgetic effect is not realized via the olfactory receptors or free terminals of the trigeminal nerve.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    27 Oct 2026, 18:20 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:32 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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