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Study · Ex vivo tissue · rat · 1992

8 results

Delta-sleep-inducing peptide stimulates melatonin, 5-methoxytryptophol and serotonin secretion from perifused rat pineal glands.

Ouichou A, Zitouni M, Raynaud F, Simonneaux V, Gharib A, Pévet P

Biological signals1 Mar 1992Cited by 8 (Europe PMC)

PMID1339175 (opens in a new tab)DOI10.1159/000109312 (opens in a new tab)PepBankPUB-01339175
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study8

8 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabEx vivo tissueEfficacy outcome

    In perifused rat pineal glands, DSIP stimulated melatonin synthesis and release.

    In plain wordsIn rat pineal glands in the lab, DSIP increased melatonin production and release.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    IncreaseMelatonin synthesis and release
    Study

    ratn: not reported in source

    perifused pineal glands
    Outcome group
    Hormone levels · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    DSIP stimulated melatonin (MEL), 5-methoxytryptophol (5-ML) and serotonin (5-HT) synthesis and release, whereas it did not affect pineal cyclic AMP levels.
  2. 02LabEx vivo tissueEfficacy outcome

    In perifused rat pineal glands, DSIP stimulated 5-methoxytryptophol synthesis and release.

    In plain wordsIn rat pineal glands in the lab, DSIP increased production and release of 5-methoxytryptophol.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    Increase5-methoxytryptophol synthesis and release
    Study

    ratn: not reported in source

    perifused pineal glands
    Outcome group
    Hormone levels · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    DSIP stimulated melatonin (MEL), 5-methoxytryptophol (5-ML) and serotonin (5-HT) synthesis and release, whereas it did not affect pineal cyclic AMP levels.
  3. 03LabEx vivo tissueEfficacy outcome

    In perifused rat pineal glands, DSIP stimulated serotonin synthesis and release.

    In plain wordsIn rat pineal glands in the lab, DSIP increased serotonin production and release.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    IncreaseSerotonin synthesis and release
    Study

    ratn: not reported in source

    perifused pineal glands
    Outcome group
    Hormone levels · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    DSIP stimulated melatonin (MEL), 5-methoxytryptophol (5-ML) and serotonin (5-HT) synthesis and release, whereas it did not affect pineal cyclic AMP levels.
  4. 04LabEx vivo tissueEfficacy outcome

    In perifused rat pineal glands, DSIP did not affect pineal cyclic AMP levels.

    In plain wordsIn rat pineal glands in the lab, DSIP did not change cyclic AMP levels.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    No significant changePineal cyclic AMP
    Study

    ratn: not reported in source

    perifused pineal glands
    Outcome group
    Hormone levels · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    DSIP stimulated melatonin (MEL), 5-methoxytryptophol (5-ML) and serotonin (5-HT) synthesis and release, whereas it did not affect pineal cyclic AMP levels.
  5. 05LabEx vivo tissueEfficacy outcome

    In perifused rat pineal glands, the stimulatory effect of DSIP on melatonin secretion was dose dependent, and the minimal effective concentration for 5-methoxytryptophol secretion was higher than 10(-5) M.

    In plain wordsIn rat pineal glands in the lab, higher DSIP doses gave more melatonin release.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    IncreaseDose dependence of melatonin secretion
    Study

    ratn: not reported in source

    perifused pineal glands
    Outcome group
    Hormone levels · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The stimulatory effect of DSIP on MEL secretion was dose dependent between 5 x 10(-6) and 10(-4) M, whereas the minimal effective concentration of DSIP on 5-ML secretion was higher than 10(-5) M.
  6. 06LabEx vivo tissuePharmacokinetics

    In perifused rat pineal glands, the effect of DSIP on melatonin release was faster and of shorter duration than the effect of isoproterenol.

    In plain wordsIn rat pineal glands in the lab, DSIP raised melatonin faster and for a shorter time than isoproterenol did.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    MixedKinetics of melatonin release versus isoproterenol
    Study

    ratn: not reported in source

    perifused pineal glands
    Comparator
    Isoproterenol
    Outcome group
    Hormone levels · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    With regard to kinetic characteristics, the effect of DSIP (10(-4) M) on MEL release was faster and of shorter duration than the effect of ISO (10(-6) M; 2 and 4 h, respectively).
  7. 07LabEx vivo tissueEfficacy outcome

    In perifused rat pineal glands, DSIP at 10(-4) M potentiated the isoproterenol-induced increase of melatonin secretion.

    In plain wordsIn rat pineal glands in the lab, DSIP made the melatonin rise caused by isoproterenol larger.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    IncreaseIsoproterenol-induced melatonin secretion with DSIP
    Study

    ratn: not reported in source

    perifused pineal glands
    Comparator
    Isoproterenol alone
    Outcome group
    Hormone levels · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    At 10(-4) M, DSIP potentiated the ISO-induced increase of MEL secretion.
  8. 08LabEx vivo tissueMechanism

    In perifused rat pineal glands, DSIP-stimulated melatonin release was not significantly altered by propranolol, prazosin or naloxone.

    In plain wordsIn rat pineal glands in the lab, blocking adrenaline-type or opioid receptors did not change the melatonin release caused by DSIP.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    No significant changeDSIP-stimulated melatonin release with adrenergic and opioid antagonists
    Study

    ratn: not reported in source

    perifused pineal glands
    Outcome group
    Hormone levels · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The DSIP-stimulated release of MEL was not significantly altered when the pineal glands were treated with 10(-5) M propranolol (a beta-adrenergic antagonist), 10(-5) M prazosin (an alpha 1-adrenergic antagonist) or 10(-5) M naloxone (an opioidergic antagonist).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 08:55 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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