Differential effect of arachidonic acid on the vasoactive intestinal peptide receptor/effector system in rat prostatic epithelium during sexual maturation.

Carmena MJ, Hueso C, Solano RM, Prieto JC

Peptides1 Nov 1992Cited by 5 (Europe PMC)

PMID1337377DOI10.1016/0196-9781(92)90016-vPepBankPUB-01337377

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone6

In this study, Vasoactive intestinal peptide (VIP, aviptadil) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Vasoactive intestinal peptide (VIP, aviptadil).

01LabNot a test of Vasoactive intestinal peptide (VIP, aviptadil) aloneIn vitro (cells)Efficacy outcome
In prostatic epithelial cells from mature rats, treatment with 0.1 mM arachidonic acid increased the affinity of VIP receptors.
In plain wordsIn cells from mature rat prostate, arachidonic acid made VIP receptors bind VIP more tightly.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
IncreaseVIP receptor affinity after arachidonic acid in mature rat cells
Study
ratn: not reported in source
Prostatic epithelial cells from pubertal and mature rats
Comparator
Cells without arachidonic acid treatment
Outcome group
Receptor activity and mechanism · Reproductive and sexual health
Source sentences
Summary
Treating cells with 0.1 mM arachidonic acid for 15 min at 37 degrees C increased the affinity of VIP receptors
2 context sentences(design, population, supporting numbers)
Summary · context
at maturity
Summary · context
prostatic epithelial cells from rats at puberty and maturity
In this study, Vasoactive intestinal peptide (VIP, aviptadil) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Vasoactive intestinal peptide (VIP, aviptadil).
Report a problemFND-0133737701
02LabNot a test of Vasoactive intestinal peptide (VIP, aviptadil) aloneIn vitro (cells)Efficacy outcome
In prostatic epithelial cells from pubertal rats, treatment with 0.1 mM arachidonic acid did not increase the affinity of VIP receptors.
In plain wordsIn cells from pubertal rat prostate, arachidonic acid did not change how tightly VIP receptors bind VIP.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
No significant changeVIP receptor affinity after arachidonic acid in pubertal rat cells
Study
ratn: not reported in source
Prostatic epithelial cells from pubertal and mature rats
Comparator
Cells without arachidonic acid treatment
Outcome group
Receptor activity and mechanism · Reproductive and sexual health
Source sentences
Summary
Treating cells with 0.1 mM arachidonic acid for 15 min at 37 degrees C increased the affinity of VIP receptors and the potency of the neuropeptide (up to five times) in the formation of cyclic AMP at maturity, but not at puberty.
1 context sentence(design, population, supporting numbers)
Summary · context
prostatic epithelial cells from rats at puberty and maturity
In this study, Vasoactive intestinal peptide (VIP, aviptadil) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Vasoactive intestinal peptide (VIP, aviptadil).
Report a problemFND-0133737702
03LabNot a test of Vasoactive intestinal peptide (VIP, aviptadil) aloneIn vitro (cells)Efficacy outcome
In prostatic epithelial cells from mature rats, arachidonic acid increased the potency of VIP in cyclic AMP formation by up to five times.
In plain wordsIn cells from mature rat prostate, arachidonic acid made VIP up to five times more potent at raising cyclic AMP.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
IncreasePotency of VIP in cyclic AMP formation after arachidonic acid in mature rat cells
Study
ratn: not reported in source
Prostatic epithelial cells from pubertal and mature rats
Comparator
Cells without arachidonic acid treatment
Outcome group
Receptor activity and mechanism · Reproductive and sexual health
Source sentences
Summary
Treating cells with 0.1 mM arachidonic acid for 15 min at 37 degrees C increased the affinity of VIP receptors and the potency of the neuropeptide (up to five times) in the formation of cyclic AMP at maturity, but not at puberty.
1 context sentence(design, population, supporting numbers)
Summary · context
prostatic epithelial cells from rats at puberty and maturity
In this study, Vasoactive intestinal peptide (VIP, aviptadil) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Vasoactive intestinal peptide (VIP, aviptadil).
Report a problemFND-0133737703
04LabNot a test of Vasoactive intestinal peptide (VIP, aviptadil) aloneIn vitro (cells)Efficacy outcome
In prostatic epithelial cells from pubertal rats, arachidonic acid did not increase the potency of VIP in cyclic AMP formation.
In plain wordsIn cells from pubertal rat prostate, arachidonic acid did not change how strongly VIP raised cyclic AMP.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
No significant changePotency of VIP in cyclic AMP formation after arachidonic acid in pubertal rat cells
Study
ratn: not reported in source
Prostatic epithelial cells from pubertal and mature rats
Comparator
Cells without arachidonic acid treatment
Outcome group
Receptor activity and mechanism · Reproductive and sexual health
Source sentences
Summary
Treating cells with 0.1 mM arachidonic acid for 15 min at 37 degrees C increased the affinity of VIP receptors and the potency of the neuropeptide (up to five times) in the formation of cyclic AMP at maturity, but not at puberty.
1 context sentence(design, population, supporting numbers)
Summary · context
prostatic epithelial cells from rats at puberty and maturity
In this study, Vasoactive intestinal peptide (VIP, aviptadil) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Vasoactive intestinal peptide (VIP, aviptadil).
Report a problemFND-0133737704
05LabNot a test of Vasoactive intestinal peptide (VIP, aviptadil) aloneIn vitro (cells)Mechanism
In rat prostatic epithelial cells, average plasma membrane fluidity remained unmodified after arachidonic acid treatment.
In plain wordsIn rat prostate cells, arachidonic acid did not change the average fluidity of the cell membrane.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
No significant changePlasma membrane fluidity after arachidonic acid
Study
ratn: not reported in source
Prostatic epithelial cells from pubertal and mature rats
Comparator
Cells without arachidonic acid treatment
Outcome group
Receptor activity and mechanism · Reproductive and sexual health
Source sentences
Summary
The average plasma membrane fluidity (as measured by fluorescence polarization of diphenylhexatriene) remained unmodified after arachidonic acid treatment of cells.
1 context sentence(design, population, supporting numbers)
Summary · context
prostatic epithelial cells from rats at puberty and maturity
In this study, Vasoactive intestinal peptide (VIP, aviptadil) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Vasoactive intestinal peptide (VIP, aviptadil).
Report a problemFND-0133737705
06LabNot a test of Vasoactive intestinal peptide (VIP, aviptadil) aloneIn vitro (cells)Mechanism
In mature rat prostatic epithelial cells, arachidonic acid did not affect cyclic AMP stimulation by isoproterenol or forskolin, so the change was specific to the VIP receptor system.
In plain wordsIn mature rat prostate cells, arachidonic acid did not alter cyclic AMP responses to two other stimulants, only the VIP response.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
No significant changeIsoproterenol- or forskolin-stimulated cyclic AMP after arachidonic acid
Study
ratn: not reported in source
Prostatic epithelial cells from pubertal and mature rats
Comparator
Cells without arachidonic acid treatment
Outcome group
Receptor activity and mechanism · Reproductive and sexual health
Source sentences
Summary
The modifications observed in mature rats were specific for the VIP receptor/effector system, since cyclic AMP stimulation by isoproterenol or forskolin was not affected by cell treatment with arachidonic acid.
1 context sentence(design, population, supporting numbers)
Summary · context
prostatic epithelial cells from rats at puberty and maturity
In this study, Vasoactive intestinal peptide (VIP, aviptadil) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Vasoactive intestinal peptide (VIP, aviptadil).
Report a problemFND-0133737706

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
12 Oct 2026, 12:58 UTC
Study results updated
Version 1
9 Oct 2026, 12:41 UTC
First added · source update from Europe PMC

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